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Interleukin-17A and interleukin-17F gene polymorphisms and hepatitis B virus-related hepatocellular carcinoma risk in a Chinese population

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Abstract

Interleukin (IL)-17A and IL-17F are inflammatory cytokines, which play a critical function in inflammation. Genetic variations in the IL-17A and IL-17F genes may be associated with a risk of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC), which is a typical inflammation-related cancer. However, their relationship with HBV-related HCC has not been thoroughly investigated. We conducted a case–control study including 155 patients with HBV-related HCC and 171 healthy controls to assess the association between IL-17A rs4711998, IL-17A rs2275913, and IL-17F rs763780 polymorphisms and risk of HCC. Genotypes were determined by polymerase chain reaction–restriction fragment length polymorphism and DNA sequencing. There were no significant differences in the genotype and allele frequencies of IL-17A rs4711998, IL-17A rs2275913, and IL-17F rs763780 polymorphisms between the HBV-related HCC patients and healthy controls. However, our results revealed a statistically significant association between the ACA haplotype and increased HCC risk [odds ratio (OR) 1.820, 95 % confidence interval (CI) 1.181–2.624, P = 0.013]. In contrast, the GCG haplotype was associated with a significantly decreased risk of HBV-related HCC (OR 0.454, 95 % CI 0.112–0.898, P = 0.035). Our results suggest that IL-17A rs4711998, IL-17A rs2275913, and IL-17F rs763780 polymorphisms do not contribute to HBV-related HCC susceptibility independently. However, the ACA and GCG haplotypes in the IL-17 gene might be a risk factor and a protective marker, respectively, for HBV-related HCC in a Chinese population.

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Acknowledgments

We thank Scribendi.com for its linguistic assistance during the preparation of this manuscript. This research was supported by National Natural Science Foundation of China (Nos. 81260302 and 81460431).

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Authors and Affiliations

  1. Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China

    Xue-E Xi, Yanqiong Liu, Yu Lu, Xue Qin & Shan Li

  2. Department of Clinical Laboratory, The Second People’s Hospital of Nanning, Nanning, Guangxi, China

    Liying Huang

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  1. Xue-E Xi
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Correspondence to Xue Qin or Shan Li.

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Xue-E Xi and Yanqiong Liu have contributed equally to this work.

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Xi, XE., Liu, Y., Lu, Y. et al. Interleukin-17A and interleukin-17F gene polymorphisms and hepatitis B virus-related hepatocellular carcinoma risk in a Chinese population. Med Oncol 32, 355 (2015). https://doi.org/10.1007/s12032-014-0355-3

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