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Combined Effects of Muscular Dystrophy, Ecological Stress, and Selenium on Blood Antioxidant Status in Broiler Chickens

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Abstract

The results obtained in this study demonstrated that experimentally induced alimentary muscular dystrophy (MD) in Cobb 500 broiler chickens resulted in increased plasma concentrations of malondialdehyde (MDA), deviations in activities of erythrocyte antioxidant enzymes Cu,Zn-SOD (decrease), and CAT (increase) as well as reduction in plasma concentrations of trace elements Cu, Zn, and Se in affected birds. These data evidenced the presence of oxidative stress in birds with MD, reared both under conditions of ecological comfort and ecological stress. The increased MDA and САТ levels and the reduced Cu,Zn-SOD, Cu, Zn, and Se concentrations in healthy chickens reared under unfavorable microclimatic conditions such as higher air temperature and humidity, higher ammonia concentrations, and lower light intensity were indicative about an induced ecological stress. After the 10-day oral treatment with a selenium-containing preparation, the levels of MDA, Cu,Zn-SOD, CAT, Cu, Zn, and Se attained their normal values in chickens with MD, reared under ecologically comfortable conditions. According to our results, ecological stress was shown to exert independently a significant adverse effect upon the levels of the studied parameters and possibly to be a cause for their slower and not complete normalization despite the selenium therapy in experimental broiler chickens.

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Authors and Affiliations

  1. Department of Pharmacology, Physiology of Animals and Physiologic Chemistry, Faculty of Veterinary Medicine, Trakia University, Student’s Campus, 6000, Stara Zagora, Bulgaria

    Nedyalka V. Georgieva

  2. Department of Internal Diseases and Clinical Toxicology, Faculty of Veterinary Medicine, Trakia University, 6000, Stara Zagora, Bulgaria

    Krasimir Stoyanchev

  3. Department of Animal Hygiene, Ethology and Animal Protection, Faculty of Veterinary Medicine, Trakia University, 6000, Stara Zagora, Bulgaria

    Nadia Bozakova

  4. Department of Animal Husbandry, Faculty of Veterinary Medicine, Trakia University, 6000, Stara Zagora, Bulgaria

    Ivanka Jotova

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  1. Nedyalka V. Georgieva
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  2. Krasimir Stoyanchev
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  3. Nadia Bozakova
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  4. Ivanka Jotova
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Correspondence to Nedyalka V. Georgieva.

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Georgieva, N.V., Stoyanchev, K., Bozakova, N. et al. Combined Effects of Muscular Dystrophy, Ecological Stress, and Selenium on Blood Antioxidant Status in Broiler Chickens. Biol Trace Elem Res 142, 532–545 (2011). https://doi.org/10.1007/s12011-010-8782-2

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  • DOI: https://doi.org/10.1007/s12011-010-8782-2

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