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Coreceptors and HIV-1 Pathogenesis

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Abstract

The major HIV-1 coreceptors, CCR5 and CXCR4, mediate virus entry into CD4+ cells and are therefore a critical component of the HIV-1 life cycle. Alterations in coreceptor preference as well as the efficiency and mechanism of interaction between HIV-1 and CCR5 and/or CXCR4 has a significant influence on viral tropism, progression of disease, and response to coreceptor antagonists. In addition, these alterations influence the susceptibility of CD4+ T-cell, monocyte, and dendritic cell subsets to infection and therefore, are important for several facets of HIV-1 pathogenesis including the establishment of latent reservoirs, trafficking, and transmission. This review highlights recent literature that has advanced our understanding of the role of coreceptors in HIV-1 pathogenesis.

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Disclosure

P. R. Gorry: scientific advisory board for ViiV Healthcare Australia; P. Ancuta: none.

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Authors and Affiliations

  1. Center for Virology, Burnet Institute, 85 Commercial Road, Melbourne, Victoria, Australia, 3004

    Paul R. Gorry

  2. Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia

    Paul R. Gorry

  3. Department of Medicine, Monash University, Melbourne, Australia

    Paul R. Gorry

  4. Department of Microbiology and Immunology, Université de Montréal, Montreal, Canada

    Petronela Ancuta

  5. CHUM-Research Center, Saint-Luc Hospital, Montreal, Canada

    Petronela Ancuta

  6. The French National Institute of Health and Medical Research Unit 743, Montreal, Canada

    Petronela Ancuta

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  1. Paul R. Gorry
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Gorry, P.R., Ancuta, P. Coreceptors and HIV-1 Pathogenesis. Curr HIV/AIDS Rep 8, 45–53 (2011). https://doi.org/10.1007/s11904-010-0069-x

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