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Application of Metabolomics to Osteoarthritis: from Basic Science to the Clinical Approach

  • Osteoarthritis (M Goldring, Section Editor)
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Abstract

Purpose of the Review

Osteoarthritis (OA) is a multifactorial and progressive disease affecting whole synovial joint. The extract pathogenic mechanisms and diagnostic biomarkers of OA remain unclear. In this article, we review the studies related to metabolomics of OA, discuss the biomarkers as a tool for early OA diagnosis. Furthermore, we examine the major studies on the application of metabolomics methodology in the complex context of OA and create a bridge from findings in basic science to their clinical utility.

Recent Findings

Recently, the tissue metabolomics signature permits a view into transitional phases between the healthy and OA joint. Both nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry-based metabolomics approaches have been used to interrogate the metabolic alterations that may indicate the complex progression of OA. Specifically, studies on alterations pertaining to lipids, glucose, and amino acid metabolism have aided in the understanding of the complex pathogenesis of OA.

Summary

The discovery of identified metabolites could be important for diagnosis and staging of OA, as well as for the assessment of efficacy of new drugs.

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Authors and Affiliations

  1. Institute of Health and Biomedical Innovation, Faculty of Science and Engineering, Queensland University of Technology, Kelvin Grove Campus, Brisbane, QLD, 4059, Australia

    Salah Ali A. Showiheen, Antonia RuJia Sun, Xiaoxin Wu, Ross Crawford, Yin Xiao, R. Mark Wellard & Indira Prasadam

  2. Department of Orthopaedic Surgery, Second Xiangya Hospital, Central South University, Changsha, China

    Xiaoxin Wu

  3. Orthopedic Department, The Prince Charles Hospital, Brisbane, QLD, Australia

    Ross Crawford

  4. Australia–China Centre for Tissue Engineering and Regenerative Medicine, Queensland University of Technology, Brisbane, QLD, Australia

    Yin Xiao

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  1. Salah Ali A. Showiheen
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Correspondence to Indira Prasadam.

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Showiheen, S.A.A., Sun, A.R., Wu, X. et al. Application of Metabolomics to Osteoarthritis: from Basic Science to the Clinical Approach. Curr Rheumatol Rep 21, 26 (2019). https://doi.org/10.1007/s11926-019-0827-8

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