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Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis

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Abstract

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) are important for the maintenance of brain homeostasis. During sepsis, peripheral production of proinflammatory cytokines and reactive oxygen species are responsible for structural alterations in those brain barriers. Thus, an increasing permeability of these barriers can lead to the activation of glial cells such as microglia and the production of cytotoxic mediators which in turn act on the brain barriers, damaging them further. Thereby, in this review, we try to highlight how the brain barrier’s permeability is not only a cause but a consequence of brain injury in sepsis.

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Acknowledgements

The Translational Psychiatry Program (USA) is funded by the Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth). Laboratory of Neurosciences (Brazil) is one of the centers of the National Institute for Molecular Medicine (INCT-MM) and one of the members of the Center of Excellence in Applied Neurosciences of Santa Catarina (NENASC). Its research is supported by grants from CNPq (JQ, FP, TB, FD-P), FAPESC (JQ); Instituto Cérebro e Mente (JQ), UNESC (JQ, TB, FD-P) and UNISUL (FP). JQ and FP are 1A and TB and FP are level 2 CNPq Research Fellow.

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Authors and Affiliations

  1. Laboratório de Neurobiologia de Processos Inflamatórios e Metabólicos, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Sul de Santa Catarina, Tubarão, SC, Brazil

    Lucineia Gainski Danielski, Amanda Della Giustina & Fabrícia Petronilho

  2. Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA

    Marwa Badawy, Tatiana Barichello & João Quevedo

  3. Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA

    Tatiana Barichello & João Quevedo

  4. Neuroscience Graduate Program, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, Houston, TX, USA

    Tatiana Barichello & João Quevedo

  5. Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil

    Tatiana Barichello

  6. Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil

    João Quevedo

  7. Laboratory of Experimental Pathophysiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil

    Felipe Dal-Pizzol

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  1. Lucineia Gainski Danielski
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  2. Amanda Della Giustina
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Correspondence to Fabrícia Petronilho.

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Danielski, L.G., Giustina, A.D., Badawy, M. et al. Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis. Mol Neurobiol 55, 1045–1053 (2018). https://doi.org/10.1007/s12035-016-0356-7

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  • DOI: https://doi.org/10.1007/s12035-016-0356-7

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