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Sensational MicroRNAs: Neurosensory Roles of the MicroRNA-183 Family

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Abstract

MicroRNAs (miRNAs, miRs) are short noncoding RNAs that act to repress expression of proteins from target mRNA transcripts. miRNAs influence many cellular processes including stemness, proliferation, differentiation, maintenance, and survival, and miRNA mutations or misexpression are associated with a variety of disease states. The miR-183 family gene cluster including miR-183, miR-96, and miR-182 is highly conserved among vertebrate and invertebrate organisms, and the miRNAs are coordinately expressed with marked specificity in sensory neurons and sensory epithelial cells. The crucial functions of these miRNAs in normal cellular processes are not yet fully understood, but expectedly dependent upon the transcriptomes of specific cell types at different developmental stages or in various maintenance circumstances. This article provides an overview of evidence supporting roles for miR-183 family members in normal biology of the nervous system, including mechanoreception for auditory and vestibular function, electroreception, chemoreception, photoreception, circadian rhythms, sensory ganglia and pain, and memory formation.

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Abbreviations

1KO:

miR-182 knockout

2KO:

miR-183/96 knockout

3KO:

miR-183/96/182 knockout

AC:

Anterior crista

ADCY6:

Adenylate cyclase VI

Atoh1:

Atonal bHLH transcription factor 1

BDNF:

Brain-derived neurotrophic factor

BKCa :

Potassium large conductance calcium-activated channel

CKO:

Conditional knockout

CLIC5:

Chloride intracellular channel 5

Ddx3x:

DEAD-box helicase 3 X-linked

DGCR8:

DiGeorge syndrome critical region 8

EPHB1:

Ephrin type-b receptor 1

FOXO3a:

Forkhead box O3

GFI1:

Growth factor independent 1

HC:

Horizontal crista

HEI-OC1:

The House Ear Institute Organ of Corti 1 mouse auditory cell line

HET:

Heterozygous

HIBI:

Hypoxic-ischemia brain injury

iMOP:

Immortalized multipotent otic progenitor cell line

Kb:

Kilobase

KO:

Knockout

KV1.6:

Potassium voltage-gated channel subfamily A member 6

LTMRs:

Low-threshold mechanoreceptors

mESC:

Mouse embryonic stem cells

miRNAs, miRs:

microRNAs

miR-183, miR-96, miR-182:

miR-183 family

MITF:

microphthalmia-associated transcription factor

NaV1.3:

Sodium voltage-gated channel alpha subunit 3

NIHL:

Noise-induced hearing loss

NRF1:

Nuclear respiratory factor 1

OC:

Organ of Corti

OLF1:

Olfactory neuron-specific transcription factor 1

PC:

Posterior crista

pre-miRNAs:

Precursor microRNAs

pri-miRNAs:

Primary microRNAs

RT-PCR:

Reverse transcription polymerase chain reaction

S:

Saccular macula

SCN:

Suprachiasmatic nucleus

Shox2:

Short stature homeobox 2

Taok1:

TAO kinase 1

TRBP:

Trans-activation response RNA-binding protein

SG:

Spiral ganglion

U:

Utricular macula

Ube2h:

Ubiquitin-conjugating enzyme E2 H

UTR:

Untranslated region

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  1. Department of Biomedical Sciences, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, 68178, USA

    Samantha A. Banks & Garrett A. Soukup

  2. Department of Pharmacology, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE, 68178, USA

    Marsha L. Pierce

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Banks, S.A., Pierce, M.L. & Soukup, G.A. Sensational MicroRNAs: Neurosensory Roles of the MicroRNA-183 Family. Mol Neurobiol 57, 358–371 (2020). https://doi.org/10.1007/s12035-019-01717-3

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