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Bergmann Glia Function in Granule Cell Migration During Cerebellum Development

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Abstract

Granule cell migration influences the laminar structure of the cerebellum and thereby affects cerebellum function. Bergmann glia are derived from radial glial cells and aid in granule cell radial migration by providing a scaffold for migration and by mediating interactions between Bergmann glia and granule cells. In this review, we summarize Bergmann glia characteristics and the mechanisms underlying the effect of Bergmann glia on the radial migration of granule neurons in the cerebellum. Furthermore, we will focus our discussion on the important factors involved in glia-mediated radial migration so that we may elucidate the possible mechanistic pathways used by Bergmann glia to influence granule cell migration during cerebellum development.

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Acknowledgments

This study was supported by the National Nature Science Foundation of China (Nos. 31070927 and 31071299) and the Scientific Research Foundation for the Returned Overseas Chongqing Scholars (cstc2011jjzt0137).

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  1. Southwest Eye Hospital, Southwest Hospital, Third Military Medical University, Chongqing, 400038, People’s Republic of China

    Haiwei Xu & Baoke Hou

  2. Department of Histology and Embryology, Third Military Medical University, Chongqing, 400038, People’s Republic of China

    Yang Yang, Xiaotong Tang, Meina Zhao, Fucheng Liang, Pei Xu, Yan Xing, Xiaohang Bao & Xiaotang Fan

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  1. Haiwei Xu
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Xu, H., Yang, Y., Tang, X. et al. Bergmann Glia Function in Granule Cell Migration During Cerebellum Development. Mol Neurobiol 47, 833–844 (2013). https://doi.org/10.1007/s12035-013-8405-y

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