Abstract
The Word Memory Test (WMT) is a commonly used symptom validity test (SVT) that assesses recognition verbal memory. The task has been adapted for use within a functional magnetic resonance imaging (fMRI) paradigm so the neural correlates of WMT activation patterns can be studied. In the current investigation, performance on the delayed recognition subtest of the WMT was examined in two patients who sustained severe TBI and compared to ten healthy controls. The patients underwent comprehensive neuropsychological evaluations and structural MRI. All participants completed two versions of the WMT: full-effort and simulated poor effort conditions. Despite extensive structural brain damage, the fMRI activation patterns during full-effort WMT performance were somewhat similar in the two TBI patients and likewise, somewhat similar to controls. The fMRI activation pattern in both patients demonstrated intact activation of the basic neural structures necessary to perform the WMT. Dissimilar patterns of activation were obtained during the simulated poor effort condition of WMT performance suggesting that fMRI techniques may be sensitive in demonstrating non-credible cognitive performance. The results of our study represent the first fMRI investigation of normal and simulated poor effort SVT performance in individuals with documented brain damage. The implications of fMRI techniques in SVT research and their clinical application are discussed.
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References
Allen, M. D., & Fong, A. K. (2008a). Clinical application of standardized cognitive assessment using fMRI. I. Matrix reasoning. Behavioural Neurology, 20, 127–140.
Allen, M. D., & Fong, A. K. (2008b). Clinical application of standardized cognitive assessment using fMRI. II. Verbal fluency. Behavioural Neurology, 20, 141–152.
Allen, M. D., Bigler, E. D., Larsen, J., Goodrich-Hunsaker, N. J., & Hopkins, R. O. (2007). Functional neuroimaging evidence for high cognitive effort on the Word Memory Test in the absence of external incentives. Brain Injury, 21, 1425–1428.
Bianchini, K. J., Mathias, C. W., & Greve, K. W. (2001). Symptom validity testing: a critical review. Clinical Neuropsychology, 15, 19–45.
Boone, K. B. (2008). The need for continuous and comprehensive sampling of effort/response bias during neuropsychological examinations. Clin Neuropsychol, 1-13.
Braver, T. S., & Bongiolatti, S. R. (2002). The role of frontopolar cortex in subgoal processing during working memory. Neuroimage, 15, 523–536.
Browndyke, J. N., Paskavitz, J., Sweet, L. H., Cohen, R. A., Tucker, K. A., Welsh-Bohmer, K. A., et al. (2008). Neuroanatomical correlates of malingered memory impairment: event-related fMRI of deception on a recognition memory task. Brain Injury, 22, 481–489.
Bush, S. S. (2005). Independent and court-ordered forensic neuropsychological examinations: official statement of the National Academy of Neuropsychology. Archives of Clinical Neuropsychology, 20, 997–1007.
Cabeza, R. (2008). Role of parietal regions in episodic memory retrieval: the dual attentional processes hypothesis. Neuropsychologia, 46, 1813–1827.
Christoff, K., Prabhakaran, V., Dorfman, J., Zhao, Z., Kroger, J. K., Holyoak, K. J., et al. (2001). Rostrolateral prefrontal cortex involvement in relational integration during reasoning. Neuroimage, 14, 1136–1149.
D’Esposito, M., Postle, B. R., Ballard, D., & Lease, J. (1999). Maintenance versus manipulation of information held in working memory: an event-related fMRI study. Brain and Cognition, 41, 66–86.
Dodrill, C. B. (2008). Do patients with psychogenic nonepileptic seizures produce trustworthy findings on neuropsychological tests? Epilepsia, 49(4), 691–695.
Ensalada, L. H. (2000). The importance of illness behavior in disability management. Occupational Medicine, 15, 739–754. iv.
Esposito, F., Mulert, C., & Goebel, R. (2009a). Combined distributed source and single-trial EEG-fMRI modeling: application to effortful decision making processes. Neuroimage, 47, 112–121.
Esposito, F., Mulert, C., & Goebel, R. (2009b). Combined distributed source and single-trial EEG-fMRI modeling: application to effortful decision making processes. Neuroimage.
Frazier, T. W., Youngstrom, E. A., Naugle, R. I., Haggerty, K. A., & Busch, R. M. (2007). The latent structure of cognitive symptom exaggeration on the Victoria Symptom Validity Test. Archives of Clinical Neuropsychology, 22, 197–211.
Frederick, R. I., & Bowden, S. C. (2009). Evaluating constructs represented by symptom validity tests in forensic neuropsychological assessment of traumatic brain injury. Journal of Head Trauma Rehabilitation, 24, 105–122.
Gorissen, M., Sanz, J. C., & Schmand, B. (2005). Effort and cognition in schizophrenia patients. Schizophrenia Research, 78, 199–208.
Green, P. (2003). Manual for the Word Memory Test for Windows. Edmonton: Green.
Kohl, A. D., Wylie, G. R., Genova, H. M., Hillary, F. G., & Deluca, J. (2009). The neural correlates of cognitive fatigue in traumatic brain injury using functional MRI. Brain Injury, 23, 420–432.
Lee, T. M., Liu, H. L., Tan, L. H., Chan, C. C., Mahankali, S., Feng, C. M., et al. (2002). Lie detection by functional magnetic resonance imaging. Human Brain Mapping, 15, 157–164.
Lee, T. M., Liu, H. L., Chan, C. C., Ng, Y. B., Fox, P. T., & Gao, J. H. (2005). Neural correlates of feigned memory impairment. Neuroimage, 28, 305–313.
Loring, D. W., Larrabee, G. J., Lee, G. P., & Meador, K. J. (2007). Victoria Symptom Validity Test performance in a heterogenous clinical sample. Clin Neuropsychol, 21, 522–531.
McCarter, R. J., Walton, N. H., Brooks, D. N., & Powell, G. E. (2009). Effort Testing in Contemporary UK Neuropsychological Practice. Clinical Neuropsychologist, 1-17.
Morgan, J. E., & Sweet, J. J. (2008). Neuropsychology of malingering casebook. New York: Psychology.
Richman, J., Green, P., Gervais, R., Flaro, L., Merten, T., Brockhaus, R., et al. (2006). Objective tests of symptom exaggeration in independent medical examinations. Journal of Occupational and Environmental Medicine, 48, 303–311.
Ruocco, A. C., Swirsky-Sacchetti, T., Chute, D. L., Mandel, S., Platek, S. M., & Zillmer, E. A. (2008). Distinguishing between neuropsychological malingering and exaggerated psychiatric symptoms in a neuropsychological setting. Clinical Neuropsychologist, 22, 547–564.
Sarter, M. (2004). Animal cognition: defining the issues. Neuroscience and Biobehavioral Reviews, 28, 645–650.
Sarter, M., Gehring, W. J., & Kozak, R. (2006). More attention must be paid: the neurobiology of attentional effort. Brain Res Rev, 51, 145–160.
Seghier, M. L., Lazeyras, F., Pegna, A. J., Annoni, J. M., & Khateb, A. (2008). Group analysis and the subject factor in functional magnetic resonance imaging: analysis of fifty right-handed healthy subjects in a semantic language task. Human Brain Mapping, 29, 461–477.
Wallis, J. D. (2007). Orbitofrontal cortex and its contribution to decision-making. Annual Review of Neuroscience, 30, 31–56.
Weber, B., Kugler, F., & Elger, C. E. (2007). Comparison of implicit memory encoding paradigms for the activation of mediotemporal structures. Epilepsy & Behavior, 10, 442–448.
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Wu, T.C., Allen, M.D., Goodrich-Hunsaker, N.J. et al. Functional Neuroimaging of Symptom Validity Testing in Traumatic Brain Injury. Psychol. Inj. and Law 3, 50–62 (2010). https://doi.org/10.1007/s12207-010-9067-y
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DOI: https://doi.org/10.1007/s12207-010-9067-y