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Parental Lead Exposure Promotes Neurobehavioral Disorders and Hepatic Dysfunction in Mouse Offspring

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Abstract

Lead (Pb) induces neurotoxicity in both children and adults. Children are more vulnerable to Pb toxicity than adults. Little is known about the effects of Pb on the mental health of the children who are prenatally exposed. Therefore, we designed an animal experiment to compare the adverse effects of Pb on neurobehavioral and hepatic functions between Pb-exposed (Pb mice) and parental Pb-exposed (P-Pb mice) group mice. Mice were treated with Pb-acetate (10 mg/kg bodyweight/day) via drinking water. Male mice from unexposed parents treated with Pb for 90 days were defined as Pb mice, whereas male mice from Pb-exposed parents treated with Pb for further 90 days were defined as P-Pb mice. Anxiety-like behavior and spatial memory and learning were assessed by elevated plus maze and Morris water maze. Serum hepatic enzyme activities and butyrylcholinesterase activity were measured by an analyzer. P-Pb mice displayed increased anxiety-like behavior and memory and learning impairments compared to Pb mice. BChE activity was significantly decreased in P-Pb mice compared to Pb mice. Pb levels in the brains of P-Pb mice were significantly higher than those of Pb mice. The activities of serum hepatic enzymes of P-Pb mice were also higher than those of Pb mice. Additionally, histopathology data revealed that hepatic tissue injury was more pronounced in P-Pb mice than in Pb mice. Thus, the results suggest that persistent exposure to Pb from fetus to adult causes more severe neurobehavioral changes and hepatic toxicities than adult exposure only.

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Data Availability

The dataset supporting the findings of the study is available from the corresponding author on request.

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Funding

This research work was supported by the grant (Grant No – 1181/5/52/RABI/BINGAN-20/19-20) from the University of Rajshahi, Bangladesh.

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  1. Hasan Ul Banna and Adiba Anjum contributed equally to this work.

Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh

    Hasan Ul Banna, Adiba Anjum, Sheta Biswas, Victor Mondal, Abu Eabrahim Siddique, Farjana Nikkon, Kazi Abdus Salam, Khaled Hossain & Zahangir Alam Saud

  2. Department of Biochemistry and Molecular Biology, Mawlana Bhashani Science and Technology University, Tangail, 1902, Bangladesh

    Adiba Anjum

  3. Department of Biochemistry and Molecular Biology, Noakhali Science and Technology University, Noakhali, 3814, Bangladesh

    Sheta Biswas

  4. Department of Genetic Engineering and Biotechnology, University of Rajshahi, Rajshahi, 6205, Bangladesh

    Apurba Kumar Roy

  5. Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC, USA

    Azizul Haque

  6. Laboratory of Molecular Nutrition and Toxicology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, 770-8514, Japan

    Seiichiro Himeno

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  1. Hasan Ul Banna
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Correspondence to Zahangir Alam Saud.

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Institutional ethical approval (No: 127/320/IAMEBBC/IBSc) was received for the animal experiment from the Institute of Biological Sciences, University of Rajshahi, Bangladesh.

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Banna, H.U., Anjum, A., Biswas, S. et al. Parental Lead Exposure Promotes Neurobehavioral Disorders and Hepatic Dysfunction in Mouse Offspring. Biol Trace Elem Res 200, 1171–1180 (2022). https://doi.org/10.1007/s12011-021-02709-y

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