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Cobalt ferrite decoration of molybdenum disulfide nanosheets; development of a nanocomposite-mediated hyperthermia method

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Abstract

The aims were to characterize MoS2/CoFe2O4 nanocomposite and investigate its thermal therapy efficiency on cancerous (MCF-7) and normal (MCF-10A) human breast cells. Magnetic nanocomposites (MNCs) characterized by scanning/transmission electron microscopy (SEM/TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR) and vibrating sample magnetometer (VSM) techniques. TEM and SEM techniques showed MoS2/CoFe2O4 MNCs had an average size of 17±4 nm with almost spherical morphology. Magnetic properties of MNC measured by VSM, which resulted in specific loss power (SLP) of 766.61 W/g at 300 K. Cytotoxicity of MoS2/CoFe2O4 nanocomposites in MCF-7 and MCF-10A cell lines remained insignificant until 48 hours, which confirms its biocompatibility. Low concentration (200 ug/mL) of MoS2/CoFe2O4 was exposed to the low-frequency alternative magnetic field (f = 150 kHz, H = 31.16 mT) in a way that delivery of thermal ablation via magnetic fluid hyperthermia (MFH) occurred exclusively in cancerous (MCF-7) cells.

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Abbreviations

K:

Kelvin temperature scale

T:

Temperature or celsius temperature scale

W:

(Watt) Effective work

f :

Frequency (Hz)

H:

Auxiliary magnetic field, electromagnetic amplitude

C:

Concentration

mT:

Mili Tesla

emu/g:

(Mass) magnetization

Oe:

Oersted, unit of the auxiliary magnetic field

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Authors and Affiliations

  1. Department of Mechanical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

    Mohammadhossein Shahsavari Alavijeh, Adel Maghsoudpour & Morteza Khayat

  2. Stem Cell Technology Research Center, Tehran, Iran

    Iman Rad & Shadie Hatamie

  3. Institute of Nano Engineering and Micro-Systems, National Tsing Hua University, Hsinchu, 30013, Taiwan

    Shadie Hatamie

Authors
  1. Mohammadhossein Shahsavari Alavijeh
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  2. Adel Maghsoudpour
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  3. Morteza Khayat
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  4. Iman Rad
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  5. Shadie Hatamie
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Corresponding author

Correspondence to Adel Maghsoudpour.

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Recommended by Editor Sehyun Shin

Adel Maghsoudpour received his M.Sc. and Ph.D. degrees in Mechanical Engineering from University of Tehran and SRBIAU, Tehran, Iran, respectively. His main research interest include hyperthermia and free vibrations.

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Alavijeh, M.S., Maghsoudpour, A., Khayat, M. et al. Cobalt ferrite decoration of molybdenum disulfide nanosheets; development of a nanocomposite-mediated hyperthermia method. J Mech Sci Technol 35, 1319–1325 (2021). https://doi.org/10.1007/s12206-020-1242-9

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  • DOI: https://doi.org/10.1007/s12206-020-1242-9

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