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An integrated signal transduction network of macrophage migration inhibitory factor

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Journal of Cell Communication and Signaling Aims and scope

Abstract

Macrophage migration inhibitory factor (MIF) is a glycosylated multi-functional protein that acts as an enzyme as well as a cytokine. MIF mediates its actions through a cell surface class II major histocompatibility chaperone, CD74 and co-receptors such as CD44, CXCR2, CXCR4 or CXCR7. MIF has been implicated in the pathogenesis of several acute and chronic inflammatory diseases. Although MIF is a molecule of biomedical importance, a public resource of MIF signaling pathway is currently lacking. In view of this, we carried out detailed data mining and documentation of the signaling events pertaining to MIF from published literature and developed an integrated reaction map of MIF signaling. This resulted in the cataloguing of 68 molecules belonging to MIF signaling pathway, which includes 24 protein-protein interactions, 44 post-translational modifications, 11 protein translocation events and 8 activation/inhibition events. In addition, 65 gene regulation events at the mRNA levels induced by MIF signaling have also been catalogued. This signaling pathway has been integrated into NetPath (http://www.netpath.org), a freely available human signaling pathway resource developed previously by our group. The MIF pathway data is freely available online in various community standard data exchange formats. We expect that data on signaling events and a detailed signaling map of MIF will provide the scientific community with an improved platform to facilitate further molecular as well as biomedical investigations on MIF.

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Abbreviations

MIF:

Macrophage migration inhibitory factor

PPI:

Protein-protein interaction

PTM:

Post-translational modification

HPRD:

Human Protein Reference Database

SBML:

Systems Biology Markup Language

PSI-MI:

Proteomics Standards Initiative for Molecular Interaction

BioPAX:

Biological Pathway Exchange

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Acknowledgments

We thank the Department of Biotechnology (DBT), Government of India for research support to the Institute of Bioinformatics. IOB is supported by DBT Program Support on Neuroproteomics and infrastructure for proteomic data analysis (BT/01/COE/08/05). We thank the “Infosys Foundation” for the research support to the Institute of Bioinformatics. HG is a Wellcome Trust/DBT India Alliance Early Career Fellow. JA is a recipient of Senior Research Fellowship from the Council for Scientific and Industrial Research (CSIR), India.

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Authors and Affiliations

  1. Institute of Bioinformatics, International Technology Park, Whitefield, Bangalore, 560066, India

    Tejaswini Subbannayya, Jayshree Advani, Harsha Gowda, Aditi Chatterjee & T. S. Keshava Prasad

  2. Amrita School of Biotechnology, Amrita University, Kollam, 690525, India

    Tejaswini Subbannayya, Bipin Nair & T. S. Keshava Prasad

  3. Armed Forces Medical College, Pune, 411040, India

    Prathyaksha Variar

  4. Manipal University, Madhav Nagar, Manipal, 576104, India

    Jayshree Advani

  5. Command Hospital (Air Force), Bangalore, 560007, India

    Subramanian Shankar

  6. YU-IOB Center for Systems Biology and Molecular Medicine, Yenepoya University, Mangalore, 575018, India

    Harsha Gowda, Aditi Chatterjee & T. S. Keshava Prasad

  7. Laboratory of Anatomy and Cell Biology, Faculty of Medicine and Pharmacy, University of Mons, B-7000, Mons, Belgium

    Sven Saussez

  8. NIMHANS-IOB Proteomics and Bioinformatics Laboratory, Neurobiology Research Centre, National Institute of Mental Health and Neurosciences, Bangalore, 560029, India

    T. S. Keshava Prasad

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  1. Tejaswini Subbannayya
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  2. Prathyaksha Variar
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  3. Jayshree Advani
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  9. T. S. Keshava Prasad
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Correspondence to Aditi Chatterjee or T. S. Keshava Prasad.

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Subbannayya, T., Variar, P., Advani, J. et al. An integrated signal transduction network of macrophage migration inhibitory factor. J. Cell Commun. Signal. 10, 165–170 (2016). https://doi.org/10.1007/s12079-016-0326-x

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