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Ameliorating Effects of Combined Curcumin and Desferrioxamine on 6-OHDA-Induced Rat Mode of Parkinson’s Disease

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Abstract

The catecholaminergic neurotoxin 6-hydroxydopamine has been widely used to mimic the lesions in dopaminergic neurons to develop Parkinson’s disease. The present study was aimed to evaluate the combined treatment with Curcumin and desferrioxamine (DFO) on 6-OHDA- induced neurotoxicity in the striatum of rats. Rat models with 6-OHDA-induced Parkinson’s disease were treated with curcumin, DFO, or both and the effect of different treatments on dopamine level was examined. Moreover, the effect of different treatments on the levels of PCC, SOD, and GSH was also assessed to elucidate the underlying mechanisms of the neuroprotective effects of combined treatment of curcumin and DFO.

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Authors and Affiliations

  1. First Division of Neurology Department, Shaanxi Provincial People’s Hospital, Xian, 710068, Shanxi, China

    Hua Lv, Jun Liu, Li Wang, Hong Zhang, Shuqi Yu, Zhiwei Li, Feng Jiang, Yu Niu, Jie Yuan, Xiaoli Cui & Wenxiu Wang

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  1. Hua Lv
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  2. Jun Liu
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  3. Li Wang
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  4. Hong Zhang
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  5. Shuqi Yu
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  6. Zhiwei Li
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  7. Feng Jiang
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  8. Yu Niu
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  9. Jie Yuan
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  10. Xiaoli Cui
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  11. Wenxiu Wang
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Correspondence to Hua Lv.

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Lv, H., Liu, J., Wang, L. et al. Ameliorating Effects of Combined Curcumin and Desferrioxamine on 6-OHDA-Induced Rat Mode of Parkinson’s Disease. Cell Biochem Biophys 70, 1433–1438 (2014). https://doi.org/10.1007/s12013-014-0077-3

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  • DOI: https://doi.org/10.1007/s12013-014-0077-3

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