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An Appraisal on Prominent Industrial and Biotechnological Applications of Bacterial Lipases

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Abstract

Microbial lipases expedite the hydrolysis and synthesis of long-chain acyl esters. They are highly significant commercial biocatalysts to biotechnologists and organic chemists. The market size of lipase is anticipated to reach $590 million by 2023. This is all owing to their versatility in properties, including stability in organic solvents, interfacial activation in micro-aqueous environments, high substrate specificity, and activity in even non-aqueous milieu. Lipases are omnipresent and synthesized by various living organisms, including animals, plants, and microorganisms. Microbial lipases are the preferred choice for industrial applications as they entail low production costs, higher yield independent of seasonal changes, easier purification practices, and are capable of being genetically modified. Microbial lipases are employed in several common industries, namely various food manufactories (dairy, bakery, flavor, and aroma enhancement, etc.), leather tanneries, paper and pulp, textiles, detergents, cosmetics, pharmaceuticals, biodiesel synthesis, bioremediation and waste treatment, and many more. In recent decades, circumspection toward eco-friendly and sustainable energy has led scientists to develop industrial mechanisms with lesser waste/effluent generation, minimal overall energy usage, and biocatalysts that can be synthesized using renewable, low-cost, and unconventional raw materials. However, there are still issues regarding the commercial use of lipases which make industrialists wary and sometimes even switch back to chemical catalysis. Industrially relevant lipase properties must be further optimized, analyzed, and explored to ensure their continuous successful utilization. This review comprehensively describes the general background, structural characteristics, classifications, thermostability, and various roles of bacterial lipases in important industries.

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All data generated or analysed during this study are included in this published article [and its supplementary information file].

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Acknowledgements

This work is carried out with the help of prestigious material from the institute’s libraries. And supported by Grant No. 43/ORIC/19 from the office of research innovation & commercialization (ORIC).

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  1. Institute of Industrial Biotechnology, Government College University, Lahore, 54000, Pakistan

    Fatima Akram, Azka Shahzad Mir & Ikram ul Haq

  2. Pakistan Academy of Sciences, Islamabad, Pakistan

    Ikram ul Haq

  3. Kinnaird College for Women, 93 Jail Road, Lahore, 54000, Pakistan

    Ayesha Roohi

  4. University of the Punjab, Quaid-i-Azam Campus, Lahore, 54000, Pakistan

    Ayesha Roohi

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Akram, F., Mir, A.S., Haq, I.u. et al. An Appraisal on Prominent Industrial and Biotechnological Applications of Bacterial Lipases. Mol Biotechnol 65, 521–543 (2023). https://doi.org/10.1007/s12033-022-00592-z

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