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Extrapituitary growth hormone

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Abstract

Pituitary somatotrophs secrete growth hormone (GH) into the bloodstream, to act as a hormone at receptor sites in most, if not all, tissues. These endocrine actions of circulating GH are abolished after pituitary ablation or hypophysectomy, indicating its pituitary source. GH gene expression is, however, not confined to the pituitary gland, as it occurs in neural, immune, reproductive, alimentary, and respiratory tissues and in the integumentary, muscular, skeletal, and cardiovascular systems, in which GH may act locally rather than as an endocrine. These actions are likely to be involved in the proliferation and differentiation of cells and tissues prior to the ontogeny of the pituitary gland. They are also likely to complement the endocrine actions of GH and are likely to maintain them after pituitary senescence and the somatopause. Autocrine or paracrine actions of GH are, however, sometimes mediated through different signaling mechanisms to those mediating its endocrine actions and these may promote oncogenesis. Extrapituitary GH may thus be of physiological and pathophysiological significance.

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References

  1. S. Harvey, K.L. Hull, Growth hormone: a paracrine growth factor? Endocrine 7, 267–279 (1997)

    Article  CAS  PubMed  Google Scholar 

  2. J.R. Castro, J.A. Costoya, R. Gallego, A. Prieto, V.M. Arce, R. Senaris, Expression of growth hormone receptor in the human brain. Neurosci. Lett. 281, 147–150 (2000)

    Article  CAS  PubMed  Google Scholar 

  3. H. Yoshizato, T. Fujikawa, H. Soya, M. Tanaka, K. Nakashima, The growth hormone (GH) gene is expressed in the lateral hypothalamus: enhancement by GH-releasing hormone and repression by restraints stress. Endocrinology 139, 2545–2551 (1998)

    Article  CAS  PubMed  Google Scholar 

  4. H. Yoshizato, T. Fujikawa, M. Shibata, M. Tanaka, K. Nakashima, Stimulation of growth hormone gene expression in the pituitary and brain by Panax ginseng C. A. MEYER. Endocr. J. 46, S85–S88 (1999)

    Article  CAS  PubMed  Google Scholar 

  5. C.P. Donahue, K.S. Kosik, T.J. Shors, Growth hormone is produced within the hippocampus where it responds to age, sex, and stress. Proc. Natl Acad. Sci. 103, 6031–6036 (2006)

    Article  CAS  PubMed  Google Scholar 

  6. C.P. Donahue, R.V. Jensen, T. Ochiishi, I. Eisenstein, M. Zhao, T. Shors, K.S. Kosik, Transcriptional profiling reveals regulated genes in the hippocampus during memory formation. Hippocampus 12, 821–833 (2002)

    Article  CAS  PubMed  Google Scholar 

  7. L.Y. Sun, M.S. Evans, J. Shieh, J. Panici, A. Bartke, Increased neurogenesis in dentate gyrus of long-lived Ames dwarf mice. Endocrinology 146, 1138–1144 (2005)

    Article  CAS  PubMed  Google Scholar 

  8. L.Y. Sun, K. Al-Regaiety, M.M. Maternak, J. Wang, A. Bartke, Local expression of GH and IGF-1 in the hippocampus of GH-deficient long-lived mice. Neurobiol. Aging 26, 929–937 (2005)

    Article  CAS  PubMed  Google Scholar 

  9. B.Y. Yang, M. Green, T.T. Chen, Early embryonic expression of the growth hormone family protein genes in the developing rainbow trout, Oncorhynchus mykiss. Mol. Reprod. Dev. 53, 127–134 (1999)

    Article  CAS  PubMed  Google Scholar 

  10. A. Scheepens, C.E. Williams, B.H. Breier, J. Guan, P.D. Gluckman, A role for the somatotropic axis in neural development, injury and disease. J. Pediatr. Endocrinol. Metab. 13, 1483–1491 (2000)

    PubMed  Google Scholar 

  11. A.M. Turnley, C.H. Faux, R.L. Rietz, J.R. Coonan, P.F. Bartlett, Suppressor of cytokine signaling 2 regulates neuronal differentiation by inhibiting growth hormone signaling. Nat. Neurosci. 5, 1155–1162 (2002)

    Article  CAS  PubMed  Google Scholar 

  12. R. Ramesh, W.J. Kuenzel, J.D. Buntin, J.A. Proudman, Identification of growth hormone- and prolactin-containing neurons within the avian brain. Cell Tissue Res. 299, 371–383 (2000)

    Article  CAS  PubMed  Google Scholar 

  13. S. Harvey, C.D. Johnson, E.J. Sanders, Growth hormone in neural tissues of the chick embryo. J. Endocrinol. 169, 487–498 (2001)

    Article  CAS  PubMed  Google Scholar 

  14. A.E. Murphy, S. Harvey, Extrapituitary beta TSH and GH in early chick embryos. Mol. Cell. Endocrinol. 185, 161–171 (2001)

    Article  CAS  PubMed  Google Scholar 

  15. S. Harvey, C.D. Johnson, P. Sharma, E.J. Sanders, K.L. Hull, Growth hormone: a paracrine growth factor in embryonic development? Comp. Biochem. Physiol. C: Pharmacol. Toxicol. Endocrinol. 119, 305–315 (1998)

    Article  CAS  Google Scholar 

  16. S. Harvey, K.L. Hull, Neural growth hormone: an update. J. Mol. Neurosci. 20, 1–14 (2003)

    Article  CAS  PubMed  Google Scholar 

  17. A.E. Murphy, H. Peek, M.-L. Baudet, S. Harvey, Extrapituitary GH in the chicken: underestimation of immunohistochemical staining by Carnoy’s fixture. J. Endocrinol. 177, 223–234 (2003)

    Article  CAS  PubMed  Google Scholar 

  18. E.J. Sanders, S. Harvey, Growth hormone as an early embryonic growth and differentiation factor. Dev. Dyn. 209, 1–9 (2004)

    CAS  Google Scholar 

  19. E.J. Sanders, S. Harvey, Peptide hormones as developmental growth and differentiation factors. Dev. Dyn. 237, 1537–1552 (2008)

    Article  CAS  PubMed  Google Scholar 

  20. S. Harvey, C.D. Johnson, E.J. Sanders, Extra-pituitary growth hormone in peripheral tissues of early chick embryos. J. Endocrinol. 166, 489–502 (2000)

    Article  CAS  PubMed  Google Scholar 

  21. M. Coculescu, Blood–brain barrier for human growth hormone and insulin-like growth factor-I. J. Pediatr. Endocrinol. Metab. 12, 113–124 (1999)

    CAS  PubMed  Google Scholar 

  22. W. Pan, Y. Yu, C.M. Cain, F. Nyberg, P.O. Couraud, A.J. Kastin, Permeation of growth hormone across the blood–brain barrier. Endocrinology 146, 4898–4904 (2005)

    Article  CAS  PubMed  Google Scholar 

  23. Z. Poljakovic, N. Zurak, V. Brinar, M. Korsic, S. Basic, S. Hajnsek, Growth hormone and insulin growth factor-I levels in plasma and cerebrospinal fluid of patients with multiple sclerosis. Clin. Neurol. Neurosurg. 108, 255–258 (2006)

    Article  PubMed  Google Scholar 

  24. E. Bilic, E. Bilic, I. Rudan, V. Kusec, N. Zurak, D. Delimar, M. Zagar, Comparison of growth hormone, IGF-1 and insulin in cerebrospinal fluid and serum between patients with motor neuron disease and healthy controls. Eur. J. Neurol. 13, 1340–1345 (2007)

    Article  Google Scholar 

  25. H.J. Schneider, U. Pagotto, G.K. Stalla, Central effects of the somatotropic system. Eur. J. Endocrinol. 149, 377–392 (2003)

    Article  CAS  PubMed  Google Scholar 

  26. A. Scheepens, T.A. Moderscheim, P.D. Gluckman, The role of growth hormone in neural development. Horm. Res. 64, 66–72 (2005)

    Article  CAS  PubMed  Google Scholar 

  27. N.D. Aberg, K. Gustafson Brywe, J. Isgaard, Aspects of growth hormone and insulin-like growth factor-I related to neuroprotection, regeneration, and functional plasticity in the adult brain. Sci. World J. 6, 53–80 (2006)

    Google Scholar 

  28. J. Isgaard, N.D. Aberg, M. Nilsson, Protective and regenerative effects of the GH/IGF-I axis on the brain. Min. Endocrinol. 32, 103–113 (2007)

    CAS  Google Scholar 

  29. A. Scheepens, E. Sirimanne, E. Beiharz, B.H. Breier, M.J. Waters, P.D. Gluckman, C.E. Williams, Alterations in the neural growth hormone axis following hypoxic–ischemic brain injury. Brain Res. Mol. Brain Res. 68, 88–100 (1999)

    Article  CAS  PubMed  Google Scholar 

  30. A. Scheepens, E. Sirimanne, B.H. Breier, R.G. Clark, P.D. Gluckman, C.E. Williams, Growth hormone as a neuronal rescue factor during recovery from CNS injury. Neuroscience 104, 677–687 (2001)

    Article  CAS  PubMed  Google Scholar 

  31. L. Krulich, A.P. Dhariwal, S.M. McCann, Stimulatory and inhibitory effects of purified hypothalamic extracts on growth hormone release from rat pituitary in vitro. Endocrinology 83, 783–790 (1968)

    Article  CAS  PubMed  Google Scholar 

  32. S. Harvey, I. Lavelin, M. Pines, Growth hormone (GH) action in the brain: neural expression of a GH-response gene. J. Mol. Neurosci. 18, 89–95 (2003)

    Article  Google Scholar 

  33. S. Harvey, I. Lavelin, M. Pines, Growth hormone (GH) action in early embryogenesis: expression of a GH-response gene is sites of GH production and action. Anat. Embryol. 204, 503–510 (2001)

    Article  CAS  PubMed  Google Scholar 

  34. M.-L. Baudet, D. Rattray, S. Harvey, Growth hormone and its receptor in projection neurons of the chick visual system: retinofugal and tectobulbar tracts. Neuroscience 148, 151–163 (2007)

    Article  CAS  PubMed  Google Scholar 

  35. M.-L. Baudet, E.J. Sanders, S. Harvey, Retinal growth hormone in the chick embryo. Endocrinology 144, 5459–5468 (2003)

    Article  CAS  PubMed  Google Scholar 

  36. S. Harvey, B.T. Martin, M.-L. Baudet, P. Davis, Y. Sauve, E.J. Sanders, Growth hormone in the visual system: comparative endocrinology. Gen. Comp. Endocrinol. 153, 124–131 (2007)

    Article  CAS  PubMed  Google Scholar 

  37. E.J. Sanders, M.A. Walter, E. Parker, C. Aramburo, S. Harvey, Opticin binds retinal growth hormone in the embryonic vitreous. Invest. Ophthalmol. Vis. Sci. 44, 5404–5409 (2003)

    Article  PubMed  Google Scholar 

  38. S. Harvey, M. Kakebeeke, E.J. Sanders, Growth hormone localization in the neural retina and retinal pigmented epithelium of embryonic chicks. J. Mol. Neurosci. 22, 139–145 (2004)

    Article  PubMed  Google Scholar 

  39. S. Harvey, M. Kakebeeke, A.E. Murphy, E.J. Sanders, Growth hormone in the nervous system: autocrine or paracrine roles in retinal function? Can. J. Physiol. Pharmacol. 81, 371–384 (2003)

    Article  CAS  PubMed  Google Scholar 

  40. S. Takeuchi, M. Haneda, K. Teshigawara, S. Takahashi, Identification of a novel GH isoform: a possible link between GH and melanocortin systems in the developing chicken eye. Endocrinology 142, 5158–5166 (2001)

    Article  CAS  PubMed  Google Scholar 

  41. M.-L. Baudet, S. Harvey, Small chicken growth hormone (scGH) variant in the neural retina. J. Mol. Neurosci. 31, 261–271 (2007)

    CAS  PubMed  Google Scholar 

  42. M.-L. Baudet, B. Martin, Z. Hassanali, E. Parker, E.J. Sanders, S. Harvey, Expression, translation, and localization of a novel, small growth hormone variant. Endocrinology 148, 103–115 (2007)

    Article  CAS  PubMed  Google Scholar 

  43. M.-L. Baudet, D. Rattray, B.T. Martin, S. Harvey, Growth hormone promotes axon growth in the developing nervous system. Endocrinology 150, 2758–2766 (2009)

    Article  CAS  PubMed  Google Scholar 

  44. S. Harvey, M.-L. Baudet, E.J. Sanders, Growth hormone and developmental ocular function: clinical and basic studies. Pediatr. Endocrinol. Rev. 5, 510–515 (2007)

    PubMed  Google Scholar 

  45. S. Harvey, M.-L. Baudet, E.J. Sanders, Growth hormone-induced neuroprotection in the neural retina during chick embryogenesis. Ann. N. Y. Acad. Sci. 1163, 414–416 (2009)

    Article  CAS  PubMed  Google Scholar 

  46. E.J. Sanders, E. Parker, C. Aramburo, S. Harvey, Retinal growth hormone is an anti-apoptotic factor in embryonic retinal ganglion cell differentiation. Exp. Eye Res. 81, 551–560 (2005)

    Article  CAS  PubMed  Google Scholar 

  47. E.J. Sanders, E. Parker, S. Harvey, Retinal ganglion cell survival in development: mechanisms of retinal growth hormone action. Exp. Eye Res. 83, 1205–1214 (2006)

    Article  CAS  PubMed  Google Scholar 

  48. E.J. Sanders, E. Parker, S. Harvey, Growth hormone-mediated survival of embryonic retinal ganglion cells: signaling mechanisms. Gen. Comp. Endocrinol. 156, 613–621 (2008)

    Article  CAS  PubMed  Google Scholar 

  49. E.J. Sanders, M.-L. Baudet, E. Parker, S. Harvey, Signaling mechanisms mediating local GH action in the neural retina of the chick embryo. Gen. Comp. Endocrinol. 163, 63–69 (2009)

    Article  CAS  PubMed  Google Scholar 

  50. S. Harvey, M.-L. Baudet, E.J. Sanders, Growth hormone and cell survival in the neural retina: caspase dependence in independence. Neuroreport 17, 1715–1718 (2006)

    Article  CAS  PubMed  Google Scholar 

  51. S. Harvey, M.-L. Baudet, E.J. Sanders, Retinal growth hormone in perinatal and adult rats. J. Mol. Neurosci. 28, 257–264 (2006)

    Article  CAS  PubMed  Google Scholar 

  52. E.J. Sanders, W.Y. Lin, E. Parker, S. Harvey, Growth hormone expression and neuroprotective activity in a quail neural retina cell line. Gen. Comp. Endocrinol. 165, 111−119 (2010)

  53. H.D. Modanlou, Z. Gharraee, J. Hasan, J. Waltzman, S. Nageotte, K.D. Beharry, Ontogeny of VEGF, IGF-I, and GH in neonatal rat serum, vitreous fluid, and retina from birth to weaning. Invest. Ophthalmol. Vis. Sci. 47, 738–744 (2006)

    Article  PubMed  Google Scholar 

  54. K.D. Beharry, H.D. Modanlou, J. Hasan, Z. Gharraee, P. Abad-Santos, J.H. Sills, A. Jan, S. Nageotte, J.V. Aranda, Comparative effects of early postnatal ibuprofen and indomethacin on VEGF, IGF-I, and GH during rat ocular development. Invest. Ophthalmol. Vis. Sci. 47, 3036–3043 (2006)

    Article  PubMed  Google Scholar 

  55. M.-L. Baudet, Z. Hassanali, G. Sawicki, E.O. List, J.J. Kopchick, S. Harvey, Growth hormone action in the developing neural retina: a proteomic analysis. Proteomics 8, 389–401 (2008)

    Article  CAS  PubMed  Google Scholar 

  56. R. Kiagiadaki, K. Thermos, Effect of intravitreal administration of somatostatin and sst2 analogs on AMPA-induced neurotoxicity in rat retina. Invest. Ophthalmol. Vis. Sci. 49, 3080–3089 (2008)

    Article  PubMed  Google Scholar 

  57. B.T. Martin, E.O. List, J.J. Kopchick, Y. Sauve, S. Harvey, Growth hormone overexpression is associated with selective inner retina dysfunction. Growth Horm. IGF Res. (2010), submitted

  58. J.L. Wilkinson-Berka, S. Lofthouse, K. Jaworski, S. Ninkovic, G. Tachas, C.J. Wraight, An antisense oligonucleotide targeting the growth hormone receptor inhibits neovascularization in a mouse model of retinopathy. Mol. Vis. 13, 1529–1538 (2007)

    CAS  PubMed  Google Scholar 

  59. S. Harvey, E. Parker, I. MacDonald, E.J. Sanders, Growth hormone is present in the human retina and vitreous fluid. Neurosci. Lett. 455, 199–202 (2009)

    Article  CAS  PubMed  Google Scholar 

  60. E.J. Sanders, E. Parker, S. Harvey, Endogenous growth hormone in human retinal ganglion cells correlates with cell survival. Mol. Vis. 15, 920–926 (2009)

    CAS  PubMed  Google Scholar 

  61. M. Ziaei, M. Tennant, E.J. Sanders, S. Harvey, Vitreous growth hormone and visual dysfunction. Neurosci. Lett. 460, 87–91 (2009)

    Article  CAS  PubMed  Google Scholar 

  62. D.A. Weigent, J.E. Blalock, R.D. LeBoeuf, An antisense oligodeoxynucleotide to growth hormone messenger ribonucleic acid inhibits lymphocyte proliferation. Endocrinology 128, 2053–2057 (1991)

    Article  CAS  PubMed  Google Scholar 

  63. P. Sabharwal, S. Varma, Growth hormone synthesized and secreted by human thymocytes acts via insulin-like growth factor I as an autocrine and paracrine growth factor. J. Clin. Endocrinol. Metab. 81, 2663–2669 (1996)

    Article  CAS  PubMed  Google Scholar 

  64. J.B. Baxter, J.E. Blalock, D.A. Weigent, Characterization of immunoreactive insulin-like growth factor-I from leukocytes and its regulation by growth hormone. Endocrinology 129, 1727–1734 (1991)

    Article  CAS  PubMed  Google Scholar 

  65. S. Recher, M. Raccurt, A. Lambert, P.E. Lobie, H.C. Mertani, G. Morel, Prenatal and adult growth hormone gene expression in rat lymphoid organs. J. Histochem. Cytochem. 49, 347–354 (2001)

    CAS  PubMed  Google Scholar 

  66. I.S. Lantinga van Leeuwen, E. Teske, E. van Garderen, J.A. Mol, Growth hormone gene expression in normal lymph nodes and lymphomas of the dog. Anticancer Res. 20, 2371–2376 (2000)

    CAS  PubMed  Google Scholar 

  67. H.T. Chen, L.A. Schuler, R.D. Schultz, Growth hormone and Pit-1 expression in bovine fetal lymphoid cells. Dom. Anim. Endocrinol. 14, 399–407 (1997)

    Article  CAS  Google Scholar 

  68. V. De Mello-Coelho, M.C. Gagnerault, J.C. Souberbielle, C.J. Strasburger, W. Savino, M. Dardenne, M.C. Postel-Vinay, Growth hormone and its receptor are expressed in human thymic cells. Endocrinology 139, 3837–3842 (1998)

    Article  PubMed  Google Scholar 

  69. R. Kooijman, S. Gerlo, A. Coppens, E.L. Hooghe-Peters, Growth hormone and prolactin expression in the immune system. Ann. N. Y. Acad. Sci. 917, 534–540 (2000)

    Article  CAS  PubMed  Google Scholar 

  70. W.B. Malarkey, J. Wang, C. Cheney, R. Glaser, H. Nagaraja, Human lymphocyte growth hormone stimulates interferon gamma production and is inhibited by cortisol and norepinephrine. J. Neuroimmunol. 123, 180–187 (2002)

    Article  CAS  PubMed  Google Scholar 

  71. H. Wu, J. Wang, J.T. Cacioppo, R. Glaser, J.K. Kiecolt-Glaser, W.B. Malarkey, Chronic stress associated with spousal caregiving of patients with Alzheimer’s dementia is associated with downregulation of B-lymphocyte GH mRNA. J. Gerontol. A Biol. Sci. Med. Sci. 54, M212–M215 (1999)

    CAS  PubMed  Google Scholar 

  72. H. Wu, R. Devi, W.B. Malarkey, Localization of growth hormone messenger ribonucleic acid in the human immune system-a clinical research center study. J. Clin. Endocrinol. Metab. 81, 1278–1282 (1996)

    Article  CAS  PubMed  Google Scholar 

  73. S. Jeay, G.E. Sonenshein, M.C. Postel-Vinay, E. Baixeras, Growth hormone prevents apoptosis through activation of nuclear factor-kappa β in interleukin-3-dependent Ba/F3 cell line. Mol. Endocrinol. 14, 650–661 (2000)

    Article  CAS  PubMed  Google Scholar 

  74. E. Baixeras, S. Jeay, P.A. Kelly, M.C. Postel-Vinay, The proliferative and antiapoptotic actions of growth hormone and insulin-like growth factor-1 are mediated through distinct signaling pathways in the Pro-Ba/F3 cell line. Endocrinology 142, 2968–2977 (2001)

    Article  CAS  PubMed  Google Scholar 

  75. M. Luna, N. Barraza, L. Berumen, M. Carranza, E. Pedernera, S. Harvey, C. Aramburo, Heterogeneity of growth hormone immunoreactivity in lymphoid tissues and changes during ontogeny in domestic fowl. Gen. Comp. Endocrinol. 144, 28–37 (2005)

    Article  CAS  PubMed  Google Scholar 

  76. M. Luna, L. Huerta, L. Berumen, H. Martinez-Coria, S. Harvey, C. Aramburo, Growth hormone in the male reproductive tract of the chicken: heterogeneity and changes during ontogeny and maturation. Gen. Comp. Endocrinol. 137, 37–49 (2004)

    Article  CAS  PubMed  Google Scholar 

  77. M. Luna, A.J. Rodriguez-Mendez, L. Berumen, M. Carranza, J. Riesgo-Escovar, M.-L. Baudet, S. Harvey, C. Aramburo, Immune growth hormone (GH): localization of GH and GH mRNA in the bursa of Fabricius. Dev. Comp. Immunol. 32, 1313–1325 (2008)

    Article  CAS  PubMed  Google Scholar 

  78. A.J. Rodriguez-Mendez, J.L. Luna-Acosta, M. Carranza, S. Harvey, C. Aramburo, Growth hormone expression in stromal and non-stromal cells in the bursa of Fabricius during brusal development and involution: causal relationships? Gen. Comp. Endocrinol. 165, 297−307 (2010)

  79. K.L. Hull, S. Harvey, Growth hormone: roles in female reproduction. J. Endocrinol. 168, 1–23 (2001)

    Article  CAS  PubMed  Google Scholar 

  80. K.L. Hull, S. Harvey, GH as a co-gonadotropin: the relevance of correlative changes in GH secretion and reproductive state. J. Endocrinol. 172, 1–19 (2002)

    Article  CAS  PubMed  Google Scholar 

  81. K.L. Hull, S. Harvey, Growth hormone: a reproductive endocrine-paracrine regulator? Rev. Reprod. 5, 175–182 (2000)

    Article  CAS  PubMed  Google Scholar 

  82. K.L. Hull, S. Harvey, Growth hormone: roles in male reproduction. Endocrine 13, 243–250 (2000)

    Article  CAS  PubMed  Google Scholar 

  83. A.P. Nguyen, A. Chandorkar, C. Gupta, The role of growth hormone in fetal mouse reproductive tract differentiation. Endocrinology 137, 3659–3666 (1996)

    Article  CAS  PubMed  Google Scholar 

  84. F. Izadyar, J. Zhao, H.T. Van Tol, B. Colenbrander, M.M. Beavers, Messenger RNA expression and protein localization of growth hormone in bovine ovarian tissue and in cumulus oocytes complexes (COCs) during in vitro maturation. Mol. Reprod. Dev. 53, 398–406 (1999)

    Article  CAS  PubMed  Google Scholar 

  85. C. Mendoza, E. Ruiz-Requena, E. Ortega, N. Cremades, F. Martinez, R. Bernabeu, E. Greco, J. Tesarik, Follicular fluid markers of oocyte developmental potential. Hum. Reprod. 17, 1017–1022 (2002)

    Article  CAS  PubMed  Google Scholar 

  86. S. Modina, V. Borromeo, A.M. Luciano, V. Lodde, F. Francios, C. Secchi, Relationship between growth hormone concentrations in bovine oocytes and follicular fluid and oocyte developmental competence. Eur. J. Histochem. 51, 173–180 (2007)

    CAS  PubMed  Google Scholar 

  87. P. Schwartzler, G. Untergasser, M. Hermann, S. Dirnhofer, B. Abendstein, S. Madersbacher, P. Berger, Selective growth hormone/placental lactogen gene transcription and hormone production in pre- and postmenopausal human ovaries. J. Clin. Endocrinol. Metab. 82, 3337–3341 (1997)

    Article  Google Scholar 

  88. A. Hrabia, H.E. Paczoska-Eliasieicz, L.R. Berghman, S. Harvey, J. Rzasa, Expression and localization of growth hormone and its receptors in the chicken ovary during sexual maturation. Cell Tissue Res. 332, 317–328 (2008)

    Article  CAS  PubMed  Google Scholar 

  89. F. Izadyar, H.T. Van Tol, B. Colenbrander, M.M. Beavers, Stimulatory effect of growth hormone in vitro maturation of bovine oocytes is exerted through cumulus cells and not mediated by IGF-I. Mol. Reprod. Dev. 47, 175–180 (1997)

    Article  CAS  PubMed  Google Scholar 

  90. F. Izadyar, B. Colenbrander, M.M. Beavers, In vitro maturation of bovine oocytes in the presence of growth hormone accelerates nuclear maturation and promotes subsequent embryonic development. Mol. Reprod. Dev. 45, 372–377 (1996)

    Article  CAS  PubMed  Google Scholar 

  91. M.M. Beavers, F. Izadyar, Role of growth hormone and growth hormone receptor in oocyte maturatijon. Mol. Cell. Endocrinol. 197, 173–178 (2002)

    Article  Google Scholar 

  92. F. Izadyar, W.G. Hage, B. Colenbrander, M.M. Beavers, The promontory effect of growth hormone on the development competence of in vitro matured bovine is due to improved cytoplasmic maturation. Mol. Reprod. Dev. 49, 444–453 (1998)

    Article  CAS  PubMed  Google Scholar 

  93. N.R. Mtango, M.D. Varisanga, Y.J. Dong, R. Rajamahendran, T. Suzuki, Growth factors and growth hormone enhance in vitro embryo production and post-thaw survival of vitrified bovine blastocysts. Theriogenology 59, 1393–1402 (2003)

    Article  CAS  PubMed  Google Scholar 

  94. S. Chigioni, C. Secchi, V. Borromeo, S. Modina, M.S. Beretta, G.C. Luvoni, Effects of growth hormone on oocyte in vitro maturation and its localization in the canine cumulus-oocyte complexes. Vet. Res. Commun. 32, S131–S134 (2008)

    Article  PubMed  Google Scholar 

  95. A. Shirazi, N. Shams-Esfandabadi, E. Ahmadi, B. Heidari, Effects of growth hormone on nuclear maturation of ovine oocytes and subsequent embryo development. Reprod. Domest. Anim. 45, 530−536 (2010)

  96. E. Kiapekou, D. Loutradis, P. Drakakis, E. Zapanti, G. Mastorakos, A. Antsaklis, Effects of GH and IGF-I on the in vitro maturation of mouse oocytes. Hormones 4, 115–160 (2005)

    Google Scholar 

  97. R. Apa, A. Lanzone, F. Miceli, M. Mastrandrea, A. Caruso, S. Mancuso, R. Canipari, Growth hormone induces in vitro maturation of follicle- and cumulus-enclosed rat oocytes. Mol. Cell. Endocrinol. 106, 207–212 (1994)

    Article  CAS  PubMed  Google Scholar 

  98. Y. Yoshimura, Regulatory system and physiological significance of local factors in the ovary during follicular development and maturation. Nippon Janka Fujinka Gakkai Zasshi 47, 763–774 (1995)

    CAS  Google Scholar 

  99. S. Kolle, M. Stojkovic, G. Boie, E. Wolf, F. Sinowatz, Growth hormone-related effects on apoptosis, mitosis, and expression of connexin 43 on bovine in vitro maturation cumulus–oocyte complexes. Biol. Reprod. 68, 1584–1589 (2003)

    Article  CAS  PubMed  Google Scholar 

  100. N. Songsasen, I. Yu, S.P. Leibo, Nuclear maturation of canine oocytes cultured in protein-free media. Mol. Reprod. Dev. 62, 407–415 (2002)

    Article  CAS  PubMed  Google Scholar 

  101. S. Kolle, M. Stojkovic, G. Boie, E. Wolf, F. Sinowatz, Growth hormone inhibits apoptosis in in vitro produced bovine embryos. Mol. Reprod. Dev. 61, 180–186 (2002)

    Article  CAS  PubMed  Google Scholar 

  102. G.G. Kaiser, S. Kolle, G. Boie, F. Sinowatz, G.A. Palma, R.H. Alberio, In vivo effect of growth hormone on the expression of connexin-43 in bovine ovarian follicles. Mol. Reprod. Dev. 73, 600–606 (2006)

    Google Scholar 

  103. R. Marchal, M. Caillaud, A. Martoriati, N. Gerard, P. Mermillod, G. Goudet, Effects of growth hormone (GH) on in vitro nuclear and cytoplasmic oocyte maturation, cumulus expansion, hyaluronan synthases, and connexons 32 and 43 expression, and GH receptor messenger RNA expression in equine and porcine species. Biol. Reprod. 69, 1013–1022 (2003)

    Article  CAS  PubMed  Google Scholar 

  104. Y.J. Menezo, S. el Mouatassim, M. Chavrier, E.J. Servy, B. Nicolet, Human oocytes and preimplantation embryos express mRNA for growth hormone receptor. Zygote 11, 293–297 (2003)

    Google Scholar 

  105. Y.J. Menezo, B. Nivollet, J. Rollet, A. Hazout, Pregnancy and delivery after in vitro maturation of naked ICSI-GV oocytes with GH and transfer of a frozen thawed blastocyst: case report. J. Assist. Reprod. Genet. 23, 47–49 (2006)

    Article  PubMed  Google Scholar 

  106. F. Izadyar, H.T. Van Tol, W.G. Hage, M.M. Beavers, Preimplantation bovine embryos express mRNA of growth hormone receptor and respond to growth hormone addition during in vitro development. Mol. Reprod. Dev. 57, 247–255 (2000)

    Article  CAS  PubMed  Google Scholar 

  107. S. Kajimura, N. Kawaguchi, T. Kaneko, I. Kawazoe, T. Hirano, N. Visitacion, E.G. Grau, K. Aida, Identification of the growth hormone receptor in an advanced teleost, the tilapia (Oreochromis mossambicus) with special reference to its distinct expression pattern in the ovary. J. Endocrinol. 181, 65–76 (2004)

    Article  CAS  PubMed  Google Scholar 

  108. J.K. dePrada, C.A. VandeVoorte, Growth hormone and in vitro maturation of rhesus macaque oocytes and subsequent embryo development. Assist. Reprod. Genet. 25, 145–158 (2008)

    Article  Google Scholar 

  109. M. Slater, M. Cooper, C.R. Murphy, Human growth hormone and interleukin-6 are upregulated in endometriosis and endometrioid adenocarcinoma. Acta Histochem. 108, 13–18 (2006)

    Article  PubMed  Google Scholar 

  110. V. Pandey, J.K. Perry, K.M. Mohankumar, X.J. Kong, S.M. Liu, Z.S. Wu, M.D. Mitchell, T. Zhu, P.E. Lobie, Autocrine human growth hormone stimulates oncogenicity of endometrial carcinoma cells. Endocrinology 149, 3909–3919 (2008)

    Article  CAS  PubMed  Google Scholar 

  111. I.F. Sharara, D. Bhartiya, L.K. Nieman, Growth hormone receptor gene expression in the mouse uterus: modulation by gonadal steroids. J. Soc. Gynecol. Investig. 1, 285–289 (1994)

    CAS  PubMed  Google Scholar 

  112. R.A. Pershing, M.C. Lucy, W.W. Thatcher, L. Badinga, Effects of BST on oviductal and uterine genes encoding components of the IGF system in lactating daisy cows. J. Dairy Sci. 85, 3260–3267 (2002)

    Article  CAS  PubMed  Google Scholar 

  113. M.L. Rhoads, J.P. Meyer, S.J. Kolath, W.R. Lamberson, M.C. Lucy, Growth hormone receptor, insulin-like growth factor (IGF)-1, and IGF-binding protein-2 expression in the reproductive tissues of early postpartum dairy cows. J. Dairy Sci. 91, 1802–1813 (2008)

    Article  CAS  PubMed  Google Scholar 

  114. M. Sbracia, F. Scarpillini, R. Poverini, P.L. Alo, G. Rossi, U. Di Tondo, Immuno-histochemical localization of the growth hormone in human endometrium and decidua. Am. J. Reprod. Immunol. 51, 112–116 (2004)

    Article  PubMed  Google Scholar 

  115. C.R. Oliveira, R. Salvatori, L.M. Nobrega, E.O. Carvalho, M. Menezes, C.T. Farias, A.V. Britto, R.M. Pereira, M.H. Aguir-Oliveira, Sizes of abdominal organs in adults with severe short stature due to severe, untreated, congenital GH deficiency caused by a homozygous mutation in the GHRH receptor gene. Clin. Endocrinol. 69, 153–158 (2008)

    Article  CAS  Google Scholar 

  116. D. Stygar, N. Muravitskaya, B. Eriksson, H. Eriksson, L. Sahlin, Effects of SERM (selective estrogen receptor modulator) treatment on growth and proliferation in the rat uterus. Reprod. Biol. Endocrinol. 7, 1–40 (2003)

    Google Scholar 

  117. S. Kolle, F. Sinowatz, G. Boie, D. Lincoln, M.J. Waters, Differential expression of the growth hormone receptor and its transcript in bovine uterus and placenta. Mol. Cell. Endocrinol. 131, 127–136 (2001)

    Article  Google Scholar 

  118. D. Zaczek, J. Hammond, L. Suen, S. Wandji, D. Service, A. Bartke, V. Chandrasheka, K. Coschigano, J. Kopchick, Impact of growth hormone resistance on female reproductive function: new insights from growth hormone receptor knockout mice. Biol. Reprod. 67, 1115–1124 (2002)

    Article  CAS  PubMed  Google Scholar 

  119. E. van Garderen, M. de Wit, W.F. Voorhout, G.R. Rutteman, J.A. Mol, H. Nedergragt, W. Misdorp, Expression of growth hormone in canine mammary tissue and mammary tumors. Am. J. Pathol. 150, 1037–1047 (1997)

    PubMed  Google Scholar 

  120. J.A. Mol, I.S. Lantinga-van Leeuwen, E. van Garderen, P.J. Selman, M.A. Oosterlaken-Dijksterhuis, J.A. Schalken, A. Rijnberk, Mammary growth hormone and tumorigenesis-lessons from the dog. Vet. Q. 21, 111–115 (1999)

    CAS  PubMed  Google Scholar 

  121. J.A. Mol, I. Lantinga-van Leeuwen, E. van Garderen, A. Rijnberk, Progestin-induced mammary growth hormone (GH) production. Adv. Exp. Med. Biol. 480, 71–76 (2000)

    Article  CAS  PubMed  Google Scholar 

  122. M. Raccurt, P.E. Lobie, E. Moudilou, T. Garcia-Caballero, L. Frappart, G. Morel, H.C. Mertani, High stromal and epithelial human GH gene expression is associated with proliferative disorders of the mammary gland. J. Endocrinol. 175, 307–318 (2002)

    Article  CAS  PubMed  Google Scholar 

  123. S. Mukhina, D. Liu, K. Guo, M. Raccurt, S. Borges-Bendris, H.C. Mertani, P.E. Lobie, Autocrine growth hormone prevents lactogenic differentiation of mouse mammary epithelial cells. Endocrinology 147, 1819–1829 (2006)

    Article  CAS  PubMed  Google Scholar 

  124. I. Schoenmakers, H.S. Kooistra, A.C. Okkens, H.A. Hazewinkel, M.M. Bevers, J.A. Mol, Growth hormone concentrations in mammary secretions and plasma of the peripaturient bitch and in plasma of the neonate. J. Reprod. Fertil. Suppl. 51, 363–367 (1997)

    CAS  PubMed  Google Scholar 

  125. S.F. Bhatti, L. Duchateu, A.C. Okkens, L.M. Van Ham, J.A. Mol, H.S. Kooistra, Treatment of growth hormone excess in dogs with the progesterone receptor antagonist alglepristone. Theriogenology 66, 797–803 (2007)

    Article  CAS  Google Scholar 

  126. C. Gil-Puig, S. Seoane, M. Blanco, M. Macia, T. Garcia-Caballero, C. Segura, R. Perez-Fernandez, Pit-1 is expressed in normal and tumorous human breast and regulates GH secretion and cell proliferation. Eur. J. Endocrinol. 153, 335–344 (2005)

    Article  CAS  PubMed  Google Scholar 

  127. H.S. Kooistra, G. Voorhout, P.J. Selman, A. Rijnberk, Progestin-induced growth hormone (GH) production in the treatment of dogs with congenital GH deficiency. Domest. Anim. Endocrinol. 15, 93–102 (1998)

    Article  CAS  PubMed  Google Scholar 

  128. E.L. Gregoraszczuk, T. Milewicz, J. Kolodziejczyk, J. Krzysiek, A. Basta, K. Sztefko, S. Kurek, J. Stachura, Progesterone-induced secretion of growth hormone, insulin-like growth factor I and prolactin by human breast cancer explants. Gynecol. Endocrinol. 15, 251–258 (2001)

    CAS  PubMed  Google Scholar 

  129. W.M. Lee, H.S. Kooistra, J.A. Mol, S.J. Dieleman, A.C. Schaefers-Okkens, Ovariectomy during the luteal phase influences secretion of prolactin, growth hormone, and insulin-like growth factor-I in the bitch. Theriogenology 66, 484–490 (2006)

    Article  CAS  PubMed  Google Scholar 

  130. I.S. Lantinga van Leeuwen, E. van Garderen, G.R. Rutteman, J.A. Mol, Cloning and cellular localization if the canine progesterone receptor: co-localization with growth hormone in the mammary gland. J. Steroid Biochem. Mol. Biol. 75, 219–228 (2000)

    Article  CAS  PubMed  Google Scholar 

  131. E. van Garderen, H.J. van der Poel, J.F. Swennenhuis, E.H. Wissink, G.R. Rutteman, E. Hellmen, J.A. Mol, J.A. Schalken, Expression and molecular characterization of the growth hormone receptor in canine mammary tissue and mammary tumors. Endocrinology 140, 5907–5914 (1999)

    Article  PubMed  Google Scholar 

  132. F. Sinowatz, D. Schams, S. Kolle, A. Plath, D. Lincoln, M.J. Waters, Cellular localization of GH receptors in the bovine mammary gland during mammogenesis, lactation and involution. J. Endocrinol. 166, 503–510 (2000)

    Article  CAS  PubMed  Google Scholar 

  133. A. Plath-Gabler, C. Gabler, F. Sinowatz, B. Berisha, D. Schams, The expression of the IGF family and GH receptor in the bovine mammary gland. J. Endocrinol. 168, 39–48 (2001)

    Article  CAS  PubMed  Google Scholar 

  134. E. van Garderen, J.A. Schalken, Morphogenic and tumorigenic potentials of the mammary growth hormone/growth hormone receptor system. Mol. Cell. Endocrinol. 197, 153–165 (2002)

    Article  PubMed  Google Scholar 

  135. J. Divisova, I. Kuiatse, Z. Lazard, H. Weiss, F. Vreeland, D.L. Hadsell, R. Schiff, C.K. Osborne, A.V. Lee, The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth. Breast Cancer Res. Treat. 98, 315–327 (2006)

    Article  CAS  PubMed  Google Scholar 

  136. P.A. Kelly, A. Bachelot, C. Kedzia, L. Hennighausen, C.J. Ormandy, J.J. Kopchick, N. Binart, The role of prolactin and growth hormone in mammary gland development. Mol. Cell. Endocrinol. 197, 127–131 (2002)

    Article  CAS  PubMed  Google Scholar 

  137. J.F. Trott, B.K. Vonderhaar, R.C. Hovey, Historical perspectives of prolactin and growth hormone as mammogens, lactogens and galactogogues-agog for the future!. J. Mammary Gland Biol. Neoplasia 13, 3–11 (2008)

    Article  PubMed  Google Scholar 

  138. S. Mukhina, H.C. Mertani, K. Guo, K.O. Lee, P.D. Gluckman, P.E. Lobie, Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone. Proc. Natl Acad. Sci. 101, 15166–15171 (2004)

    Article  CAS  PubMed  Google Scholar 

  139. C.L. Boguszewski, P.A. Svensson, T. Jansson, R. Clark, L.M. Carlsson, B. Carlsson, Cloning of two novel growth hormone transcripts expressed in human placenta. J. Clin. Endocrinol. Metab. 83, 2878–2885 (1998)

    Article  CAS  PubMed  Google Scholar 

  140. M.C. Lacroix, J. Guibourdenche, J.L. Frendo, G. Pidoux, D. Evain-Brion, Placental growth hormones. Endocrine 19, 73–79 (2002)

    Article  CAS  PubMed  Google Scholar 

  141. J. Fuglsang, P. Ovesen, Aspects of placental growth hormone physiology. Growth Horm. IGF Res. 16, 67–85 (2006)

    Article  CAS  PubMed  Google Scholar 

  142. D. Haig, Placental growth hormone-related proteins and prolactin-related proteins. Placenta 22, S36–S41 (2008)

    Article  CAS  Google Scholar 

  143. T.G. Golos, M. Durning, J.M. Fisher, P.D. Fowler, Cloning of four growth hormone/chorionic somatomammotropin-related complementary deoxyribonucleic acids differentially expressed during pregnancy in the rhesus monkey placenta. Endocrinology 133, 1744–1752 (1993)

    Article  CAS  PubMed  Google Scholar 

  144. C. Ye, Y. Li, P. Shi, Y.P. Zhang, Molecular evolution of growth hormone gene family in old world monkeys and hominoids. Gene 350, 183–192 (2005)

    Article  CAS  PubMed  Google Scholar 

  145. O.C. Wallis, M. Wallis, Evolution of growth hormone in primates: the GH gene clusters of the New World monkeys marmoset (Callithrix jacchus) and while-fronted capuchin (Cebus albifrons). J. Mol. Evol. 63, 591–601 (2006)

    Article  CAS  PubMed  Google Scholar 

  146. J. Lin, J. Poole, D.I. Liner, Two novel members of the prolactin/growth hormone family are expressed in the mouse placenta. Endocrinology 138, 5535–5540 (1997)

    Article  CAS  PubMed  Google Scholar 

  147. K. Ishibashi, M. Imai, Identification of four new members of the rat prolactin/growth hormone gene family. Biochem. Biophys. Res. Commun. 262, 575–578 (1999)

    Article  CAS  PubMed  Google Scholar 

  148. M.C. Lacroix, E. Devinoy, J.L. Servely, C. Puissant, G. Kann, Expression of the growth hormone gene in ovine placenta: detection and cellular localization of the protein. Endocrinology 137, 4886–4892 (1996)

    Article  CAS  PubMed  Google Scholar 

  149. M.C. Lacroix, E. Devinoy, S. Cassy, J.L. Servely, M. Vidaud, G. Kann, Expression of growth hormone and its receptor in the placental and feto-maternal environment during early pregnancy in sheep. Endocrinology 140, 5587–5597 (1999)

    Article  CAS  PubMed  Google Scholar 

  150. M. Wallis, A. Lioupis, O.C. Wallis, Duplicate growth hormone genes in sheep and goat. J. Mol. Endocrinol. 21, 1–5 (1998)

    Article  CAS  PubMed  Google Scholar 

  151. E. Gootwine, Placental hormones and fetal-placental development. Anim. Reprod. Sci. 82–83, 551–566 (2004)

    Article  PubMed  CAS  Google Scholar 

  152. X. Ma, X. Liu, Y. Zhang, P. Zhu, W. Ye, H. Lin, Two growth hormone receptors in Nile tilapia (Oreochromis niloticus): molecular characterization, tissue distribution and expression profiles in the gonad during the reproductive cycle. Comp. Biochem. Physiol. B: Biochem. Mol. Biol. 147, 325–339 (2007)

    Article  CAS  Google Scholar 

  153. L.K. Davis, A.L. Peirce, N. Hiramatsu, C.V. Sullivan, T. Hirano, E.G. Grau, Gender-specific expression of multiple estrogen receptors, growth hormone receptors, insulin-like growth factors and vitellogenins, and effects of 17 beta-estradiol in the male tilapia (Oreochromis mossambicus). Gen. Comp. Endocrinol. 156, 544–551 (2008)

    Article  CAS  PubMed  Google Scholar 

  154. P.E. Lobie, W. Breipohl, J.G. Aragon, M.J. Waters, Cellular localization of the growth hormone receptor/binding protein in the male and female reproductive systems. Endocrinology 126, 2214–2221 (1990)

    Article  CAS  PubMed  Google Scholar 

  155. M.R. N’Diaye, S.S. Sun, S.P. Fanua, K.J. Loseth, E.F. Shaw Wilgis, B.G. Crabo, Growth hormone receptors in the porcine testis during prepuberty. Reprod. Domest. Anim. 37, 305–309 (2002)

    Article  PubMed  Google Scholar 

  156. E.B. Berensztein, M.S. Baquedano, C.M. Pepe, M. Costanzo, N.I. Saraco, R. Ponzio, M.A. Rivarola, A. Blgorosky, Role of IGFs and insulin in the human testis during postnatal activation: differentiation of steroidogenic cells. Pediatr. Res. 63, 662–666 (2008)

    Article  CAS  PubMed  Google Scholar 

  157. Z.J. Champion, M.H. Vickers, C.G. Gravance, B.H. Breier, P.J. Casey, Growth hormone or insulin-like growth factor-I extends longevity of equine spermatozoa in vitro. Theriogenology 57, 1793–1800 (2002)

    Article  CAS  PubMed  Google Scholar 

  158. J.F. Roser, Regulation of testicular function in the stallion: an intricate network of endocrine, paracrine and autocrine systems. Anim. Reprod. Sci. 107, 179–196 (2008)

    Article  CAS  PubMed  Google Scholar 

  159. G. Untergasser, W. Kranewitter, F. Walser, S. Madersbacher, S. Dirnhofer, P. Berger, The testis as eutopic production site of human growth hormone, placental lactogen and prolactin: possible autocrine/paracrine effects on testicular function. Wien. Klin. Wochenschr. 108, 541–546 (1996)

    CAS  PubMed  Google Scholar 

  160. G. Untergasser, W. Kranewitter, P. Schwarzler, S. Madersbacher, S. Dirnhofer, P. Berger, Organ-specific expression pattern of the human growth hormone/placental lactogen gene-cluster in the testis. Mol. Cell. Endocrinol. 130, 53–60 (1997)

    Article  CAS  PubMed  Google Scholar 

  161. P. Berger, G. Untergasser, M. Hermann, A. Hittmair, S. Madersbacher, S. Dinhofer, The testis-speicific expression pattern of the growth hormone/placental (GH/PL) gene cluster changes with malignancy. Hum. Pathol. 30, 1201–1206 (1999)

    Article  CAS  PubMed  Google Scholar 

  162. A.A. Sciara, J.A. Rubiolo, G.M. Somozoa, S.E. Arranz, Molecular cloning, expression and immunological characterization of prejerrey (Odontesthes bonariensis) growth hormone. Comp. Biochem. Physiol. C: Toxicol. Pharamacol. 142, 284–292 (2006)

    Article  CAS  Google Scholar 

  163. A.L. Filby, C.R. Tyler, Cloning and characterization of cDNAs for hormones and/or receptors of growth hormone, insulin-like growth factor-I, thyroid hormone, and corticosteroid and the gender-, tissue-, and developmental-specific expression of their mRNA transcripts in fathead minnow (Pimephales promelas). Gen. Comp. Endocrinol. 150, 151–163 (2007)

    Article  CAS  PubMed  Google Scholar 

  164. S. Harvey, M.-L. Baudet, A.E. Murphy, M. Luna, K.L. Hull, C. Aramburo, Testicular growth hormone (GH): GH expression in spermatogonia and primary spermatocytes. Gen. Comp. Endocrinol. 139, 158–167 (2004)

    Article  CAS  PubMed  Google Scholar 

  165. M.D. Slater, C.R. Murphy, Co-expression of interleukin-6 and human growth hormone in apparently normal prostate biopsies that ultimately progress to prostate cancer using low pH, high temperature antigen retrieval. J. Mol. Hist. 37, 37–41 (2006)

    Article  CAS  Google Scholar 

  166. C.V. Kyle, M.C. Evans, W.D. Odell, Growth hormone-like material in normal human tissues. J. Clin. Endocrinol. Metab. 53, 1138–1144 (1981)

    Article  CAS  PubMed  Google Scholar 

  167. A. Costa, G. Zoppetti, C. Benedetto, E. Bertino, L. Marozio, C. Fabris, R. Arisio, G.F. Giraudi, O. Testori, M. Ariano, V. Maula, E. Bertini, Immunolike growth hormone substance in tissues from human embryos/fetuses and adults. J. Endocrinol. Invest. 16, 625–633 (1993)

    CAS  PubMed  Google Scholar 

  168. R. Sundler, J. Alumets, R. Hakanson, Growth hormone-like immunoreactivity in gastrin cells and gastrinomas. Histochemistry 59, 343–356 (1979)

    Article  CAS  PubMed  Google Scholar 

  169. Q.S. Pan, Z.P. Fang, F.J. Huang, Identification, localization and morphology of APUD cells in gastroenteropancreatic system of stomach containing teleosts. World J. Gastroenterol. 6, 842–847 (2000)

    PubMed  Google Scholar 

  170. J.H. Robben, E. van Garderen, J.A. Mol, J. Wolfswinkel, A. Rijnberk, Locally produced growth hormone in canine insulinomas. Mol. Cell. Endocrinol. 197, 187–195 (2002)

    Article  CAS  PubMed  Google Scholar 

  171. N.M. Very, J.D. Kittilson, L.A. Norbeck, M.A. Heridan, Isolation, characterization, and distribution of two cDNAs encoding for growth hormone receptor in rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. B: Biochem. Mol. Biol. 140, 615–628 (2005)

    Article  CAS  Google Scholar 

  172. T.C. Brelje, L.E. Stout, N.V. Bhagroo, R.L. Sorenson, Distinctive roles for prolactin and growth hormone in the activation of signal transducer and activator of transcription 5 in pancreatic islets of Langerhans. Endocrinology 145, 4162–4175 (2004)

    Article  CAS  PubMed  Google Scholar 

  173. Q. Zhang, M. Kohler, S.N. Yang, F. Zhang, O. Larsson, P.O. Berggren, Growth hormone promotes Ca(2+)-induced Ca2+ release in insulin-secreting cells by ryanodine receptor tyrosine phosphorylation. Mol. Endocrinol. 18, 1658–1669 (2004)

    Article  CAS  PubMed  Google Scholar 

  174. A.O. Gurol, G. Yillar, A.O. Kursun, B. Kiran, E. Aktas, S. Salman, G. Deniz, M.T. Yilmaz, Effect of human Somatotropin hormone on cultured rat islets. Transplant. Proc. 36, 1613–1614 (2004)

    Article  CAS  PubMed  Google Scholar 

  175. B. Granados, C. Ariznavarreta, J.A.P. Tresguerres, Adrenal and parotid tissue autotransplantation to the sell turcica are able to partially recover gonadotropic function in hypophysectomized rats. J. Endocrinol. Invest. 16, 116 (1993)

    Google Scholar 

  176. P. Fernandez, B. Granados, C. Ariznavarreta, A. Rodriguez-Ramos, P. Gil-Loyzaga, J.A.F. Tresguerres, Rat parotid gland tissue is able to assume pituitary functions under hypothalamic extracts in culture. Neuroendocrinology 60, 36 (1994)

    Article  Google Scholar 

  177. J.A. Tresguerres, C. Ariznavarreta, B. Granados, J.A. Costoya, A. Perez-Romero, F. Salame, M. Hermanussen, Salivary gland is capable of GH synthesis under GHRH stimulation. J. Endocrinol. 160, 217–222 (1999)

    Article  CAS  PubMed  Google Scholar 

  178. A. Perez-Romero, E. Dialynas, F. Salame, A. Amores, L. Vidarte, A. Bartke, C. Ariznavarreta, J.A. Tresguerres, GH gene expression in the submaxillary gland in normal and Ames dwarf mice. J. Endocrinol. 169, 389–396 (2001)

    Article  CAS  PubMed  Google Scholar 

  179. W.G. Yong, G.O. Ramirez-Yanez, T.J. Daley, J.R. Smid, K.T. Coshigano, J.J. Kopchick, M.J. Waters, Growth hormone and epidermal growth factor in salivary glands of giant and dwarf transgenic mice. J. Histochem. Cytochem. 52, 1191–1197 (2004)

    Article  CAS  Google Scholar 

  180. T. Mori, R.H. Devlin, Transgene and host growth hormone gene expression in pituitary and non-pituitary tissues of normal and growth hormone salmon. Mol. Cell. Endocrinol. 149, 129–139 (1999)

    Article  CAS  PubMed  Google Scholar 

  181. C. Ohlsson, B.A. Bengtsson, O.G. Isaksson, T.T. Andreassen, M.C. Slootweg, Growth hormone and bone. Endocr. Rev. 19, 55–79 (1998)

    Article  CAS  PubMed  Google Scholar 

  182. T. Ueland, Bone metabolism in relation to alterations in systemic growth hormone. Growth Horm. IGF Res. 14, 404–417 (2004)

    CAS  PubMed  Google Scholar 

  183. T. Ueland, GH/IGF-1 and bone resorption in vivo and in vitro. Eur. J. Endocrinol. 152, 327–332 (2005)

    Article  CAS  PubMed  Google Scholar 

  184. B.C. van der Eerden, M. Karperien, J.M. Wit, Systemic and local regulation of the growth plate. Endocr. Rev. 24, 782–801 (2003)

    Article  PubMed  CAS  Google Scholar 

  185. S. Mohan, C. Richman, R. Guo, Y. Amaar, L.R. Donahue, J. Wergedal, D.J. Bayling, Insulin-like growth factor regulates peak bone mineral density in mice by both growth hormone-dependent and -independent mechanism. Endocrinology 144, 929–936 (2003)

    Article  CAS  PubMed  Google Scholar 

  186. J. Wang, J. Zhou, C.M. Cheng, J.J. Kopchick, C.A. Bondy, Evidence supporting dual, IGF-I-independent and IGF-I-dependent, roles for GH in promoting longitudinal bone growth. J. Endocrinol. 180, 247–255 (2004)

    Article  CAS  PubMed  Google Scholar 

  187. O. Nilsson, R. Marino, F. De Luca, M. Phillip, J. Baron, Endocrine regulation of the growth plate. Horm. Res. 64, 157–165 (2005)

    Article  CAS  PubMed  Google Scholar 

  188. O. Isaksson, GH, IGF-I and growth. J. Pediatr. Endocrinol. Metab. 4, 1321–1326 (2004)

    Google Scholar 

  189. O.G. Isaksson, J.O. Jansson, I.A. Gause, Growth hormone stimulates longitudinal bone growth directly. Science 216, 1237–1239 (1982)

    Article  CAS  PubMed  Google Scholar 

  190. J. Isgaard, C. Moller, O.G. Isaksson, A. Nilsson, L.S. Mathews, G. Norstedt, Regulation of insulin-like growth factor messenger ribonucleic acid in rat growth plate by growth hormone. Endocrinology 122, 1515–1520 (1988)

    Article  CAS  PubMed  Google Scholar 

  191. N.L. Schlechter, S.M. Russell, E.M. Spencer, C.S. Nicoll, Evidence suggesting that the direct growth-promoting effect of growth hormone on cartilage in vivo is mediated by local production of somatomedin. Proc. Natl Acad. Sci. USA 83, 7932–7934 (1986)

    Article  CAS  PubMed  Google Scholar 

  192. T.T. Andreassen, H. Oxlund, The effects of growth hormone on cortical and cancellous bone. J. Musculoskelet. Neuronal Interact. 2, 49–58 (2001)

    CAS  PubMed  Google Scholar 

  193. K. De Jesus, X. Wang, J.L. Liu, A general IGF-I overexpression effectively rescued somatic growth and bone deficiency in mice caused by growth hormone receptor knockout. Growth Factors 27, 438–447 (2009)

    Article  PubMed  CAS  Google Scholar 

  194. C.W. Denko, B. Boja, C.J. Malemud, Intra-erythrocyte deposition of growth hormone in rheumatic diseases. Rheumatol. Int. 23, 11–14 (2003)

    CAS  PubMed  Google Scholar 

  195. W.C. Denko, C.J. Malemud, Role of the growth hormone/insulin-like growth factor-I paracrine axis in rheumatic diseases. Semin. Arthritis Rheum. 35, 24–34 (2005)

    Article  CAS  PubMed  Google Scholar 

  196. O.G. Isaksson, C. Ohlsson, A. Nilsson, J. Isgaard, A. Lindahl, Regulation of cartilage growth by growth hormone and insulin-like factor I. Pediatr. Nephrol. 5, 451–453 (1991)

    Article  CAS  PubMed  Google Scholar 

  197. V.H. Heemskerk, M.A. Daemen, W.A. Buurman, Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation. Cyt. Growth Factor Rev. 10, 5–14 (1999)

    Article  CAS  Google Scholar 

  198. F. Silveri, P. Morosini, D. Brecciaroli, C. Cervini, Intra-articular injection of somatostatin in knee osteoarthritis: clinical results and IGF-1 serum levels. Int. J. Clin. Pharamacol. Res. 14, 79–85 (1994)

    CAS  Google Scholar 

  199. F. Silveri, C. Lo Barco, D. Brecciaroli, Somatostatin in peri-arthropathies of the shoulder: clinical effectiveness and tolerability after sub-acromial administration. Clin. Ter. 148, 75–81 (1997)

    CAS  PubMed  Google Scholar 

  200. G. Coatri, M. Di Franco, A. Iagnocco, M.R. Di Novi, M.T. Mauceri, A. Copcco, Intra-articular somatostatin 14 reduces synovial thickness in rheumatoid arthritis: an ultrasonographic study. Int. J. Clin. Pharmacol. Res. 15, 27–32 (1995)

    Google Scholar 

  201. C. Fernandez-Criado, A. Martos-Rodriogiez, I. Santos-Alvarex, J.P. Garcia-Ruiz, E. Delgado-Baeza, The fate of chondrocyte in osteroarthritic cartilage of transgenic mice expressing bovine GH. Osteoarthr. Cartil. 12, 543–551 (2004)

    Article  CAS  PubMed  Google Scholar 

  202. C.Z. Zhang, H. Li, W.G. Young, P.M. Bartold, C. Chen, M.J. Waters, Evidence for a local action of growth hormone in embryonic tooth development in the rat. Growth Factors 14, 131–143 (1997)

    Article  CAS  PubMed  Google Scholar 

  203. W.G. Young, C.Z. Zhang, H. Li, P. Osborne, M.J. Waters, The influence of growth hormone on cell proliferation in odontogenic epithelia by bromodeoxyuridine immunocytochemistry and morphometry in the Lewis dwarf rat. J. Dent. Res. 71, 1807–1811 (1992)

    CAS  PubMed  Google Scholar 

  204. W.G. Young, J.V. Ruch, M.R. Stevens, C. Begue-Kirn, C.Z. Zhang, H. Lesot, Comparison of the effects of growth hormone, insulin-like growth fctor-1 and fetal calf serum on mouse molar odontogenesis in vitro. Arch. Oral Biol. 40, 789–799 (1995)

    Article  CAS  PubMed  Google Scholar 

  205. W.G. Young, H. Li, Y. Xiao, M.J. Waters, P.M. Bartold, Growth hormone-stimulated dentinogenesis in Lewis dwarf rat molars. J. Dent. Res. 80, 1742–1747 (2001)

    Article  CAS  PubMed  Google Scholar 

  206. J.R. Smid, J.E. Rowland, W.G. Young, K.T. Coschigano, J.J. Kopochick, M.J. Waters, Mouse molar dentin size/shape is dependent on growth hormone status. J. Dent. Res. 86, 463–468 (2007)

    Article  CAS  PubMed  Google Scholar 

  207. J.R. Smid, J.E. Rowland, W.G. Young, T.J. Daley, K.T. Coschigano, J.J. Kopochick, M.J. Waters, Mouse cellular cementum is highly dependent on growth hormone status. J. Dent. Res. 83, 35–39 (2004)

    Article  CAS  PubMed  Google Scholar 

  208. H. Li, P.M. Bartold, C.Z. Zhang, R.W. Clarkson, W.G. Young, M.J. Waters, Growth hormone and insulin-like growth factor-I induce bone morphogenetic proteins 2 and 4: a mediator role in bone and tooth formation. Endocrinology 139, 3855–3862 (1998)

    Article  CAS  PubMed  Google Scholar 

  209. H. Li, P.M. Bartold, W.G. Young, Y. Xiao, M.J. Waters, Growth hormone induces bone morphogenetic proteins and bone-related proteins in the developing rat periodontium. J. Bone Miner. Res. 16, 1068–1076 (2001)

    Article  CAS  PubMed  Google Scholar 

  210. A. Slominski, W.B. Malarkey, J. Wortsman, S.L. Asa, A. Carlson, Human skin expression growth hormone but not the prolactin gene. J. Lab. Clin. Med. 136, 476–481 (2000)

    Article  CAS  PubMed  Google Scholar 

  211. A. Palmetshofer, D. Zechner, T.A. Lugerf, A. Barta, Splicing variants of the human growth hormone mRNA: detection in pituitary, mononuclear cells and dermal fibroblasts. Mol. Cell. Endocrinol. 113, 225–234 (1995)

    Article  CAS  PubMed  Google Scholar 

  212. S.R. Oakes, K.M. Haynes, M.J. Waters, A.C. Herington, G.A. Werther, Demonstration and localization of growth hormone receptor in human skin and skin fibroblasts. J. Clin. Endocrinol. Metab. 75, 1368–1373 (1992)

    Article  CAS  PubMed  Google Scholar 

  213. A. Tavakkol, J.T. Elder, C.E. Griffiths, K.D. Cooper, H. Talwar, G.J. Fisher, K.M. Keane, S.K. Foltin, J.J. Voorhees, Expression of growth hormone receptor, insulin-like growth factor 1 (IGF-1) and IGF-1 receptor mRNA and proteins in human skin. J. Invest. Dermatol. 99, 343–349 (1992)

    Article  CAS  PubMed  Google Scholar 

  214. M. Ginarte, T. Garcia-Caballero, V. Fernandez-Redondo, A. Beiras, J. Toribio, Expression of growth hormone receptor in benign and malignant cutaneous proliferative entities. J. Cutan. Pathol. 27, 276–282 (2000)

    Article  CAS  PubMed  Google Scholar 

  215. M. Sheffield-Moore, R.J. Urban, An overview of the endocrinology of skeletal muscle. Trends Endocrinol. Metab. 15, 111–115 (1994)

    Google Scholar 

  216. H.B. Segard, S. Moulin, S. Boumard, C. Augier de Cremiers, P.A. Kelly, J. Finidori, Autocrine growth hormone production prevents apoptosis and inhibits differentiation in C2C12 myoblasts. Cell. Signal. 15, 612–615 (2003)

    Article  CAS  Google Scholar 

  217. J.A. Beyea, D.M. Olson, R.A. Vandergriend, S. Harvey, Expression of growth hormone and its receptor in the lungs of embryonic chicks. Cell Tissue Res. 322, 379–392 (2005)

    Article  CAS  PubMed  Google Scholar 

  218. J. Isgaard, A. Tivesten, P. Friberg, B.A. Bengtsson, The role of the GH/IGF-I axis for cardiac function and structure. Horm. Metab. Res. 31, 50–54 (1999)

    Article  CAS  PubMed  Google Scholar 

  219. J. Svensson, A. Tivesten, J. Isgaard, Growth hormone and cardiovascular function. Min. Endocrinol. 30, 1–13 (2005)

    CAS  Google Scholar 

  220. A. Caelers, N. Maclean, G. Hwang, G.E. Eppler, M. Reinecke, Expression of endogenous and exogenous growth hormone (GH) messenger (m) RNA in a GH-transgenic tilapia (Oreochromis niloticus). Transgenic Res. 14, 95–104 (2005)

    Article  CAS  PubMed  Google Scholar 

  221. J. Beyea, D.M. Olson, S. Harvey, Growth hormone-dependent changes in rat lung proteome during alveorization. Mol. Cell. Biochem. 321, 197–204 (2009)

    Article  CAS  PubMed  Google Scholar 

  222. A.T. Allen, C.A. Bloor, R.K. Kedia, R.A. Knight, M.A. Spiteri, Expression of growth hormone-releasing factor, growth hormone, insulin-like growth factor-1 and its binding proteins in human lung. Neuropeptides 34, 98–107 (2000)

    Article  CAS  PubMed  Google Scholar 

  223. J. Beyea, G. Sawicki, D.M. Olson, E. List, J.J. Kopchick, S. Harvey, Growth hormone (GH) receptor knockout mice reveal actions of GH in lung development. Proteomics 6, 341–348 (2006)

    Article  CAS  PubMed  Google Scholar 

  224. J. Beyea, D.M. Olson, S. Harvey, Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression. Dev. Dyn. 234, 404–412 (2005)

    Article  CAS  PubMed  Google Scholar 

  225. P. Klilerich, K. Kristiansen, S.S. Madsen, Hormone receptors in gills of smolting Atlantic salmon, Salmo salar: expression of growth hormone, prolactin, mineralocorticoids, and glucocorticoid receptors and 11beta-hydroxysteriod dehydrogenase type 2. Gen. Comp. Endocrinol. 152, 295–303 (2007)

    Article  CAS  Google Scholar 

  226. K.M. Meier, M.A. Figueiredo, M.T. Kamimura, J. Laurino, R. Maggioni, L.S. Pinto, O.A. Dellagostin, M.B. Tesser, L.A. Sampaio, L.F. Marins, Increased growth hormone (GH), growth hormone receptor (GHR), and insulin-like factor I (IGF-I) gene transcription after hyperosmotic stress in the Brazilian flounder Paralichthys orbignyanus. Fish Physiol. Biochem. 35, 501–509 (2008)

    Article  PubMed  CAS  Google Scholar 

  227. S. Tomy, Y.M. Chang, Y.H. Chen, J.C. Cao, T.P. Want, C.F. Chang, Salinity effects on the expression of osmoregulatory genes in the euryhaline black progy Acanthopagrus schlegeli. Gen. Comp. Endocrinol. 161, 123–132 (2009)

    Article  CAS  PubMed  Google Scholar 

  228. T. Sakamoto, T. Hirano, Growth hormone receptors in the liver osmoregulatory organs of rainbow trout: characterization and dynamics during adaptation to seawater. J. Endocrinol. 130, 425–433 (1991)

    Article  CAS  PubMed  Google Scholar 

  229. M. Pantaleon, E.J. Whiteside, M.B. Harvey, R.T. Barnard, M.J. Waters, P.L. Kaye, Functional growth hormone (GH) receptors and GH are expressed by preimplantation mouse embryos: a role for GH in early embryogenesis? Proc. Natl Acad. Sci. 94, 5125–5130 (1997)

    Article  CAS  PubMed  Google Scholar 

  230. S. Kolle, M. Stojkovic, K. Prelle, M. Waters, E. Wolf, F. Sinowatz, Growth hormone (GH)/GH receptor expression and GH-mediated effects during early bovine embryogenesis. Biol. Reprod. 64, 1826–1834 (2001)

    Article  CAS  PubMed  Google Scholar 

  231. K.E. Markham, P.L. Kaye, Growth hormone, insulin-like factor I and cell proliferation in the mouse blastocyst. Reproduction 125, 327–336 (2003)

    Article  CAS  PubMed  Google Scholar 

  232. A. Revol, M.L. Garza Rodriguez, V. Hernandez Montenegro, C. Aguilera, H. Barrera Saldana, R. Mendoza, Cloning of growth hormone cDNA of alligator gar Atractosteus spatula and its expression through larval development. Comp. Biochem. Phsyiol. A: Mol. Integr. Physiol. 140, 423–429 (2005)

    Article  CAS  Google Scholar 

  233. M. Li, J. Greenway, J. Petrik, A. Hahnel, J. Leatherland, Growth hormone and insulin-like growth factor gene expression prior to the development of the pituitary gland in rainbow trout (Oncorhynchus mykiss) embryos reared at two temperatures. Physiol. A: Mol. Integr. Physiol. 143, 514–522 (2006)

    Google Scholar 

  234. M. Li, J.C. Raine, J.F. Leatherland, Expression profiles of growth-related genes during the very early development of rainbow trout embryos reared at two incubation temperatures. Gen. Comp. Endocrinol. 153, 302–310 (2007)

    Article  CAS  PubMed  Google Scholar 

  235. J.C. Gabillard, H. Duval, C. Cauty, P.Y. Rescan, C. Weil, P.Y. Le Bail, Differential expression of the two GH genes during embryonic development of rainbow trout Oncorhynchus mykiss in relation with the IGFs system. Mol. Reprod. Dev. 64, 32–40 (2003)

    Article  CAS  PubMed  Google Scholar 

  236. M.J. Herrero-Turrion, R.E. Rodriguez, A. Velasco, R. Gonzalez-Sarmiento, J. Aijon, J.M. Lara, Growth hormone expression in ontogenic development in gilthead sea bream. Cell Tissue Res. 313, 81–91 (2003)

    Article  CAS  PubMed  Google Scholar 

  237. E.E. Deane, S.P. Kelly, P.M. Collins, N.Y. Woo, Larval development of silver sea bream (Sparus sarba): ontogeny of RNA-DNA ratio, GH, IGF-I, and Na(+)-K(+)-APTase. Mar. Biotechnol. (NY) 5, 79–91 (2003)

    Article  CAS  Google Scholar 

  238. Y. Ozaki, H. Fukada, H. Tanaka, H. Kagawa, H. Ohta, S. Adachi, A. Hara, K. Yamauchi, Expression of growth hormone family and growth hormone receptor during early development in the Japanese eel (Anguilla japonica). Comp. Biochem. Physiol. B: Biochem. Mol. Biol. 145, 27–34 (2006)

    Article  CAS  Google Scholar 

  239. W.S. Li, D. Chen, A.O. Wong, H.R. Lin, Molecular cloning, tissue distribution, and ontogeny of mRNA expression of growth hormone in orange-spotted grouper (Epinephelus coioides). Gen. Comp. Endocrinol. 144, 78–89 (2005)

    Article  CAS  PubMed  Google Scholar 

  240. K.L. Hull, S. Harvey, Growth Hormone and Cancer, in The Molecular and Cellular Pathology of Cancer Progression and Prognosis, ed. by G. Sherbet (Research Signpost, Trivandrum, 2006), pp. 97–138

    Google Scholar 

  241. J.K. Perry, B.S. Emerald, H.C.P.E. Lobie, The oncogenic potential of growth hormone. Growth Horm. IGF Res. 16, 277–289 (2006)

    Article  CAS  PubMed  Google Scholar 

  242. J.B. Engel, G. Keller, A.V. Schally, G.L. Toller, K. Groot, A. Havt, P. Armatis, M. Zarandi, J.L. Varga, G. Hallmos, Inhibition of growth of experimental human endometrial cancer by an antagonist of growth hormone-releasing hormone. J. Clin. Endocrinol. Metab. 90, 3614–3621 (2004)

    Article  CAS  Google Scholar 

  243. L. Zhao, T. Yano, Y. Osuga, S. Nakagawa, H. Oishi, O. Wada-Hiraike, X. Tang, N. Yano, K. Kugu, A.V. Schally, Y. TAketani, Cellular mechanisms of growth inhibition of human endometrial cancer cell line by an antagonist of growth hormone-releasing hormone. Int. J. Oncol. 32, 593–601 (2008)

    PubMed  Google Scholar 

  244. S.T. Bustin, P.J. Jenkins, The growth hormone-insulin-like factor-I axis and colorectal cancer. Trends Mol. Med. 7, 447–454 (2001)

    Article  CAS  PubMed  Google Scholar 

  245. L. Lauriola, N. Maggiano, F.G. Serra, S. Nori, M.L. Trdio, A. Capelli, M. Piantelli, F.O. Ranelletti, Immunohistochemical and in situ hybridization detection of growth-hormone-producing cells in human thymoma. Am. J. Pathol. 151, 55–61 (1997)

    CAS  PubMed  Google Scholar 

  246. J. Kirpensteijn, E.P. Timmermans-Sprang, E. van Garderen, G.R. Rutteman, I.S. Lantinga-van Leeuwen, J.A. Mol, Growth hormone gene expression in canine normal growth plates and spontaneous osteosarcoma. Mol. Cell. Endocrinol. 197, 179–185 (2002)

    Article  CAS  PubMed  Google Scholar 

  247. L.K. Chopin, Veveris-Lowe, A.F. Philipps, A.C. Herrington, Co-expression of GH and GHR isoforms in prostate cancer cell lines. Growth Horm. IGF Res. 12, 126–136 (2002)

    Article  CAS  PubMed  Google Scholar 

  248. Z. Wang, R.M. Luque, R.D. Kineman, V.H. Ray, K.T. Christov, D.D. Lantvit, T. Shirai, S. Hedayat, T.G. Unterman, M.C. Bosland, G.S. Pris, S.M. Swanson, Disruption of growth hormone signaling retards prostate carcinogenesis in the probasin/Tag rat. Endocrinology. 149, 1366–1376 (2008)

    Google Scholar 

  249. L.K. Chopin, A.C. Herington, A potential autocrine pathway for growth hormone releasing hormone (GHRH) and its receptor in human prostate cancer cell lines. Prostate 49, 116–121 (2001)

    Article  CAS  PubMed  Google Scholar 

  250. N. Barabutis, A.V. Schally, Antioxidant activity of growth hormone-releasing hormone antagonists in LNCaP human prostate cancer line. Proc. Natl Acad. Sci. 105, 20470–20475 (2008)

    Article  CAS  PubMed  Google Scholar 

  251. R. Hooghe, S. Merchav, G. Gaidano, F. Naessens, L. Matera, A role for growth hormone and prolactin in leukaemia and lymphoma? Cell. Mol. Life Sci. 54, 1095–1101 (1998)

    Article  CAS  PubMed  Google Scholar 

  252. L.A. Baglia, D. Cruz, J.E. Shaw, Production of immunoreactive forms of growth hormone by the Burkitt tumor serum-free cell line sfRamos. Endocrinology 130, 2446–2454 (1992)

    Article  CAS  PubMed  Google Scholar 

  253. J.T. Farmer, D.A. Weigent, TGF-beta 1 expression in EL4 lymphoma cells overexpressing growth hormone. Cell. Immunol. 240, 22–30 (2006)

    Article  CAS  PubMed  Google Scholar 

  254. R.E. Arnold, D.A. Weigent, The inhibition of superoxide production in EL4 lymphoma cells overexpressing growth hormone. Immunopharmacol. Immunotoxicol. 25, 159–177 (2003)

    Article  CAS  PubMed  Google Scholar 

  255. R.E. Arnold, D.A. Weigent, The inhibition of apoptosis in EL4 lymphoma cells overexpressing growth hormone. Neuroimmunomodulation 11, 149–159 (2004)

    Article  CAS  PubMed  Google Scholar 

  256. D.A. Weigent, R.E. Arnold, Expression of insulin-like growth factor-1 and insulin-like growth factor-1 receptors in EL4 lymphoma cells overexpressing growth hormone. Cell. Immunol. 234, 54–66 (2005)

    Article  CAS  PubMed  Google Scholar 

  257. N. Liu, H.C. Mertani, G. Norstedt, J. Tornell, P.E. Lobie, Mode of the autocrine/paracrine mechanism of growth hormone action. Exp. Cell. Res. 237, 196–206 (1997)

    Google Scholar 

  258. K.K. Kaulsay, H.C. Mertani, K.O. Lee, P.E. Lobie, Autocrine human growth hormone enhancement of human mammary carcinoma cell spreading is Jak2 dependent. Endocrinology 141, 1571–1584 (2000)

    Article  CAS  PubMed  Google Scholar 

  259. K.K. Kaulsay, H.C. Mertani, J. Tornell, G. Morel, K.O. Lee, P.E. Lobie, Autocrine stimulation of human mammary carcinoma cell proliferation by human growth hormone. Exp. Cell Res. 250, 35–50 (1999)

    Article  CAS  PubMed  Google Scholar 

  260. K.K. Kaulsay, T. Zhu, W. Bennett, K. Lee, P.E. Lobie, The effects of autocrine human growth hormone (hGH) on human mammary carcinoma cell behavior are mediated via the hGH receptor. Endocrinology 142, 767–777 (2001)

    Article  CAS  PubMed  Google Scholar 

  261. X. Zhang, B.S. Emerald, S. Mukhina, K.M. Mohankumar, A. Kraemer, A.S. Yap, P.D. Gluckman, K.O. Lee, P.E. Lobie, HOXA1 is required for E-cadherin-dependent anchorage-independent survival of human mammary carcinoma cells. J. Biol. Chem. 281, 6471–6481 (2006)

    Article  CAS  PubMed  Google Scholar 

  262. F. Shafiei, F. Rahnama, L. Pawella, M.D. Mitchell, P.D. Gluckman, P.E. Lobie, DNMT2A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells. Oncogene 27, 2602–2612 (2008)

    Article  CAS  PubMed  Google Scholar 

  263. K.M. Mohankumar, X.Q. Xu, T. Zhu, N. Kannan, L.D. Miller, E.T. Liu, P.D. Gluckman, S. Sukumar, B.S. Emerald, P.E. Lobie, HOXA1-stimuated oncogenicity is mediated by selective upregulation of components of the p44/42 MAP kinase pathway in human mammary carcinoma cells. Oncogene 26, 3998–4008 (2007)

    Article  CAS  PubMed  Google Scholar 

  264. K.M. Mohankumar, J.K. Perry, N. Kannan, K. Kohno, P.D. Gluckman, B.S. Emerald, P.E. Lobie, Transcriptional activation of signal transducer and activator of transcription (STAT)3 and STAT5B partially mediate homeobox A1-stimulated oncogenic transformation of the immortalized human mammary epithelial cell. Endocrinology 149, 2219–2229 (2008)

    Article  CAS  PubMed  Google Scholar 

  265. X. Zhang, T. Zhu, Y. Chen, H.C. Mertani, K.O. Lee, P.E. Lobie, Human growth hormone-regulated HOXA1 is a human mammary epithelial oncogene. J. Biol. Chem. 278, 7580–7590 (2003)

    Article  CAS  PubMed  Google Scholar 

  266. T. Zhu, B. Starling-Emerald, X. Zhang, K.O. Lee, P.D. Gluckman, H.C. Mertani, P.E. Lobie, Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormone. Cancer Res. 65, 317–324 (2005)

    CAS  PubMed  Google Scholar 

  267. Z. Zhu, S. Mukhina, T. Zhu, H.C. Mertani, K.O. Lee, P.E. Lobie, p44/42 MAP kinase-dependent regulation of catalase by autocrine human growth hormone protects human mammary carcinoma cells from oxidative stress-induced apoptosis. Oncogene 24, 3774–3785 (2005)

    Article  CAS  PubMed  Google Scholar 

  268. C.M. Vouyovitch, L. Vidal, S. Borges, M. Raccurt, C. Arnould, J. Chiesa, P.E. Lobie, J. Lachuer, H.C. Mertani, Proteomic analysis of autocrine/paracrine effects of human growth hormone in human mammary carcinoma. Adv. Exp. Med. Biol. 617, 493–500 (2008)

    Article  PubMed  CAS  Google Scholar 

  269. H.C. Mertani, T. Zhu, E.L. Goh, K.O. Lee, G. Morel, P.E. Lobie, Autocrine human growth hormone (hGH) regulation of human mammary carcinoma cell gene expression. Identification of CHOP as a mediator of hGH-stimulated human mammary carcinoma cell survival. J. Biol. Chem. 279, 21464–21475 (2001)

    Article  Google Scholar 

  270. R. Graichen, D.Z. Liu, Y. Sun, K.O. Lee, P.E. Lobie, Autocrine human growth hormone inhibits placental transforming growth factor-β gene transcription to prevent apoptosis and allow cell cycle progression of human mammary carcinoma cells. J. Biol. Chem. 277, 26662–26672 (2002)

    Article  CAS  PubMed  Google Scholar 

  271. S.E. Brunet-Dunand, C. Vouyovitch, S. Araneda, V. Pandey, L.J.P. Vidal, C. Print, H.C. Mertani, P.E. Lobie, J.K. Perry, Autocrine human growth hormone promotes tumor angiogenesis in mammary carcinoma. Endocrinology 150, 1341–1352 (2009)

    Article  CAS  PubMed  Google Scholar 

  272. X.Q. Xu, B. Starling Emerald, E.L.K. Goh, N. Kannan, L.D. Miller, P.D. Gluckman, E.T. Liu, P.E. Lobie, Gene expression profiling to identify oncogenic determinants of autocrine human growth hormone in human mammary carcinoma. J. Biol. Chem. 280, 23987–24003 (2005)

    Article  CAS  PubMed  Google Scholar 

  273. J.K. Perry, N. Kannan, P.M. Grandison, M.D. Mitchell, P.E. Lobie, Are trefoil factors oncogenic? Trends Endocrinol. Metab. 19, 74–81 (2008)

    CAS  PubMed  Google Scholar 

  274. J.K. Perry, K.M. Mohankumar, B.S. Emerald, H.C. Mertani, P.E. Lobie, The contribution of growth hormone to mammary neoplasia. J. Mammary Gland Biol. Neoplasia 13, 131–145 (2008)

    Article  PubMed  Google Scholar 

  275. S. Pyronnet, C. Bousquet, S. Najib, R. Azar, H. Laklai, C. Susini, Antitumor effects of somatostatin. Mol. Cell. Endocrinol. 286, 230–237 (2008)

    Article  CAS  PubMed  Google Scholar 

  276. A.V. Schally, J.L. Varga, Antagonistic analogs of growth hormone-releasing hormone: new potential antitumor agents. Trends Endocrinol. Metab. 10, 383–391 (1999)

    Article  CAS  PubMed  Google Scholar 

  277. M.J. van den Eijnden, G.J. Strous, Autocrine growth hormone: effects on growth hormone receptor trafficking and signaling. Mol. Endocrinol. 21, 2832–2846 (2007)

    Article  PubMed  CAS  Google Scholar 

  278. E. Tallet, V. Rouet, J.B. Jomain, P.A. Kelly, S. Bernichtein, V. Goffin, Rational design of competitive prolactin/growth hormone receptor antagonists. J. Mammary Gland Biol. Neoplasia 13, 105–117 (2008)

    Article  PubMed  Google Scholar 

  279. R. Dehari, Y. Nakamura, N. Okamoto, H. Nakayama, Increased nuclear expression of growth hormone receptor in uterine cervical neoplasms of women under 40 years old. Tohoku J. Exp. Med. 216, 165–172 (2008)

    Article  CAS  PubMed  Google Scholar 

  280. B.L. Conway-Campbell, J.W. Wooh, A.J. Brooks, D. Gordon, R.J. Brown, A.M. Lichanska, H.S. Chin, C.L. Barton, G.M. Boyle, P.G. Parsons, D.A. Jans, M.J. Waters, Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis. Proc. Natl Acad. Sci. USA 104, 13331–13336 (2007)

    Article  CAS  PubMed  Google Scholar 

  281. A.J. Brooks, J.W. Wooh, K.A. Tunny, M.J. Waters, Growth hormone receptor; mechanism of action. Int. J. Biochem. Cell Biol. 40, 1984–1989 (2008)

    Article  CAS  PubMed  Google Scholar 

  282. K.L. Hull, M. Luna, S. Harvey, C. Aramburo, Growth Hormone: A Pituitary and Extrapituitary Chameleon During Development, in Functional Avian Endocrinology, ed. by A. Dawson, P.J. Sharp (Narosa Publishing House, New Delhi, 2005), pp. 389–400

    Google Scholar 

  283. B.D. Anawalt, G.R. Merriam, Neuroendocrine aging in men. Andropause and somatopause. Endocrinol. Metab. Clin. North Am. 30, 647–669 (2001)

    Article  CAS  PubMed  Google Scholar 

  284. C.J. Rosen, Growth hormone and aging. Endocrine 12, 197–201 (2000)

    Article  CAS  PubMed  Google Scholar 

  285. A.A. Toogood, S.M. Shalet, Conflicts with the somatopause. Growth Horm. IGF Res. 8, 47–54 (1998)

    Article  PubMed  Google Scholar 

  286. D.A. Weigent, J.B. Baxter, W.E. Wear, L.R. Smith, K.L. Bost, J.E. Blalock, Production of immunoreactive growth hormone by mononuclear leukocytes. FASEB J. 2, 2812–2818 (1988)

    CAS  PubMed  Google Scholar 

  287. Martinez-Moreno, M. Luna, C. Aramburo, Growth hormone secretion in chicken testicular cell culture. Abstract P115, Proceedings of the 23rd Conference of European Comparative Endocrinologists, Manchester, UK, p. 127 (2006)

  288. D.A. Weigent, J.E. Blalock, Expression of growth hormone by lymphocytes. Int. Rev. Immunol. 4, 193–211 (1989)

    Article  CAS  PubMed  Google Scholar 

  289. W.M. Rohn, D.A. Weigent, Cloning and nucleotide sequencing of rat lymphocyte growth hormone cDNA. Neuroimmunomodulation 2, 108–114 (1995)

    Article  CAS  PubMed  Google Scholar 

  290. C.L. Render, K.L. Hull, S. Harvey, Neural expression of the pituitary GH gene. J. Endocrinol. 147, 413–422 (1995)

    Article  CAS  PubMed  Google Scholar 

  291. C.L. Render, K.L. Hull, S. Harvey, Expression of the growth hormone gene in immune tissues. Endocrine 3, 729–735 (1995)

    Article  CAS  PubMed  Google Scholar 

  292. P.J. Selman, J.A. Mol, G.R. Rutteman, E. van Garderen, A. Rijnberk, Progestin-induced growth hormone excess in the dog originates in the mammary gland. Endocrinology 134, 287–292 (1994)

    Article  CAS  PubMed  Google Scholar 

  293. Y.M. Bohlooly, B. Olsson, C.E. Bruder, D. Linden, K. Sjorgren, M. Bjursell, E. Egecioglu, L. Svensson, P. Brodin, J.C. Waterton, O.G. Isaksson, F. Sundler, B. Ahren, C. Ohlsson, J. Oscarsson, J. Tornell, Growth hormone expression in the central nervous system results in hyperphagia-induced obesity associated with insulin resistance and hyslipidemia. Diabetes 54, 51–62 (2005)

    Article  CAS  PubMed  Google Scholar 

  294. B. Olsson, Y.M. Bohlooly, S.M. Fitzgerald, F. Frick, A. Ljungberg, B. Ahren, J. Tornell, G. Bergstrom, J. Oscarsson, Bovine growth hormone transgenic mice are resistant to diet-induced obesity but develop hyperphagia, dyslipidemia, and diabetes on a high-fat diet. Endocrinology 146, 920–930 (2005)

    Article  CAS  PubMed  Google Scholar 

  295. D.E. Berryman, E.O. List, K.T. Coshcigano, K. Behar, J.K. Kim, J.J. Kopchick, Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm. IGF Res. 14, 309–318 (2004)

    Article  CAS  PubMed  Google Scholar 

  296. P.G. Hollingshead, L. Martin, S.L. Pitts, T.A. Stewart, A dominant phenocopy of hypopituitarism in transgenic mice resulting from central nervous system synthesis of human growth hormone. Endocrinology 125, 1556–1564 (1989)

    Article  CAS  PubMed  Google Scholar 

  297. D.M. Flavell, T. Wells, S.E. Wells, D.F. Carmignac, G.B. Thomas, I.C.A.F. Robinson, Dominant dwarfism in transgenic rats by targeting human growth hormone (GH) expression to hypothalamic GH-releasing factor neurons. EMBO J. 15, 3871–3879 (1996)

    CAS  PubMed  Google Scholar 

  298. T. Wells, D.M. Flavell, S.E. Wells, D.F. Carmignac, I.C.A.P. Robinson, Effects of growth hormone secretagogues in the transgenic growth-retarded (Tgr) rat. Endocrinology 138, 580–587 (1997)

    Article  CAS  PubMed  Google Scholar 

  299. E. Pellegrini, D.F. Carmignac, M.T. Bluet-Pajot, F. Mounier, P. Bennett, J. Eqelbaum, I.C.A.F. Robinson, Intrahypothalamic growth hormone feedback: from dwarfism to acromegaly in the rat. Endocrinology 138, 4543–4551 (1997)

    Article  CAS  PubMed  Google Scholar 

  300. S.E. Wells, D.M. Flavell, G.W. Bisset, P.A. Houston, H. Christian, K.M. Fairhall, I.C.A.F. Robinson, Transgenesis and neuroendocrine physiology: a transgenic rat model expression growth hormone in vasopressin neurons. J. Physiol. 55, 323–336 (2003)

    Article  Google Scholar 

  301. D. Le Roith, Clinical relevance of systemic and local IGF-1: lessons from animal models. Pediatr. Endocrinol. Rev. 5(supp), 12739–12743 (2008)

    Google Scholar 

  302. S. Yakar, Y. Wu, J. Setser, C.J. Rosen, The role of circulating IGF-1: lessons from human and animal models. Endocrine 19, 239–248 (2002)

    Article  CAS  PubMed  Google Scholar 

  303. J. Bernichtein, P. Touraine, V. Goffin, New concepts in prolactin biology. J. Endocrinol. 206, 1–11 (2010)

    Article  CAS  PubMed  Google Scholar 

  304. K. Foitzik, E.A. Langan, R. Paus, Prolactin and the skin: a dermatological perspective on an ancient pleiotropic peptide hormone. J. Invest. Dermatol. 129, 1071–1087 (2009)

    Article  CAS  PubMed  Google Scholar 

  305. N. Ben-Jonathan, K. Liby, M. McFarland, M. Zinger, Prolactin as an autocrine/paracrine growth factor in human cancer. Trends Endocrinol. Metab. 13, 245–250 (2002)

    Article  CAS  PubMed  Google Scholar 

  306. D. Shoback, J.L. Funk, Ectopic Hormone and Receptor Syndromes, in Greenspan’s Basic & Clinical Endocrinology, ed. by F.S. Greenspan, D.G. Gardner (Lange Medical Books, McGraw Hill, New York, 2001), pp. 778–791

    Google Scholar 

  307. P.C. Kohler, D.L. Trump, Clinical science review: ectopic hormone syndromes. Cancer Invest. 4, 543–554 (1986)

    Article  CAS  PubMed  Google Scholar 

  308. M. Terzolo, G. Reimondo, A. Ali, S. Bovio, F. Daffara, P. Paccotti, A. Angeli, Ectopic ACTH syndrome. Ann. Oncol. 12, S83–S87 (2001)

    Article  PubMed  Google Scholar 

  309. R.C. Osthus, B. Karim, J.E. Prescott, B.D. Smith, M. McDevitt, D.L. Huso, C.V. Dang, The Myc target gene JP01/CDCA7 is frequently overexpressed in human tumors and has limited transforming activity in vivo. Cancer Res. 65, 5620–5627 (2005)

    Article  CAS  PubMed  Google Scholar 

  310. N.R. Smalheiser, Proteins in unexpected locations. Mol. Biol. Cell 7, 1003–1014 (1996)

    CAS  PubMed  Google Scholar 

  311. S. Harvey, Y. Azumaya, K.L. Hull, Pituitary and extrapituitary growth hormone: Pit-1 dependence? Can. J. Physiol. Pharmacol. 78, 1013–1028 (2000)

    Article  CAS  PubMed  Google Scholar 

  312. N. Hattori, Expression regulation and biological actions of growth hormone (GH) and ghrelin in the immune system. Growth Horm. IGF Res. 19, 187–197 (2009)

    Article  CAS  PubMed  Google Scholar 

  313. M. Ballesteros, K.C. Leung, R.J. Ross, T.P. Lismaa, K.K. Ho, Distribution and abundance of messenger ribonucleic acid for growth hormone receptor isoforms in human tissue. J. Clin. Endocrinol. Metab. 85, 2865–2871 (2000)

    Article  CAS  PubMed  Google Scholar 

  314. H.C. Mertani, G. Morel, In situ gene expression of growth hormone (GH) receptor and GH binding protein in adult male rat tissues. Mol. Cell. Endocrinol. 109, 47–61 (1995)

    Article  CAS  PubMed  Google Scholar 

  315. T.S. Tiong, A.C. Herington, Tissue distribution, characterization, and regulation of messenger ribonucleic acid for growth hormone receptor and serum binding protein in the rat. Endocrinology 129, 1628–1634 (1991)

    Article  CAS  PubMed  Google Scholar 

  316. C.J. Strasburger, M.T. Dattani, New growth hormone assays: potential benefits. Acta Paediatr. Suppl. 423, 5–11 (1997)

    CAS  PubMed  Google Scholar 

  317. E.A. Chaler, P. Travaglino, S. Pagani, E. Bozzola, R. Marino, E. Berensztein, M. Maceiras, M. Tauber, M.A. Rivarola, A. Belgorosky, M. Bozzola, Dose dependency of the serum bio/immuno GH ratio in children during pharmacological secretion tests. J. Endocrinol. Invest. 29, 109–114 (2006)

    CAS  PubMed  Google Scholar 

  318. M.E. Geffner, The growth without growth hormone syndrome. Endocrinol. Metab. Clin. North Am. 25, 649–663 (1996)

    Article  CAS  PubMed  Google Scholar 

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Supported by NSERC of Canada.

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  1. Department of Physiology, University of Alberta, 7-41 Medical Sciences Building, Edmonton, AB, T6G 2H7, Canada

    S. Harvey

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Harvey, S. Extrapituitary growth hormone. Endocr 38, 335–359 (2010). https://doi.org/10.1007/s12020-010-9403-8

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