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Cognition and Hemodynamics

  • Elderly and Cardiovascular Disease (DE Forman and JM Gaziano, Section Editors)
  • Published:
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Abstract

The relationship between cerebral hemodynamics and cognitive performance has increasingly become recognized as a major challenge in clinical practice for older adults. Both diabetes and hypertension worsen brain perfusion and are major risk factors for cerebrovascular disease, stroke, and dementia. Cerebrovascular reserve has emerged as a potential biomarker for monitoring pressure–perfusion–cognition relationships. Endothelial dysfunction and inflammation, microvascular disease, and mascrovascular disease affect cerebral hemodynamics and play an important role in pathohysiology and severity of multiple medical conditions, presenting as cognitive decline in the old age. Therefore, the identification of cerebrovascular vascular reactivity as a new therapeutic target is needed for prevention of cognitive decline late in life.

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Acknowledgments

V. Novak was supported by grants 1R01AG028076-A2 and 1P01AG028717-01A2 from the National Institute on Aging, NIH, and by grant 1R21DK084463-01A1 from the National Institute of Diabetes and Digestive and Kidney Diseases, NIH.

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    Vera Novak

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V. Novak wrote the article, researched data to include in the manuscript, reviewed and edited the manuscript prior to submission, and revised the manuscript in response to the peer-reviewers’ comments.

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Novak, V. Cognition and Hemodynamics. Curr Cardiovasc Risk Rep 6, 380–396 (2012). https://doi.org/10.1007/s12170-012-0260-2

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