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Effects of Copper Sources and Levels on Lipid Profiles, Immune Parameters, Antioxidant Defenses, and Trace Element Residues in Broilers

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Abstract

The study was conducted to investigate the effects of copper sources and levels on lipid profiles, immune parameters, antioxidant defenses, and trace element contents of meat and liver in Arbor Acres broilers. A total of 504 male broilers were randomly divided into 7 groups with 6 replicates per group and 12 broilers per replicate. The experiment was used in a 3 × 2 + 1 factorial experiment design; broilers in the control group were fed a basal diet, and broilers in the other six groups were fed basal diets supplemented with 3 sources (copper sulfate, tribasic copper chloride, and copper methionate) and 2 levels (10 and 20 mg/kg). The results showed that the levels of cholesterol and low-density lipoprotein cholesterol in broilers were significantly decreased with the increase of dietary copper level (P < 0.05). Serum IL-6 and IgA contents, ceruloplasmin and GSH-Px activities, and liver copper contents of broilers increased significantly with dietary copper levels (P < 0.05). Compared with the control group, dietary copper supplementation significantly decreased serum cholesterol (P < 0.05) and significantly increased serum IL-6, ceruloplasmin, SOD, GSH-Px, and liver copper (P < 0.05). Dietary supplementation of basic copper chloride and copper methionate significantly decreased low-density lipoprotein cholesterol content and liver iron content (P < 0.05). In conclusion, dietary copper supplementation can effectively reduce serum cholesterol content and improve immune and antioxidant functions in broilers. Adding 20 mg/kg copper to broiler diet can increase the copper content in the liver, but it will not affect the copper content in the chicken.

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Funding

The funding for this study was from High-level Talents Introduction Project of Anhui Institute of Science and Technology (DKYJ201701), Natural Science Foundation of Anhui Province of China (1708085QC74), Chuzhou Science and Technology Project (2018ZN014), and the fund of Natural Science Foundation in Higher Education of Anhui, China (KJ2018A0535).

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Authors and Affiliations

  1. College of Animal Science, Anhui Science and Technology University, 1501 Huangshan Avenue, Bengbu, 233100, Anhui, China

    Xuezhuang Wu & Lixin Wang

  2. College of Agronomy, Liaocheng University, 1 Hunan Road, Liaocheng, 252059, Shandong, China

    Mingxia Zhu

  3. Public Health Research Institute, New Jersey Medical School, Rutgers Biomedical and Health Sciences, Rutgers-The State University of New Jersey, 225 Warren Street, Newark, NJ, 07103, USA

    Qingkui Jiang

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  1. Xuezhuang Wu
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Correspondence to Mingxia Zhu or Qingkui Jiang.

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Wu, X., Zhu, M., Jiang, Q. et al. Effects of Copper Sources and Levels on Lipid Profiles, Immune Parameters, Antioxidant Defenses, and Trace Element Residues in Broilers. Biol Trace Elem Res 194, 251–258 (2020). https://doi.org/10.1007/s12011-019-01753-z

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