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The functions of N6-methyladenosine (m6A) RNA modifications in colorectal cancer

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Abstract

Colorectal cancers (CRC), which includes colon cancer (CC) and rectal cancer (RC), are some of the most common malignant tumors that are prone to distant metastasis. Its high incidence rate and high mortality rate have attracted much attention. In recent years, epigenetics has attracted increasing attention and has been the focus of many research studies. N6-methyladenosine(m6A) RNA modifications can modify eukaryotic mRNA to impact metabolism. The changes in the m6A regulatory genes are related to the occurrence and development of CRC and play an important role in the pathogenesis of CRC. The effect of m6A RNA modification is regulated by its related regulatory factors ("writer", "eraser", "reader"). In this review, we comprehensively analyzed the effect of m6A methylation on CRC and the relationship between the expression of related regulatory factors and the development and occurrence of CRC. Then, we summarized the roles of m6A and its regulatory factors in CRC and its potential clinical value, which provides a basis for further research on the mechanism of m6A methylation in CRC.

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  1. Haiyan Qiao, Linfeng Liu and Jun Chen contributed equally to this work.

Authors and Affiliations

  1. Comparative Medicine Department of Researching and Teaching, Dalian Medical University, Dalian City, 116044, Liaoning Province, China

    Haiyan Qiao, Linfeng Liu, Bingbing Shang & Liang Wang

  2. Laboratory Animal Center, Dalian Medical University, Dalian, Dalian City, 116044, Liaoning Province, China

    Jun Chen

  3. Emergency Department, The Second Hospital of Dalian Medical University, Dalian, Dalian City, 116027, Liaoning Province, China

    Bingbing Shang

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Qiao, H., Liu, L., Chen, J. et al. The functions of N6-methyladenosine (m6A) RNA modifications in colorectal cancer. Med Oncol 39, 235 (2022). https://doi.org/10.1007/s12032-022-01827-4

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