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Recent Advances in Citric Acid Bio-production and Recovery

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Abstract

Citric acid consumption is escalating gradually, witnessing high annual growth rate due to more and more advanced applications coming to light. The present review discusses different aspects of fermentation and effects of various environmental parameters and deals with the potential ways to increase the yield of citric acid to meet the ever-increasing demands of this commercially important organic acid. Different techniques for the hyperproduction of citric acid are continuously being studied from the past few decades and still there is a gap, and hence, there is an obvious need to consider new pragmatic ways to achieve industrially feasible and environmentally sustainable bio-production of citric acid. The utilization of inexpensive agro-industrial wastes and their by-products through solid-state fermentation by existing and genetically engineered strains is a potential route. This review also deals with downstream processing considering the classical and advanced approaches, which also need significant improvement. In situ product recovery method which leads to improved yields and productivity can be further optimized for large-scale production and recovery of citric acid.

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Abbreviations

CA:

Citric acid

DP:

Degree of polymerization

GRAS:

Generally recognized as safe

HMF:

Hydroxyl-methyl furfural

ISPR:

In situ product recovery

POC:

Poly(1,8-octanediol-co-citric acid)

SF:

Surface fermentation

SMB:

Simulated moving bed

SmF:

Submerged fermentation

SSF:

Solid-state fermentation

TIC:

Template-induced crystallization

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Acknowledgements

The authors are sincerely thankful to the Natural Sciences and Engineering Research Council of Canada (Discovery Grant 355254, Canada Research Chair), FQRNT (ENC 125216) and MAPAQ (No. 809051) for financial support. The views or opinions expressed in this article are those of the authors.

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  1. INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec, Canada, G1K 9A9

    Gurpreet Singh Dhillon, Satinder Kaur Brar & Rajeshwar Dayal Tyagi

  2. Institut de Recherche et de Développement en Agroenvironnement Inc. (IRDA), 2700 rue Einstein, Québec, Québec, Canada, G1P 3W8

    Mausam Verma

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  1. Gurpreet Singh Dhillon
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Correspondence to Satinder Kaur Brar.

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Singh Dhillon, G., Kaur Brar, S., Verma, M. et al. Recent Advances in Citric Acid Bio-production and Recovery. Food Bioprocess Technol 4, 505–529 (2011). https://doi.org/10.1007/s11947-010-0399-0

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