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Update on the Pathogenesis and Management of Pouchitis

  • Intra-abdominal Infections, Hepatitis, and Gastroenteritis (D Bobak, Section Editor)
  • Published:
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Abstract

Pouchitis is an inflammatory complication after restorative proctocolectomy and ileal pouch-anal anastomosis (IPAA). IPAA is the surgical treatment of choice in patients with ulcerative colitis (UC) who require colectomy. Initial episodes of acute pouchitis generally respond to antibiotics but significant numbers of cases eventually become dependent on or refractory to antibiotics. Management of chronic antibiotic refractory pouchitis is challenging and can ultimately lead to pouch failure. The etiopathogenesis is unknown though recent studies have implicated bacterial dysbiosis of the pouch microbiota, NOD2 polymorphism, and Clostridium difficile infection in the development of severe pouchitis. Early identification of risk factors can help in tailoring therapy and reducing cases of chronic pouchitis.

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Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

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Conflict of Interest

Saleem Chowdhry has no conflicts of interest. Jeffry Katz gave expert testimony for Tucker, Ellis, LLC. Dr. Katz received honoraria from AbbVie Inc. and Janssen Biotech Inc.

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This article does not contain any studies with human or animal subjects performed by the author.

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Authors and Affiliations

  1. Division of Gastroenterology and Liver Disease, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH, 44106-5066, USA

    Saleem Chowdhry & Jeffry A. Katz

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  1. Saleem Chowdhry
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  2. Jeffry A. Katz
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Correspondence to Jeffry A. Katz.

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This article is part of the Topical Collection on Intra-abdominal Infections, Hepatitis, and Gastroenteritis

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Chowdhry, S., Katz, J.A. Update on the Pathogenesis and Management of Pouchitis. Curr Infect Dis Rep 16, 442 (2014). https://doi.org/10.1007/s11908-014-0442-9

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  • DOI: https://doi.org/10.1007/s11908-014-0442-9

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