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Chondrosarcoma of Bone: Lessons From 46 Operated Cases in a Single Institution

  • Symposium: Highlights of the ISOLS/MSTS 2009 Meeting
  • Published:
Clinical Orthopaedics and Related Research®

Abstract

Background

Bone chondrosarcomas are rare malignant tumors that have variable biologic behavior, and their treatment is controversial. For low-grade tumors, there is no consensus on whether intralesional en bloc resections are the best treatment.

Questions/purposes

We therefore compared patients with Grade 1 and Grade 2 primary central chondrosarcomas to (1) determine difference in survival and (2) local recurrence rates; and (3) determine any association of histological grade with some clinical and demographic characteristics.

Methods

We retrospectively reviewed 46 patients with grade 1 and 2 chondrosarcomas. There were 25 men and 21 women with a mean age of 43 years (range, 17–79 years). Minimum followup was 32 months (mean, 99 months; range, 32–312 months) for the patients who remained alive in the end of the study. Twenty-three of the tumors were intracompartmental (Enneking A); of these, 19 were Grade 1 and 4 were Grade 2. Twenty-three tumors were extracompartmental (Enneking B); of these, 4 were Grade 1 and 19 were Grade 2. Twenty-five patients underwent intralesional resection, 18 had wide resection, and three had amputations.

Results

The overall survival rate was 94% and the disease-free survival rate was 90%. Among the 23 Grade 1 tumors, we observed six local recurrences and none of these patients died; among the 23 Grade 2 tumors, 10 recurred and two patients died. Local recurrence negatively influenced survival.

Conclusions

For lesions with radiographic characteristics of intracompartmental Grade 1 chondrosarcoma, we believe intralesional resection followed by electrocauterization and cement is the best treatment. When the imaging suggests aggressive (Grade 2 or 3) chondrosarcoma, then wide resection is promptly indicated.

Level of Evidence

Level IV, case series. See Guidelines for Authors for a complete description of levels of evidence.

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Acknowledgments

We thank Tomaz Puga Leivas for his contribution in the statistical analysis of this study.

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Authors and Affiliations

  1. Department of Orthopaedics, University of São Paulo, Rua Ovídio Pires de Campos, 333 – Cerqueira César, São Paulo, CEP 05403-010, Brazil

    Olavo Pires de Camargo MD, PhD

  2. Orthopaedic Oncology Group, University of São Paulo, São Paulo, Brazil

    André Mathias Baptista MD

  3. University of São Paulo Medical School, São Paulo, Brazil

    Marcelo Junqueira Atanásio & Daniel Reis Waisberg

Authors
  1. Olavo Pires de Camargo MD, PhD
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  2. André Mathias Baptista MD
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  3. Marcelo Junqueira Atanásio
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  4. Daniel Reis Waisberg
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Corresponding author

Correspondence to Olavo Pires de Camargo MD, PhD.

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Each author certifies that he or she has no commercial association (eg, consultancies, stock of ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article.

Each author certifies that his or her institution has approved the human protocol for this investigation, and that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained.

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de Camargo, O.P., Baptista, A.M., Atanásio, M.J. et al. Chondrosarcoma of Bone: Lessons From 46 Operated Cases in a Single Institution. Clin Orthop Relat Res 468, 2969–2975 (2010). https://doi.org/10.1007/s11999-010-1368-7

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  • DOI: https://doi.org/10.1007/s11999-010-1368-7

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