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PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer’s Disease in an Asian Population

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Abstract

PICALM gene rs3851179 polymorphism was reported to an Alzheimer’s disease (AD) susceptibility locus in a Caucasian population. However, recent studies reported consistent and inconsistent results in an Asian population. Four studies indicated no association between rs3851179 and AD in a Chinese population and one study reported weak association in a Japanese population. We consider that the failure to replicate the significant association between rs3851179 and AD may be caused by at least two reasons. The first reason may be the genetic heterogeneity in AD among different populations, and the second may be the relatively small sample size compared with large-scale GWAS in Caucasian ancestry. In order to confirm this view, in this research, we first evaluated the genetic heterogeneity of rs3851179 polymorphism in Caucasian and Asian populations. We then investigated rs3851179 polymorphism in an Asian population by a pooled analysis method and a meta-analysis method. We did not observe significant genetic heterogeneity of rs3851179 in the Caucasian and Asian populations. Our results indicate that rs3851179 polymorphism is significantly associated with AD in the Asian population by both pooled analysis and meta-analysis methods. We believe that our findings will be very useful for future genetic studies in AD.

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Acknowledgments

This research is supported by grants from the National Nature Science Foundation of China (Grant number 31171219, 81271213, and 31200934) and US-China Biomedical Collaborative Research Program (NSFC Grant number 81261120404) to Keshen Li, and One Hundred Person Project of the Chinese Academy of Sciences (KSCX2-YW-BR-3)

Conflict of interest

The authors reported no biomedical financial interests or potential conflicts of interest.

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Authors and Affiliations

  1. Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China

    Guiyou Liu, Guoda Ma & Keshen Li

  2. Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Beijing, China

    Guiyou Liu

  3. Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, 150001, China

    Shuyan Zhang

  4. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China

    Liangcai Zhang, Yongshuai Jiang & Mingzhi Liao

  5. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China

    Rennan Feng

  6. Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA, USA

    Zugen Chen

  7. Key Laboratory of Aging-Related Cardio-Cerebral Diseases of Guangdong Province, Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China

    Zhiyou Cai, Bin Zhao & Keshen Li

Authors
  1. Guiyou Liu
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  2. Shuyan Zhang
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  3. Zhiyou Cai
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  4. Guoda Ma
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  5. Liangcai Zhang
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  6. Yongshuai Jiang
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  7. Rennan Feng
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  8. Mingzhi Liao
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  9. Zugen Chen
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  10. Bin Zhao
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  11. Keshen Li
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Corresponding authors

Correspondence to Bin Zhao or Keshen Li.

Additional information

Guiyou Liu and Shuyan Zhang contributed equally to this work.

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Liu, G., Zhang, S., Cai, Z. et al. PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer’s Disease in an Asian Population. Neuromol Med 15, 384–388 (2013). https://doi.org/10.1007/s12017-013-8225-2

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  • DOI: https://doi.org/10.1007/s12017-013-8225-2

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