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Fluorescent oligo and poly-thiophenes and their utilization for recording biological events of diverse origin—when organic chemistry meets biology

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Journal of Chemical Biology

Abstract

The technique of using luminescent oligo-thiophenes and luminescent conjugated poly-thiophenes to monitor biological processes has gained increased interest from scientists within different research areas, ranging from organic chemistry and photo-physics to biology since its introduction. The technique is generally straightforward and requires only standard equipment, and the result is available within minutes from sample preparation. In this review, the syntheses of oligo and polythiophenes developed over the last decades are discussed. Furthermore, the utilization of these molecular agents for exploring biological events, e.g., DNA hybridization or protein misfolding events, are covered.

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References

  1. Andersson M, Ekeblad PO, Hjertberg T, Wennerström O, Ingenäs O (1991) Polythiophene with a free amino acid side chain. Polym Commun (Guildf) 32(18):546–548

    CAS  Google Scholar 

  2. Nilsson KPR, Andersson MR, Inganäs O (2002) Conformational transitions of a free amino-acid-functionalized polythiophene induced by different buffer systems. J Phys Condens Matter 14(42):10011–10020

    Article  CAS  Google Scholar 

  3. Charych DH, Nagy JO, Spevak W, Bednarski MD (1993) Direct colorimetric detection of a receptor-ligand interaction by a polymerized bilayer assembly. Science 261(5121):585–588

    Article  CAS  Google Scholar 

  4. Ewbank PC, Nuding G, Suenaga H, McCullough RD, Shinkai S (2001) Amine functionalized polythiophenes: synthesis and formation of chiral, ordered structures on DNA substrates. Tetrahedron Lett 42(2):155–157

    Article  CAS  Google Scholar 

  5. Barbarella G, Zambianchi M, Pudova O, Paladini V, Ventola A, Cipriani F, Gigli G, Cingolani R, Citro G (2001) Oligothiophene lsothiocyanates as a new class of fluorescent markers for biopolymers. J Am Chem Soc 123(47):11600–11607

    Article  CAS  Google Scholar 

  6. Nilsson KPR, Inganäs O (2003) Chip and solution detection of DNA hybridization using a luminescent zwitterionic polythiophene derivative. Nat Mater 2(6):419–U10

    Article  CAS  Google Scholar 

  7. Nilsson KPR, Rydberg J, Baltzer L, Inganäs O (2003) Self-assembly of synthetic peptides control conformation and optical properties of a zwitterionic polythiophene derivative. Proc Natl Acad Sci U S A 100(18):10170–10174

    Article  CAS  Google Scholar 

  8. Eberhard O (1894) Chem Ber 27:2919

    Article  CAS  Google Scholar 

  9. Lin JWP, Dudek LP (1980) Synthesis and properties of POLY(2,5-THIENYLENE). J Polym Sci A-1 Polym Chem 18(9):2869–2873

    CAS  Google Scholar 

  10. Takakazu Yamamoto KSAY (1980) Preparation of thermostable and electric-conducting poly(2,5-thienylene). J Polym Sci Polym Lett Ed 18(1):9–12

    Article  Google Scholar 

  11. Yoshino K, Hayashi S, Sugimoto R-I (1984) Preparation and properties of conducting heterocyclic polymer films by chemical method. Jpn J Appl Phys Lett 23(12):899–900

    Article  CAS  Google Scholar 

  12. Baek MG, Stevens RC, Charych DH (2000) Design and synthesis of novel glycopolythiophene assemblies for colorimetric detection of influenza virus and E. coli. Bioconjug Chem 11(6):777–788

    Article  CAS  Google Scholar 

  13. Ho HA, Boissinot M, Bergeron MG, Corbeil G, Dore K, Boudreau D, Leclerc M (2002) Colorimetric and fluorometric detection of nucleic acids using cationic polythiophene derivatives. Angew Chem Int Edit 41(9):1548–1551

    Article  CAS  Google Scholar 

  14. Nilsson KPR, Inganäs O (2004) Optical emission of a conjugated polyelectrolyte: calcium-induced conformational changes in calmodulin and calmodulin–calcineurin interactions. Macromolecules 37(24):9109–9113

    Article  CAS  Google Scholar 

  15. Nilsson KPR, Rydberg J, Baltzer L, Inganäs O (2004) Twisting macromolecular chains: self-assembly of a chiral supermolecule from nonchiral polythiophene polyanions and random-coil synthetic peptides. Proc Natl Acad Sci U S A 101(31):11197–11202

    Article  CAS  Google Scholar 

  16. Herland A, Nilsson KPR, Olsson JDM, Hammarström P, Konradsson P, Inganäs O (2005) Synthesis of a regioregular zwitterionic conjugated oligoelectrolyte, usable as an optical probe for detection of amyloid fibril formation at acidic pH. J Am Chem Soc 127(7):2317–2323

    Article  CAS  Google Scholar 

  17. Åslund A, Herland A, Hammarström P, Nilsson KP, Jonsson BH, Inganäs O, Konradsson P (2007) Studies of luminescent conjugated polythiophene derivatives: enhanced spectral discrimination of protein conformational States. Bioconjug Chem 18(6):1860–1868

    Article  CAS  Google Scholar 

  18. Nilsson KPR, Åslund A, Berg I, Nyström S, Konradsson P, Herland A, Inganäs O, Stabo-Eeg F, Lindgren M, Westermark GT, Lannfelt L, Nilsson LN, Hammarström P (2007) Imaging distinct conformational states of amyloid-beta fibrils in Alzheimer's disease using novel luminescent probes. ACS Chem Biol 2(8):553–560

    Article  CAS  Google Scholar 

  19. Chayer M, Faïd K, Leclerc M (1997) Highly conducting water-soluble polythiophene derivatives. Chem Mater 9(12):2902–2905

    Article  CAS  Google Scholar 

  20. Karlsson RH, Herland A, Mahiar H, Wigenius JA, Åslund A, Inganäs O, Konradsson P (2009) Iron-catalyzed polymerization of alkoxysulfonate-functionalized 3, 4-ethylenedioxythiophene gives water-soluble poly(3,4-ethylenedioxythiophene) of high conductivity. Chem Mater 21(9):1815–1821. doi:10.1021/cm801512r

    Article  CAS  Google Scholar 

  21. McCarley TD, Noble, DuBois CJ, McCarley RL (2001) MALDI-MS evaluation of poly(3-hexylthiophene) synthesized by chemical oxidation with FeCl3. Macromolecules 34(23):7999–8004

    Article  CAS  Google Scholar 

  22. Nilsson KPR, Olsson JDM, Konradsson P, Inganäs O (2004) Enantiomeric substituents determine the chirality of luminescent conjugated polythiophenes. Macromolecules 37(17):6316–6321

    Article  CAS  Google Scholar 

  23. Pomerantz M, Tseng JJ, Zhu H, Sproull SJ, Reynolds JR, Uitz R, Arnott HJ, Haider MI (1991) Processable polymers and copolymers of 3-alkylthiophenes and their blends. Synth Met 41(3):825–830

    Article  CAS  Google Scholar 

  24. Yue S, Berry GC, McCullough RD (1996) Intermolecular association and supramolecular organization in dilute solution. 1. Regioregular poly(3-dodecylthiophene). Macromolecules 29(3):933–939

    Article  CAS  Google Scholar 

  25. Jayakannan M, van Dongen JLJ, Janssen RAJ (2001) Mechanistic aspects of the Suzuki polycondensation of thiophenebisboronic derivatives and diiodobenzenes analyzed by MALDI-TOF mass spectrometry. Macromolecules 34(16):5386–5393

    Article  CAS  Google Scholar 

  26. McCullough RD, Lowe RD (1992) Enhanced electrical-conductivity in regioselectively synthesized poly(3-alkylthiophenes). J Chem Soc Chem Commun 1:70–72

    Article  Google Scholar 

  27. Maior RMS, Hinkelmann K, Eckert H, Wudl F (1990) Synthesis and characterization of 2 regiochemically defined Poly(Dialkylbithiophenes)—a comparative-study. Macromolecules 23(5):1268–1279

    Article  CAS  Google Scholar 

  28. McCullough RD (1998) The chemistry of conducting polythiophenes. Adv Mater 10(2):93–116

    Article  CAS  Google Scholar 

  29. Osaka I, McCullough RD (2008) Advances in molecular design and synthesis of regioregular polythiophenes. Acc Chem Res 41(9):1202–1214

    Article  CAS  Google Scholar 

  30. Stille J (1986) The Palladium-catalyzed cross-coupling reactions of organotin reagents with organic electrophiles [New Synthetic Methods (58)]. Angew Chem Int Ed Engl 25(6):508–524

    Article  Google Scholar 

  31. Miyaura N, Yamada K, Suzuki A (1979) A new stereospecific cross-coupling by the palladium-catalyzed reaction of 1-alkenylboranes with 1-alkenyl or 1-alkynyl halides. Tetrahedron Lett 20(36):3437–3440

    Article  Google Scholar 

  32. Miyaura N, Suzuki A (1979) Stereoselective synthesis of arylated (E)-alkenes by the reaction of alk-1-enylboranes with aryl halides in the presence of palladium catalyst. J Chem Soc Chem Commun 19:866–867

    Article  Google Scholar 

  33. Farina V, Krishnan B (1991) Large rate accelerations in the stille reaction with Tri-2-Furylphosphine and Triphenylarsine as palladium ligands - mechanistic and synthetic Implications. J Am Chem Soc 113(25):9585–9595

    Article  CAS  Google Scholar 

  34. Herrmann WA, Elison M, Fischer J, Köcher C, Artus GRJ (1995) Metal complexes of N-heterocyclic carbenes—a new structural principle for catalysts in homogeneous catalysis. Angew Chem Int Ed Engl 34(21):2371–2374

    Article  CAS  Google Scholar 

  35. Kantchev EAB, O'Brien CJ, Organ MG (2007) Palladium complexes of N-heterocyclic carbenes as catalysts for cross-coupling reactions - A synthetic chemist's perspective. Angew Chem Int Ed Engl 46(16):2768–2813

    Article  CAS  Google Scholar 

  36. Martina S, Enkelman V, Schlueter AD, Wegner G (1991) Polypyrrole: towards the development of a chemical synthesis. Synth Met 41(1–2):403–406

    Article  CAS  Google Scholar 

  37. Melucci M, Barbarella G, Sotgiu G (2002) Solvent-free, microwave-assisted synthesis of thiophene oligomers via Suzuki coupling. J Org Chem 67(25):8877–8884

    Article  CAS  Google Scholar 

  38. Kirschbaum T, Azumi R, Mena-Osteritz E, Bauerle P (1999) Synthesis and characterization of structurally defined head-to-tail coupled oligo(3-alkylthiophenes). New J Chem 23(2):241–250

    Article  CAS  Google Scholar 

  39. Briehn CA, Kirschbaum T, Bauerle P (2000) Polymer-supported synthesis of regioregular head-to-tail-coupled Oligo(3-arylthiophene)s utilizing a traceless silyl linker. J Org Chem 65(2):352–359

    Article  CAS  Google Scholar 

  40. Kirschbaum T, Briehn CA, Bauerle P (2000) Efficient solid-phase synthesis of regioregular head-to-tail-coupled oligo(3-alkylthiophene)s up to a dodecamer. J Chem Soc Perkin Trans 1 8:1211–1216

    Article  Google Scholar 

  41. Cremer J, Mena-Osteritz E, Pschierer NG, Mullen K, Bauerle P (2005) Dye-functionalized head-to-tail coupled oligo(3-hexylthiophenes)-perylene-oligothiophene dyads for photovoltaic applications. Org Biomol Chem 3(6):985–995

    Article  CAS  Google Scholar 

  42. Villemin D, Caillot F (2001) Microwave mediated palladium-catalysed reactions on potassium fluoride/alumina without use of solvent. Tetrahedron Lett 42(4):639–642

    Article  CAS  Google Scholar 

  43. Organ MG, Avola S, Dubovyk I, Hadei N, Kantchev EAB, O'Brien CJ, Valente C (2006) A user-friendly, all-purpose Pd-NHC (NHC=N-heterocyclic carbene) precatalyst for the Negishi reaction: a step towards a universal cross-coupling catalyst. Chemistry 12(18):4749–4755

    Article  CAS  Google Scholar 

  44. Rosivatz E (2008) Imaging the boundaries—innovative tools for microscopy of living cells and real-time imaging. J Chem Biol 1(1):3–15

    Article  Google Scholar 

  45. Leclerc M (1999) Optical and electrochemical transducers based on functionalized conjugated polymers. Adv Mater 11(18):1491–1498

    Article  CAS  Google Scholar 

  46. Zhou Q, Swager TM (1995) Methodology for enhancing the sensitivity of fluorescent chemosensors - energy migration in conjugated polymers. J Am Chem Soc 117(26):7017–7018

    Article  CAS  Google Scholar 

  47. Zhou Q, Swager TM (1995) Fluorescent chemosensors based on energy migration in conjugated polymers: The molecular wire approach to increased sensitivity. J Am Chem Soc 117(50):12593–12602

    Article  CAS  Google Scholar 

  48. Wang J, Wang DL, Miller EK, Moses D, Bazan GC, Heeger AJ (2000) Photoluminescence of water-soluble conjugated polymers: Origin of enhanced quenching by charge transfer. Macromolecules 33(14):5153–5158

    Article  CAS  Google Scholar 

  49. Harrison BS, Ramey MB, Reynolds JR, Schanze KS (2000) Amplified fluorescence quenching in a poly(p-phenylene)-based cationic polyelectrolyte. J Am Chem Soc 122(35):8561–8562

    Article  CAS  Google Scholar 

  50. Jones RM, Bergstedt TS, McBranch DW, Whitten DG (2001) Tuning of superquenching in layered and mixed fluorescent polyelectrolytes. J Am Chem Soc 123(27):6726–6727

    Article  CAS  Google Scholar 

  51. Ho HA, Najari A, Leclerc M (2008) Optical Detection of DNA and Proteins with Cationic Polythiophenes. Acc. Chem. Res 41(2):168–178

    Article  CAS  Google Scholar 

  52. Ho HA, DorÈ K, Boissinot M, Bergeron MG, Tanguay RM, Boudreau D, Leclerc M (2005) Direct molecular detection of nucleic acids by fluorescence signal amplification. J Am Chem Soc 127(36):12673–12676

    Article  CAS  Google Scholar 

  53. Doré K, Leclerc M, Boudreau D (2006) Investigation of a fluorescence signal amplification mechanism used for the direct molecular detection of nucleic acids. J Fluoresc 16(2):259–265

    Article  CAS  Google Scholar 

  54. Najari A, Ho HA, Gravel JF, Nobert P, Boudreau D, Leclerc M (2006) Reagentless ultrasensitive specific DNA array detection based on responsive polymeric biochips. Anal Chem 78(22):7896–7899

    Article  CAS  Google Scholar 

  55. Ho HA, Leclerc M (2004) Optical sensors based on hybrid aptamer/conjugated polymer complexes. J Am Chem Soc 126(5):1384–1387

    Article  CAS  Google Scholar 

  56. Serpell LC, Sunde M, Blake CC (1997) The molecular basis of amyloidosis. Cell Mol Life Sci 53(11–12):871–887

    Article  CAS  Google Scholar 

  57. Harper JD, Lieber CM, Lansbury PT Jr (1997) Atomic force microscopic imaging of seeded fibril formation and fibril branching by the Alzheimer's disease amyloid-beta protein. Chem Biol 4(12):951–959

    Article  CAS  Google Scholar 

  58. Bennhold H (1922) Eine specifische Amyloidfärbung mit Kongorot. Műnchener Med. Wochenschrift 44:1537–1537

    Google Scholar 

  59. Divry P (1927) Etude histochimique des plaques seniles. J. Belge Neurol Psychiatry 27:643–657

    Google Scholar 

  60. Westermark GT, Johnson KH, Westermark P (1999) Staining methods for identification of amyloid in tissue. Methods Enzymol 309:3–25

    Article  CAS  Google Scholar 

  61. Khurana R, Uversky VN, Nielsen L, Fink AL (2001) Is Congo red an amyloid-specific dye? J Biol Chem 276(25):22715–22721

    Article  CAS  Google Scholar 

  62. Naiki H, Higuchi K, Hosokawa M, Takeda T (1989) Fluorometric determination of amyloid fibrils in vitro using the fluorescent dye, thioflavin T1. Anal Biochem 177(2):244–249

    Article  CAS  Google Scholar 

  63. LeVine H 3rd (1993) Thioflavine T interaction with synthetic Alzheimer's disease beta-amyloid peptides: detection of amyloid aggregation in solution. Protein Sci 2(3):404–410

    CAS  Google Scholar 

  64. Voropai ES, Samtsov MP, Kaplevskii KN, Maskevich AA, Stepuro VI, Povarova OI, Kuznetsova IM, Turoverov KK, Fink AL, Uverskii VN (2003) Spectral properties of thioflavin T and its complexes with amyloid fibrils. J Appl Spectrosc 70(6):868–874

    Article  CAS  Google Scholar 

  65. Crystal AS, Giasson BI, Crowe A, Kung MP, Zhuang ZP, Trojanowski JQ, Lee VM (2003) A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. J Neurochem 86(6):1359–1368

    Article  CAS  Google Scholar 

  66. LeVine H 3rd (2005) Mechanism of A beta(1–40) fibril-induced fluorescence of (trans, trans)-1-bromo-2, 5-bis(4-hydroxystyryl)benzene (K114). Biochemistry 44(48):15937–15943

    Article  CAS  Google Scholar 

  67. Styren SD, Hamilton RL, Styren GC, Klunk WE (2000) X-34, a fluorescent derivative of Congo red: a novel histochemical stain for Alzheimer's disease pathology. J Histochem Cytochem 48(9):1223–1232

    CAS  Google Scholar 

  68. Nesterov EE, Skoch J, Hyman BT, Klunk WE, Bacskai BJ, Swager TM (2005) In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers. Angew Chem Int Edit 44(34):5452–5456

    Article  CAS  Google Scholar 

  69. Fraser H, Dickinson AG (1968) The sequential development of the brain lesion of scrapie in three strains of mice. J Comp Pathol 78(3):301–311

    Article  CAS  Google Scholar 

  70. Fraser H, Dickinson AG (1973) Scrapie in mice. Agent-strain differences in the distribution and intensity of grey matter vacuolation. J Comp Pathol 83(1):29–40

    Article  CAS  Google Scholar 

  71. Bruce ME, McBride PA, Farquhar CF (1989) Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie. Neurosci Lett 102(1):1–6

    Article  CAS  Google Scholar 

  72. Bessen RA, Marsh RF (1992) Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent. J Virol 66(4):2096–2101

    CAS  Google Scholar 

  73. Hill AF, Joiner S, Beck JA, Campbell TA, Dickinson A, Poulter M, Wadsworth JD, Collinge J (2006) Distinct glycoform ratios of protease resistant prion protein associated with PRNP point mutations. Brain 129(Pt 3):676–685

    Article  Google Scholar 

  74. Chiti F, Dobson CM (2006) Protein misfolding, functional amyloid, and human disease. Ann Rev Biochem 75:333–366

    Article  CAS  Google Scholar 

  75. Kayed R, Head E, Thompson JL, McIntire TM, Milton SC, Cotman CW, Glabe CG (2003) Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300(5618):486–489

    Article  CAS  Google Scholar 

  76. Kayed R, Head E, Sarsoza F, Saing T, Cotman CW, Necula M, Margol L, Wu J, Breydo L, Thompson JL, Rasool S, Gurlo T, Butler P, Glabe CG (2007) Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers. Mol Neurodegener 2:18

    Article  CAS  Google Scholar 

  77. Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL (2007) Monoclonal antibodies that target pathological assemblies of Abeta. J Neurochem 100(1):23–35

    Article  CAS  Google Scholar 

  78. Wang XP, Zhang JH, Wang YJ, Feng Y, Zhang X, Sun XX, Li JL, Du XT, Lambert MP, Yang SG, Zhao M, Klein WL, Liu RT (2009) Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers. FEBS Lett 583(3):579–584

    Article  CAS  Google Scholar 

  79. Nilsson KPR, Herland A, Hammarström P, Inganäs O (2005) Conjugated polyelectrolytes: Conformation-sensitive optical probes for detection of amyloid fibril formation. Biochemistry 44(10):3718–3724

    Article  CAS  Google Scholar 

  80. Nilsson KPR, Hammarström P, Ahlgren F, Herland A, Schnell EA, Lindgren M, Westermark GT, Inganäs O (2006) Conjugated polyelectrolytes - Conformation-sensitive optical probes for staining and characterization of amyloid deposits. Chembiochem 7(7):1096–1104

    Article  CAS  Google Scholar 

  81. Jin LW, Claborn KA, Kurimoto M, Geday MA, Maezawa I, Sohraby F, Estrada M, Kaminksy W, Kahr B (2003) Imaging linear birefringence and dichroism in cerebral amyloid pathologies. Proc Natl Acad Sci U S A 100(26):15294–15298

    Article  CAS  Google Scholar 

  82. Groenning M, Norrman M, Flink JM, van de Weert M, Bukrinsky JT, Schluckebier G, Frokjaer S (2007) Binding mode of Thioflavin T in insulin amyloid fibrils. J Struct Biol 159(3):483–497

    Article  CAS  Google Scholar 

  83. Herland A, Bjork P, Hania PR, Scheblykin IG, Inganäs O (2007) Alignment of a conjugated polymer onto amyloid-like protein fibrils. Small 3(2):318–325

    Article  CAS  Google Scholar 

  84. Sigurdson CJ, Nilsson KP, Hornemann S, Manco G, Polymenidou M, Schwarz P, Leclerc M, Hammarström P, Wuthrich K, Aguzzi A (2007) Prion strain discrimination using luminescent conjugated polymers. Nat Methods 4(12):1023–1030

    Article  CAS  Google Scholar 

  85. Stabo-Eeg F, Lindgren M, Nilsson KPR, Inganäs O, Hammarström P (2007) Quantum efficiency and two-photon absorption cross-section of conjugated polyelectrolytes used for protein conformation measurements with applications on amyloid structures. Chem Phys 336(2–3):121–126

    Article  CAS  Google Scholar 

  86. Sigurdson CJ, Nilsson KP, Hornemann S, Heikenwalder M, Manco G, Schwarz P, Ott D, Rulicke T, Liberski PP, Julius C, Falsig J, Stitz L, Wuthrich K, Aguzzi A (2009) De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis. Proc Natl Acad Sci U S A 106(1):304–309

    Article  CAS  Google Scholar 

  87. Nilsson KPR, Olsson JDM, Stabo-Eeg F, Lindgren M, Konradsson P, Inganäs O (2005) Chiral recognition of a synthetic peptide using enantiomeric conjugated polyelectrolytes and optical spectroscopy. Macromolecules 38(16):6813–6821

    Article  CAS  Google Scholar 

  88. Bolmont T, Haiss F, Eicke D, Radde R, Mathis CA, Klunk WE, Kohsaka S, Jucker M, Calhoun ME (2008) Dynamics of the microglial/amyloid interaction indicate a role in plaque maintenance. J Neurosci 28(16):4283–4292

    Article  CAS  Google Scholar 

  89. Kuchibhotla KV, Lattarulo CR, Hyman BT, Bacskai BJ (2009) Synchronous hyperactivity and intercellular calcium waves in astrocytes in alzheimer mice. Science 323(5918):1211–1215

    Article  CAS  Google Scholar 

  90. Nilsson KPR, Hammarström P (2008) Luminescent conjugated polymers: illuminating the dark matters of biology and pathology. Adv Mater 20(13):2639–2645

    Article  CAS  Google Scholar 

  91. Hamedi M, Herland A, Karlsson RH, Inganäs O (2008) Electrochemical devices made from conducting nanowire networks self-assembled from amyloid fibrils and alkoxysulfonate PEDOT. Nano Lett 8(6):1736–1740

    Article  CAS  Google Scholar 

  92. Li F, Martens AA, Åslund A, Konradsson P, de Wolf FA, Stuart MAC, Sudholter EJR, Marcelis ATM, Leermakers FAM (2009) Formation of nanotapes by co-assembly of triblock peptide copolymers and polythiophenes in aqueous solution. Soft Matter 5:1668–1673

    Article  CAS  Google Scholar 

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Acknowledgements

Our work is supported by the Swedish Foundation for Strategic Research (as a grant to the research consortium OBOE, K.P.R.N, P.K., and A.Å and as a repatriation grant, Ingvar Carlsson award, K.P.R.N.) and the Knut and Alice Wallenberg foundation (K.P.R.N.). A generous gift from Astrid and Georg Olsson is also gratefully acknowledged and the Swedish research foundation (P.K). A.Å is enrolled in the doctoral program Forum Scientum.

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  1. Department of Physics, Chemistry and Biology, Linköping University, Linköping, Sweden

    Andreas Åslund, K. Peter R. Nilsson & Peter Konradsson

  2. Linköpings Universitet, IFM-Kemi, Valla Hus B, 581 83, Linköping, Sweden

    Andreas Åslund

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Correspondence to Andreas Åslund.

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Åslund, A., Nilsson, K.P.R. & Konradsson, P. Fluorescent oligo and poly-thiophenes and their utilization for recording biological events of diverse origin—when organic chemistry meets biology. J Chem Biol 2, 161–175 (2009). https://doi.org/10.1007/s12154-009-0024-8

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