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Metastatic Potential of Grade I Chondrosarcoma of Bone: Results of a Multi-institutional Study

  • Bone and Soft Tissue Sarcomas
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Little is known about the metastatic potential of low-grade chondrosarcoma. This study was designed to evaluate the rate of metastasis to identify possible risk factors.

Methods

The files of 225 patients with newly diagnosed, grade I chondrosarcoma of bone treated between 1975 and 2012 were retrospectively analyzed. Median follow-up was 80 months for survivors (range 24–445 months). Nonparametric analyses were performed with the Mann–Whitney U test. Survival curves were calculated with the Kaplan–Meier method and compared with the log-rank test.

Results

Fourteen patients developed metastases after a median of 49 months. Metastasis-free survival probability (MFS) was 95 % at 5 years and 92 % at 10 years. Post-metastasis survival probability amounted to 27 % after 5 years. Tumor size at diagnosis (P = 0.698) and surgical margin width (P = 0.514) had no influence on MFS. Patients who developed local recurrences had a significantly lower 10-year MFS than patients without recurrences (69 % vs. 99 %, P < 0.001). Patients with grade I recurrences had a significantly poorer MFS than patients without recurrences (P = 0.013) but a significantly higher MFS than patients with grade II recurrences (P = 0.006). Patients with thoracic wall tumors had a significantly lower 10-year MFS of 66 % compared with patients with tumors of the upper (100 %, P < 0.001) and lower extremity (93 %, P = 0.033).

Conclusions

The biological behavior of low-grade chondrosarcoma appears to be more consistent with the WHO definition of rarely metastasizing bone tumors, rather than the one of locally aggressive neoplasms. Thoracic wall tumors and the development of local recurrences were associated with a higher metastasis rate in this study.

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Disclosure

The authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of General Orthopedics and Tumor Orthopedics, Münster University Hospital, Münster, Germany

    Dimosthenis Andreou MD, Georg Gosheger MD, Jendrik Hardes MD & Arne Streitbürger MD

  2. Department of Orthopedic Surgery, Medical University of Graz, Graz, Austria

    Magdalena M. Gilg MD & Andreas Leithner MD

  3. Department of Pathology, Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Emil von Behring, Berlin, Germany

    Mathias Werner MD

  4. Department of Hematology, Oncology and Palliative Care, Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Bad Saarow, Bad Saarow, Germany

    Daniel Pink MD

  5. Department of Orthopedic Oncology, Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Berlin-Buch, Berlin, Germany

    Per-Ulf Tunn MD

Authors
  1. Dimosthenis Andreou MD
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  2. Magdalena M. Gilg MD
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  3. Georg Gosheger MD
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  4. Mathias Werner MD
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  5. Jendrik Hardes MD
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  6. Daniel Pink MD
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  7. Andreas Leithner MD
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  8. Per-Ulf Tunn MD
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  9. Arne Streitbürger MD
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Corresponding author

Correspondence to Dimosthenis Andreou MD.

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Andreou, D., Gilg, M.M., Gosheger, G. et al. Metastatic Potential of Grade I Chondrosarcoma of Bone: Results of a Multi-institutional Study. Ann Surg Oncol 23, 120–125 (2016). https://doi.org/10.1245/s10434-015-4852-1

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  • DOI: https://doi.org/10.1245/s10434-015-4852-1

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