Abstract
Objectives
Advances in radiopharmaceuticals and clinical understanding have escalated the use of intraoperative gamma probes in surgery. However, most probes on the market are non-imaging gamma probes that suffer from the lack of ancillary information of the surveyed tissue area. We have developed a novel, hand-held digital Imaging Beta Probe™ (IBP™) to be used in surgery in conjunction with beta-emitting radiopharmaceuticals such as 18FDG, 131I and 32P for real-time imaging of a surveyed area with higher spatial resolution and sensitivity and greater convenience than existing instruments.
Methods
We describe the design and validation of a hand-held beta probe intended to be used as a visual mapping device to locate and confirm excision of 18FDG-avid primary tumors and metastases in an animal model.
Results
We have demonstrated a device which can generate beta images from 18FDG avid lesions in an animal model.
Conclusions
It is feasible to image beta irradiation in animal models of cancer given 18FDG. This technology may be applied to clinical mapping of tumors and/or their metastases in the operating room. Visual image depiction of malignancy may aid the surgeon in localization and excision of lesions of interest.
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References
O’Dwyer PJ, Mojzisik M, Hinkle G, Rousseau M, Olsen J, Tuttle SE, et al. Intraoperative probe directed immunodetection using a monoclonal antibody. Arch Surg. 1986;121(12):1391–4.
Sardi A, Workman M, Mojzisik C, Hinkle G, Nieroda C, Martin EW. Intra-abdominal recurrence of colorectal cancer detected by radioimmunoguided surgery (RIGS). Arch Surg. 1989;124(1):55–9.
Cohen AM, Martin EW, Lavery I, Daly J, Sardi A, Aitken D, et al. Radioimmunoguided surgery using iodine 125 B72.3 in patients with colorectal cancer. Arch Surg. 1991;126(3):349–52.
Scott GC, Meier DA, Dickinson CZ. Cervical Lymph Node Metastasis of Thyroid Papillary Carcinoma Imaged with Fluorine-18 FDG, Technetium-99 m-Pertechnetate and Iodine-131-Sodium Iodide. J Nucl Med. 1995;36:1843–5.
Adams S, Baum RP, Hertel A, Wenisch HJC, Staib-Sebler E, Herrmann G, et al. Intraoperative gamma probe detection of neuroendocrine tumors. J Nucl Med. 1998;39(7):1155–60.
Thacker SC, Stack BC Jr, Lowe V, Gaysinskiy V, Cool S, Nagarkar VV, et al. A novel imaging ß-probe for radioguided surgery. IEEE NSS/MIC. 2008;3875–8.
Nagarkar VV, Shestakova I, Gaysinskiy V, Tipnis SV, Singh B, Barber W, et al. CCD-based detector for SPECT. Nucl Sci. 2006;53(1):54–8.
Daghighian F, Mazziotta JC, Hoffman EJ, Shenderov P, Eshaghian B, Siegel S, et al. Intraoperative beta probe: a device for detecting tissue labeled with positron or electron emitting isotopes during surgery. Med Phys. 1994;21(1):153–7.
Raylmann RR. A solid-state intraoperative beta probe system. Nucl Sci. 2001;47(4):352–60.
Essner R, Daghighian F, Giuliano AE. Advances in FDG PET probes in surgical oncology. Cancer J. 2002;8(2):100–8.
Wendler T, Traub J, Ziegler S, Navab N. Validation of navigated beta-probe imaging with PET/CT-generated activity surfaces, New approach in radio-guided resection for FDG-positive tumors. J Nucl Med. 2007;48(Supplement 2):46.
Gulec SA, Daghighian F, Essner R. PET-probe: evaluation of technical performance and clinical utility of a handheld high-energy gamma probe in oncologic surgery. Ann Surg Oncol. 2006. doi 10.1245/ASO.2006.05.047. Available from: http://www.annalssurgicaloncology.org.
Strong VE, Galanis CJ, Riedl CC, Longo VA, Daghighian F, Humm JL, et al. Portable PET probes are a novel tool for intraoperative localization of tumor deposits. Ann Surg Innov Res. 2009;3(2). doi:10.1186/1750-1164-3-2. Available online at: http://www.asir-journal.com/content/3/1/2.
Fujita H, Tsai DY, Itoh T, Doi K, Morishita J, Ueda K, et al. A simple method for determining the MTF in digital radiography. Medical Imaging. 1992;11(1):34–9.
Shestakova I, Stack BC Jr, Gaysinskiy V, Entine G, Nagarkar VV. Feasibility of an EMCCD-based beta imaging probe for radioguided surgery. In: Nuclear Science Symposium Conference Record IEEE. 2005, vol 3, p 4.
Samei E, Flynn MJ, Reimann DA. A method for measuring the presampled MTF of digital radiographic systems using an edge test device. Med Phys. 1998;25(1):102–13.
Samei E, Flynn MJ. An experimental comparison of detector performance for direct and indirect digital radiographic systems. Med Phys. 2003;30(4):608–22.
Dargie M, SCHOTT North America, Inc. (Southbridge, MA, USA), personal communication, 2010; http://web.princeton.edu/sites/ehs/radmanual/radman_app_b.htm#p32.
Stack BC Jr, Ye J, Bartel T, Shafirstein G, Chen C, Siegel ER, et al. Orthotopic VX rabbit tongue cancer: a model for FDG-PET imaging and radiosurgery in the head and neck. Head Neck. 2012 (epub Sept 19).
Internet and other references
IntraMedical Imaging LLC (Los Angeles, CA, USA). http://www.gammaprobe.com/products/betaprobe.
IntraMedical Imaging LLC (Los Angeles, CA, USA). http://www.intra-medical.com/beta.html.
Acknowledgments
This work was supported in part by the NIH (2 R44 CA096030-03A1). The authors would also like to thank Terrie Alpe from UAMS.
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Singh, B., Stack, B.C., Thacker, S. et al. A hand-held beta imaging probe for FDG. Ann Nucl Med 27, 203–208 (2013). https://doi.org/10.1007/s12149-012-0672-6
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DOI: https://doi.org/10.1007/s12149-012-0672-6