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Analyzing 54,936 Samples Supports the Association Between CD2AP rs9349407 Polymorphism and Alzheimer’s Disease Susceptibility

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Abstract

The CD2-associated protein (CD2AP) rs9349407 polymorphism was first identified to be significantly associated with Alzheimer’s disease (AD) in European ancestry by genome-wide association studies (GWAS). However, the following studies reported no association in Chinese, Japanese, African-American, Canadian, and European populations. We think that these negative results may have been caused by either relatively small sample sizes compared with those used for the previous GWAS in European ancestry or the genetic heterogeneity of the rs9349407 polymorphism in different populations. Here, we reevaluated this association using the relatively large-scale samples from 15 previous studies (N = 54,936; 23,777 cases and 31,159 controls) by searching the PubMed, AlzGene, and Google Scholar databases. Using an additive genetic model, we did not identify a significant heterogeneity among the 15 studies. Using meta-analysis, we observed a significant association between the rs9349407 polymorphism and AD with P = 8.78E-07, odds ratio (OR) = 1.08, 95 % confidence interval (CI) 1.05–1.12. To our knowledge, this is the first meta-analysis to investigate the association between rs9349407 polymorphism and AD in East Asian, American, Canadian, and European populations. Our analysis further supports previous findings that the CD2AP rs9349407 polymorphism contributes to AD susceptibility. We believe that our findings will be very useful for future genetic studies on AD.

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Acknowledgments

This work was supported by funding from the National Nature Science Foundation of China (grant numbers 81300945, 31301938, 31200934, 31171219, 81271213, 81070878, 81271214, and 81261120404), the Natural Science Foundation of Guangdong Province, China (No. S2012010008222), and the Science and Technology Innovation Fund of Guangdong Medical College (No. STIF 201101).

Conflict of Interest

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Neurology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China

    Hongyuan Chen & Chunjiang Yu

  2. Department of Gerontology, The Second Hospital of Harbin, Harbin, China

    Guihua Wu

  3. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

    Yongshuai Jiang

  4. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China

    Rennan Feng

  5. College of Life Science, Northwest A&F University, Yangling, Shaanxi, China

    Mingzhi Liao

  6. Department of Statistics, Rice University, Houston, TX, USA

    Liangcai Zhang

  7. Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China

    Guoda Ma & Keshen Li

  8. Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA, USA

    Zugen Chen

  9. Key laboratory of aging-related Cardio-cerebral diseases of Guangdong Province, Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China

    Bin Zhao & Keshen Li

  10. Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Xiqi Dao 32, Tianjin Airport Economic Area, Tianjin, 300308, China

    Guiyou Liu

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  1. Hongyuan Chen
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Correspondence to Bin Zhao, Keshen Li, Chunjiang Yu or Guiyou Liu.

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Hongyuan Chen and Guihua Wu contributed equally to this work.

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Chen, H., Wu, G., Jiang, Y. et al. Analyzing 54,936 Samples Supports the Association Between CD2AP rs9349407 Polymorphism and Alzheimer’s Disease Susceptibility. Mol Neurobiol 52, 1–7 (2015). https://doi.org/10.1007/s12035-014-8834-2

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