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The Role of Anti-angiogenesis in Non-small-cell Lung Cancer: an Update

  • Lung Cancer (T Mekhail, Section Editor)
  • Published:
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Abstract

Recognition of the vascular endothelial growth factor (VEGF) pathway as a key mediator of angiogenesis has led to the clinical study of several VEGF and VEGF receptor (VEGFR) targeted therapies in non-small-cell lung cancer (NSCLC). These targeted therapies include neutralizing antibodies to VEGF (bevacizumab and aflibercept) and VEGFR-2 (ramucirumab) and tyrosine kinase inhibitors (TKIs) with selectivity for the VEGFRs. Bevacizumab and ramucirumab are associated with survival advantages in the treatment of advanced NSCLC: bevacizumab in the first-line setting in combination with carboplatin/paclitaxel and ramucirumab in combination with docetaxel in the second-line setting. The VEGFR-2 TKIs have been associated with responses and improved progression-free survival in selected NSCLC settings; however, this level of activity has thus far been insufficient to confer significant survival advantages. This review will focus on the current state of VEGF targeted therapies in NSCLC.

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Conflict of Interest

Liza C. Villaruz and Mark A. Socinski declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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  1. Lung Cancer Program, University of Pittsburgh Cancer Institute, 5150 Centre Avenue, 5th Floor Cancer Pavilion, Room 567, Pittsburgh, PA, 15232, USA

    Liza C. Villaruz & Mark A. Socinski

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  1. Liza C. Villaruz
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  2. Mark A. Socinski
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Correspondence to Liza C. Villaruz.

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This article is part of the Topical Collection on Lung Cancer

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Villaruz, L.C., Socinski, M.A. The Role of Anti-angiogenesis in Non-small-cell Lung Cancer: an Update. Curr Oncol Rep 17, 26 (2015). https://doi.org/10.1007/s11912-015-0448-y

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