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A new border for circadian rhythm gene NFIL3 in diverse fields of cancer

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Abstract

The circadian rhythm disorder and abnormal expression of rhythm genes are related to many diseases, especially cancer. Rhythm gene NFIL3 is involved in energy metabolism and immune cell differentiation, and its aberrant expression is associated with metabolic diseases and inflammation. Previously, numerous studies have shown that aberrant NFIL3 expression is associated with tumorigenesis, progression, and chemotherapy resistance. For instance, NFIL3 performs as a nuclear transcription factor, impacts cell proliferation, represses apoptosis, and promotes cancer cell invasion and metastasis by regulating the transcription of target genes. In addition, NFIL3 expressed in cancer cells influences the type and proportion of infiltrated immune cells in the tumor microenvironment. Increased expression of NFIL3 induces the chemotherapy and immunotherapy resistance in cancer. In this review, we summarized the pathological functions of NFIL3 in tumorigenesis, cancer development, and treatment. The rhythm gene NFIL3 can be used as a promising target in cancer therapy in the future.

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Data availability

The data used during the current review are available from the corresponding author on reasonable request.

Abbreviations

AMPK:

AMP-activated protein kinase

ATP:

Adenosine triphosphate

BMP:

Bone morphogenetic protein

bZIP:

Basic leucine zipper

DBP:

Albumin D-site-binding protein

DCs:

Dendritic cells

EMT:

Epithelial–mesenchymal transition

ER:

Endoplasmic reticulum

FGF21:

Fibroblast growth factor 21

FOXO:

Forkhead box

Foxp3:

Forkhead box protein p3

HDAC2:

Histone deacetylase-2

HKDC1:

Hexokinase domain containing 1

IGF-2:

Insulin-like growth factor 2

M1:

Type I macrophages

M2:

Type II macrophages

NAFLD:

Non-alcoholic fatty liver disease

NFIL3:

Nuclear factor, interleukin-3 regulated

NFKBIA:

NF-κB inhibitor alpha

NF-κB:

Nuclear factor κB

NK:

Natural Killer

PEPCK:

Phosphoenolpyruvate carboxykinase

PER:

Period

PHEX:

Phosphate regulating endopeptidase homolog X-linked

PRNP:

Prion protein

PrPc:

Cellular prion protein

RASSF8:

Ras-association domain family member 8

RORγt:

Orphan nuclear receptor

SOSTDC1:

Sclerostin domain containing 1

SREBP-1c:

Sterol regulatory element-binding protein-1c

STAT3:

Signal transducer and activator of transcription 3

SUV39H1:

Suppressor of variegation 3-9 homolog 1

Th1:

T-helper1

Th17:

T-helper17

Th2:

T-helper2

TNBC:

Triple-negative breast cancer

TRAIL:

Tumor necrosis factor-related apoptosis-inducing ligand

Tregs:

Regulatory cells

TTFL:

Transcriptional and translational feedback loop

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Funding

The work of Weiwei Yang was funded by the Heilongjiang Province Postdoctoral Scientific Research Developmental Fund (Grant No. LBH-Q20046) and the Natural Science Foundation of Heilongjiang Province of China (Grant No. LH2022H008) and the work of Minghui Zhang was supported by the Natural Science Foundation of Inner Mongolia (Grant No. 2020MS08084).

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  1. Lixuan Zeng, DongXin Chen, Yang Xue, and Minghui Zhang have contributed equally to this work. Professor Weiwei Yang is the main corresponding author.

Authors and Affiliations

  1. Department of Pathology, Harbin Medical University, No. 157 Baojian Road, Harbin, 150086, Heilongjiang, People’s Republic of China

    Lixuan Zeng, DongXin Chen, Yang Xue, Yiqi Wu & Weiwei Yang

  2. Department of Oncology, Chifeng City Hospital, Chifeng, 024000, China

    Minghui Zhang

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YWW and WYQ offered main direction and significant guidance of this manuscript. ZLX, CDX, XY, and ZMH drafted the manuscript and illustrated the figures for the manuscript. All authors approved the final manuscript.

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Zeng, L., Chen, D., Xue, Y. et al. A new border for circadian rhythm gene NFIL3 in diverse fields of cancer. Clin Transl Oncol 25, 1940–1948 (2023). https://doi.org/10.1007/s12094-023-03098-5

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