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Alcohol Consumption, Diabetes Risk, and Cardiovascular Disease Within Diabetes

  • Lifestyle Management to Reduce Diabetes/Cardiovascular Risk (B Conway and H Keenan, Section Editors)
  • Published:
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Abstract

Purpose of Review

The purpose of the study is to examine and summarize studies reporting on the epidemiology, the risk of developing diabetes, and the cardiovascular effects on individuals with diabetes of different levels of alcohol consumption.

Recent Findings

Men consume more alcohol than women in populations with and without diabetes. Light-to-moderate alcohol consumption decreases the incidence of diabetes in the majority of the studies, whereas heavy drinkers and binge drinkers are at increased risk for diabetes. Among people with diabetes, light-to-moderate alcohol consumption reduces risks of cardiovascular diseases and all-cause mortality.

Summary

Alcohol consumption is less common among populations with diabetes compared to the general population. Moderate alcohol consumption reduces the risk of diabetes and, as in the general population, improves cardiovascular health in patients with diabetes. Type of alcoholic beverage, gender, and body mass index are factors that affect these outcomes.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Rimm EB, Giovannucci EL, Willett WC, Colditz GA, Ascherio A, Rosner B, et al. Prospective study of alcohol consumption and risk of coronary disease in men. Lancet. 1991;338(8765):464–8.

    Article  CAS  PubMed  Google Scholar 

  2. Maclure M. Demonstration of deductive meta-analysis: ethanol intake and risk of myocardial infarction. Epidemiol Rev. 1993;15(2):328–51.

    Article  CAS  PubMed  Google Scholar 

  3. Gaziano JM, Buring JE, Breslow JL, Goldhaber SZ, Rosner B, VanDenburgh M, et al. Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. N Engl J Med. 1993;329(25):1829–34. https://doi.org/10.1056/NEJM199312163292501.

    Article  CAS  PubMed  Google Scholar 

  4. Stampfer MJ, Colditz GA, Willett WC, Speizer FE, Hennekens CH. A prospective study of moderate alcohol consumption and the risk of coronary disease and stroke in women. N Engl J Med. 1988;319(5):267–73. https://doi.org/10.1056/NEJM198808043190503.

    Article  CAS  PubMed  Google Scholar 

  5. Corrao G, Rubbiati L, Bagnardi V, Zambon A, Poikolainen K. Alcohol and coronary heart disease: a meta-analysis. Addiction. 2000;95(10):1505–23.

    Article  CAS  PubMed  Google Scholar 

  6. Glasgow AM, Tynan D, Schwartz R, Hicks JM, Turek J, Driscol C, et al. Alcohol and drug use in teenagers with diabetes mellitus. J Adolesc Health. 1991;12(1):11–4.

    Article  CAS  PubMed  Google Scholar 

  7. Ramchandani N, Cantey-Kiser JM, Alter CA, Brink SJ, Yeager SD, Tamborlane WV, et al. Self-reported factors that affect glycemic control in college students with type 1 diabetes. Diabetes Educ. 2000;26(4):656–66. https://doi.org/10.1177/014572170002600413.

    Article  CAS  PubMed  Google Scholar 

  8. Gold MA, Gladstein J. Substance use among adolescents with diabetes mellitus: preliminary findings. J Adolesc Health. 1993;14(2):80–4.

    Article  CAS  PubMed  Google Scholar 

  9. Martinez-Aguayo A, Araneda JC, Fernandez D, Gleisner A, Perez V, Codner E. Tobacco, alcohol, and illicit drug use in adolescents with diabetes mellitus. Pediatr Diabetes. 2007;8(5):265–71. https://doi.org/10.1111/j.1399-5448.2007.00307.x.

    Article  PubMed  Google Scholar 

  10. Hanna KM, Stupiansky NW, Weaver MT, Slaven JE, Stump TE. Alcohol use trajectories after high school graduation among emerging adults with type 1 diabetes. J Adolesc Health. 2014;55(2):201–8. https://doi.org/10.1016/j.jadohealth.2014.02.002.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Gafvels C, Lithner F. Lifestyle as regards physical exercise, smoking and drinking, of adult insulin-treated diabetic people compared with non-diabetic controls. Scand J Soc Med. 1997;25(3):168–75.

    Article  CAS  PubMed  Google Scholar 

  12. Gallagher A, Connolly V, Kelly WF. Alcohol consumption in patients with diabetes mellitus. Diabet Med. 2001;18(1):72–3.

    Article  CAS  PubMed  Google Scholar 

  13. Jakobsen ML, Larsen JR, Glumer C, Juel K, Ekholm O, Vilsboll T, et al. Alcohol consumption among patients with diabetes: a survey-based cross-sectional study of Danish adults with diabetes. Scand J Public Health. 2016;44(5):517–24. https://doi.org/10.1177/1403494816645223.

    Article  PubMed  Google Scholar 

  14. •• Blomster JI, Zoungas S, Chalmers J, Li Q, Chow CK, Woodward M, et al. The relationship between alcohol consumption and vascular complications and mortality in individuals with type 2 diabetes. Diabetes Care. 2014;37(5):1353–9. https://doi.org/10.2337/dc13-2727. The ADVANCE trial is a large, multi-country prospective study. This paper reports cardiovascular events and mortality rates among people with T2DM over time, based on amount and type of alcohol consumed.

    Article  CAS  PubMed  Google Scholar 

  15. Vaeth PA, Caetano R, Durazo EM. Ethnicity and alcohol consumption among US adults with diabetes. Ann Epidemiol. 2014;24(10):720–6. https://doi.org/10.1016/j.annepidem.2014.07.007.

    Article  PubMed  PubMed Central  Google Scholar 

  16. Beulens JW, Algra A, Soedamah-Muthu SS, Visseren FL, Grobbee DE, van der Graaf Y. Alcohol consumption and risk of recurrent cardiovascular events and mortality in patients with clinically manifest vascular disease and diabetes mellitus: the Second Manifestations of ARTerial (SMART) disease study. Atherosclerosis. 2010;212(1):281–6. https://doi.org/10.1016/j.atherosclerosis.2010.04.034.

    Article  CAS  PubMed  Google Scholar 

  17. French MT, Mundt MP, Fleming M, Zavala SK. The cost of medical care for patients with diabetes, hypertension and both conditions: does alcohol use play a role? J Intern Med. 2005;258(1):45–54. https://doi.org/10.1111/j.1365-2796.2005.01501.x.

    Article  CAS  PubMed  Google Scholar 

  18. Mukamal KJ. Hazardous drinking among adults with diabetes and related eye disease or visual problems: a population-based cross-sectional survey. Ophthalmic Epidemiol. 2007;14(1):45–9. https://doi.org/10.1080/09286580601001339.

    Article  PubMed  Google Scholar 

  19. Hodge AM, English DR, O’Dea K, Giles GG. Alcohol intake, consumption pattern and beverage type, and the risk of type 2 diabetes. Diabet Med. 2006;23(6):690–7. https://doi.org/10.1111/j.1464-5491.2006.01864.x.

    Article  CAS  PubMed  Google Scholar 

  20. Shi L, Shu XO, Li H, Cai H, Liu Q, Zheng W, et al. Physical activity, smoking, and alcohol consumption in association with incidence of type 2 diabetes among middle-aged and elderly Chinese men. PLoS One. 2013;8(11):e77919. https://doi.org/10.1371/journal.pone.0077919.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Carlsson S, Hammar N, Grill V, Kaprio J. Alcohol consumption and the incidence of type 2 diabetes: a 20-year follow-up of the Finnish twin cohort study. Diabetes Care. 2003;26(10):2785–90.

    Article  PubMed  Google Scholar 

  22. • Fagherazzi G, Vilier A, Lajous M, Boutron-Ruault MC, Balkau B, Clavel-Chapelon F, et al. Wine consumption throughout life is inversely associated with type 2 diabetes risk, but only in overweight individuals: results from a large female French cohort study. Eur J Epidemiol. 2014;29(11):831–9. https://doi.org/10.1007/s10654-014-9955-7. This study compared different spirits and effects of alcohol consumption on diabetes risk by gender and body mass indices.

    Article  CAS  PubMed  Google Scholar 

  23. Waki K, Noda M, Sasaki S, Matsumura Y, Takahashi Y, Isogawa A, et al. Alcohol consumption and other risk factors for self-reported diabetes among middle-aged Japanese: a population-based prospective study in the JPHC study cohort I. Diabet Med. 2005;22(3):323–31. https://doi.org/10.1111/j.1464-5491.2004.01403.x.

    Article  CAS  PubMed  Google Scholar 

  24. Sato KK, Hayashi T, Harita N, Koh H, Maeda I, Endo G, et al. Relationship between drinking patterns and the risk of type 2 diabetes: the Kansai Healthcare Study. J Epidemiol Community Health. 2012;66(6):507–11. https://doi.org/10.1136/jech.2010.109777.

    Article  PubMed  Google Scholar 

  25. Wakabayashi I. Light-to-moderate alcohol drinking reduces the impact of obesity on the risk of diabetes mellitus. J Stud Alcohol Drugs. 2014;75(6):1032–8.

    Article  PubMed  Google Scholar 

  26. Hong SW, Linton JA, Shim JY, Kang HT. High-risk drinking is associated with a higher risk of diabetes mellitus in Korean men, based on the 2010-2012 KNHANES. Alcohol (Fayetteville, NY). 2015;49(3):275–81. https://doi.org/10.1016/j.alcohol.2015.02.004.

    Article  Google Scholar 

  27. Beulens JW, Stolk RP, van der Schouw YT, Grobbee DE, Hendriks HF, Bots ML. Alcohol consumption and risk of type 2 diabetes among older women. Diabetes Care. 2005;28(12):2933–8.

    Article  PubMed  Google Scholar 

  28. Joosten MM, Grobbee DE, van Der AD, Verschuren WM, Hendriks HF, Beulens JW. Combined effect of alcohol consumption and lifestyle behaviors on risk of type 2 diabetes. Am J Clin Nutr. 2010;91(6):1777–83. https://doi.org/10.3945/ajcn.2010.29170.

    Article  CAS  PubMed  Google Scholar 

  29. Kao WH, Puddey IB, Boland LL, Watson RL, Brancati FL. Alcohol consumption and the risk of type 2 diabetes mellitus: atherosclerosis risk in communities study. Am J Epidemiol. 2001;154(8):748–57.

    Article  CAS  PubMed  Google Scholar 

  30. Boggs DA, Rosenberg L, Ruiz-Narvaez EA, Palmer JR. Coffee, tea, and alcohol intake in relation to risk of type 2 diabetes in African American women. Am J Clin Nutr. 2010;92(4):960–6. https://doi.org/10.3945/ajcn.2010.29598.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Rimm EB, Chan J, Stampfer MJ, Colditz GA, Willett WC. Prospective study of cigarette smoking, alcohol use, and the risk of diabetes in men. BMJ (Clinical research ed). 1995;310(6979):555–9.

    Article  CAS  Google Scholar 

  32. Conigrave KM, Hu BF, Camargo CA Jr, Stampfer MJ, Willett WC, Rimm EB. A prospective study of drinking patterns in relation to risk of type 2 diabetes among men. Diabetes. 2001;50(10):2390–5.

    Article  CAS  PubMed  Google Scholar 

  33. Stampfer MJ, Colditz GA, Willett WC, Manson JE, Arky RA, Hennekens CH, et al. A prospective study of moderate alcohol drinking and risk of diabetes in women. Am J Epidemiol. 1988;128(3):549–58.

    Article  CAS  PubMed  Google Scholar 

  34. Wannamethee SG, Camargo CA Jr, Manson JE, Willett WC, Rimm EB. Alcohol drinking patterns and risk of type 2 diabetes mellitus among younger women. Arch Intern Med. 2003;163(11):1329–36. https://doi.org/10.1001/archinte.163.11.1329.

    Article  PubMed  Google Scholar 

  35. Ajani UA, Hennekens CH, Spelsberg A, Manson JE. Alcohol consumption and risk of type 2 diabetes mellitus among US male physicians. Arch Intern Med. 2000;160(7):1025–30.

    Article  CAS  PubMed  Google Scholar 

  36. Mekary RA, Rimm EB, Giovannucci E, Stampfer MJ, Willett WC, Ludwig DS, et al. Joint association of glycemic load and alcohol intake with type 2 diabetes incidence in women. Am J Clin Nutr. 2011;94(6):1525–32. https://doi.org/10.3945/ajcn.111.023754.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Joosten MM, Chiuve SE, Mukamal KJ, Hu FB, Hendriks HF, Rimm EB. Changes in alcohol consumption and subsequent risk of type 2 diabetes in men. Diabetes. 2011;60(1):74–9. https://doi.org/10.2337/db10-1052.

    Article  CAS  PubMed  Google Scholar 

  38. Beulens JW, Rimm EB, Hendriks HF, Hu FB, Manson JE, Hunter DJ, et al. Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase. Diabetes. 2007;56(9):2388–94. https://doi.org/10.2337/db07-0181.

    Article  CAS  PubMed  Google Scholar 

  39. Lapidus L, Bengtsson C, Bergfors E, Bjorkelund C, Spak F, Lissner L. Alcohol intake among women and its relationship to diabetes incidence and all-cause mortality: the 32-year follow-up of a population study of women in Gothenburg, Sweden. Diabetes Care. 2005;28(9):2230–5.

    Article  PubMed  Google Scholar 

  40. Adjemian MK, Volpe RJ, Adjemian J. Relationships between diet, alcohol preference, and heart disease and type 2 diabetes among Americans. PLoS One. 2015;10(5):e0124351. https://doi.org/10.1371/journal.pone.0124351.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  41. Teratani T, Morimoto H, Sakata K, Oishi M, Tanaka K, Nakada S, et al. Dose-response relationship between tobacco or alcohol consumption and the development of diabetes mellitus in Japanese male workers. Drug Alcohol Depend. 2012;125(3):276–82. https://doi.org/10.1016/j.drugalcdep.2012.03.002.

    Article  CAS  PubMed  Google Scholar 

  42. Imamura F, Lichtenstein AH, Dallal GE, Meigs JB, Jacques PF. Confounding by dietary patterns of the inverse association between alcohol consumption and type 2 diabetes risk. Am J Epidemiol. 2009;170(1):37–45. https://doi.org/10.1093/aje/kwp096.

    Article  PubMed  PubMed Central  Google Scholar 

  43. Koloverou E, Panagiotakos DB, Pitsavos C, Chrysohoou C, Georgousopoulou EN, Metaxa V, et al. Effects of alcohol consumption and the metabolic syndrome on 10-year incidence of diabetes: the ATTICA study. Diabetes Metab. 2015;41(2):152–9. https://doi.org/10.1016/j.diabet.2014.06.003.

    Article  CAS  PubMed  Google Scholar 

  44. Rasouli B, Andersson T, Carlsson PO, Dorkhan M, Grill V, Groop L, et al. Alcohol and the risk for latent autoimmune diabetes in adults: results based on Swedish ESTRID study. Eur J Endocrinol. 2014;171(5):535–43. https://doi.org/10.1530/eje-14-0403.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Djousse L, Biggs ML, Mukamal KJ, Siscovick DS. Alcohol consumption and type 2 diabetes among older adults: the Cardiovascular Health Study. Obesity (Silver Spring, Md). 2007;15(7):1758–65. https://doi.org/10.1038/oby.2007.209.

    Article  Google Scholar 

  46. Crandall JP, Polsky S, Howard AA, Perreault L, Bray GA, Barrett-Connor E, et al. Alcohol consumption and diabetes risk in the Diabetes Prevention Program. Am J Clin Nutr. 2009;90(3):595–601. https://doi.org/10.3945/ajcn.2008.27382.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Marques-Vidal P, Vollenweider P, Waeber G. Alcohol consumption and incidence of type 2 diabetes. Results from the CoLaus study. Nutr Metab Cardiovasc Dis: NMCD. 2015;25(1):75–84. https://doi.org/10.1016/j.numecd.2014.08.010.

    Article  CAS  PubMed  Google Scholar 

  48. Wei M, Gibbons LW, Mitchell TL, Kampert JB, Blair SN. Alcohol intake and incidence of type 2 diabetes in men. Diabetes Care. 2000;23(1):18–22.

    Article  CAS  PubMed  Google Scholar 

  49. Wannamethee SG, Shaper AG, Perry IJ, Alberti KG. Alcohol consumption and the incidence of type II diabetes. J Epidemiol Community Health. 2002;56(7):542–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  50. Athyros VG, Liberopoulos EN, Mikhailidis DP, Papageorgiou AA, Ganotakis ES, Tziomalos K, et al. Association of drinking pattern and alcohol beverage type with the prevalence of metabolic syndrome, diabetes, coronary heart disease, stroke, and peripheral arterial disease in a Mediterranean cohort. Angiology. 2007;58(6):689–97. https://doi.org/10.1177/0003319707306146.

    Article  PubMed  Google Scholar 

  51. Nakanishi N, Suzuki K, Tatara K. Alcohol consumption and risk for development of impaired fasting glucose or type 2 diabetes in middle-aged Japanese men. Diabetes Care. 2003;26(1):48–54.

    Article  PubMed  Google Scholar 

  52. Liu C, Yu Z, Li H, Wang J, Sun L, Qi Q, et al. Associations of alcohol consumption with diabetes mellitus and impaired fasting glycemia among middle-aged and elderly Chinese. BMC Public Health. 2010;10:713. https://doi.org/10.1186/1471-2458-10-713.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Kerr WC, Ye Y. Relationship of life-course drinking patterns to diabetes, heart problems, and hypertension among those 40 and older in the 2005 U.S. National Alcohol Survey. J Stud Alcohol Drugs. 2010;71(4):515–25.

    Article  PubMed  PubMed Central  Google Scholar 

  54. de Vegt F, Dekker JM, Groeneveld WJ, Nijpels G, Stehouwer CD, Bouter LM, et al. Moderate alcohol consumption is associated with lower risk for incident diabetes and mortality: the Hoorn Study. Diabetes Res Clin Pract. 2002;57(1):53–60.

    Article  PubMed  Google Scholar 

  55. Clerc O, Nanchen D, Cornuz J, Marques-Vidal P, Gmel G, Daeppen JB, et al. Alcohol drinking, the metabolic syndrome and diabetes in a population with high mean alcohol consumption. Diabet Med. 2010;27(11):1241–9. https://doi.org/10.1111/j.1464-5491.2010.03094.x.

    Article  CAS  PubMed  Google Scholar 

  56. Carlsson S, Hammar N, Efendic S, Persson PG, Ostenson CG, Grill V. Alcohol consumption, type 2 diabetes mellitus and impaired glucose tolerance in middle-aged Swedish men. Diabet Med. 2000;17(11):776–81.

    Article  CAS  PubMed  Google Scholar 

  57. Liang W, Chikritzhs T. Alcohol consumption during adolescence and risk of diabetes in young adulthood. Biomed Res Int. 2014;2014:795741. https://doi.org/10.1155/2014/795741.

    PubMed  PubMed Central  Google Scholar 

  58. Johnson KH, Bazargan M, Cherpitel CJ. Alcohol, tobacco, and drug use and the onset of type 2 diabetes among inner-city minority patients. J Am Board Fam Pract. 2001;14(6):430–6.

    CAS  PubMed  Google Scholar 

  59. Heianza Y, Arase Y, Saito K, Tsuji H, Fujihara K, Hsieh SD, et al. Role of alcohol drinking pattern in type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center Study 11 (TOPICS 11). Am J Clin Nutr. 2013;97(3):561–8. https://doi.org/10.3945/ajcn.112.043364.

    Article  CAS  PubMed  Google Scholar 

  60. Sakai Y, Yamaji T, Tabata S, Ogawa S, Yamaguchi K, Mineshita M, et al. Relation of alcohol use and smoking to glucose tolerance status in Japanese men. Diabetes Res Clin Pract. 2006;73(1):83–8. https://doi.org/10.1016/j.diabres.2005.12.010.

    Article  CAS  PubMed  Google Scholar 

  61. Jang H, Jang WM, Park JH, Oh J, Oh MK, Hwang SH, et al. Alcohol consumption and the risk of type 2 diabetes mellitus: effect modification by hypercholesterolemia: the Third Korea National Health and Nutrition Examination Survey (2005). Asia Pac J Clin Nutr. 2012;21(4):588–93.

    PubMed  Google Scholar 

  62. Saremi A, Hanson RL, Tulloch-Reid M, Williams DE, Knowler WC. Alcohol consumption predicts hypertension but not diabetes. J Stud Alcohol. 2004;65(2):184–90.

    Article  PubMed  Google Scholar 

  63. Hodge AM, Dowse GK, Collins VR, Zimmet PZ. Abnormal glucose tolerance and alcohol consumption in three populations at high risk of non-insulin-dependent diabetes mellitus. Am J Epidemiol. 1993;137(2):178–89.

    Article  CAS  PubMed  Google Scholar 

  64. Rasouli B, Ahlbom A, Andersson T, Grill V, Midthjell K, Olsson L, et al. Alcohol consumption is associated with reduced risk of type 2 diabetes and autoimmune diabetes in adults: results from the Nord-Trondelag health study. Diabet Med. 2013;30(1):56–64. https://doi.org/10.1111/j.1464-5491.2012.03713.x.

    Article  CAS  PubMed  Google Scholar 

  65. Cullmann M, Hilding A, Ostenson CG. Alcohol consumption and risk of pre-diabetes and type 2 diabetes development in a Swedish population. Diabet Med. 2012;29(4):441–52. https://doi.org/10.1111/j.1464-5491.2011.03450.x.

    Article  CAS  PubMed  Google Scholar 

  66. Holbrook TL, Barrett-Connor E, Wingard DL. A prospective population-based study of alcohol use and non-insulin-dependent diabetes mellitus. Am J Epidemiol. 1990;132(5):902–9.

    Article  CAS  PubMed  Google Scholar 

  67. Wandell PE, de Faire U, Hellenius ML. High intake of alcohol is associated with newly diagnosed diabetes in 60 years old men and women. Nutr Metab Cardiovasc Dis: NMCD. 2007;17(8):598–608. https://doi.org/10.1016/j.numecd.2006.05.005.

    Article  CAS  PubMed  Google Scholar 

  68. Metcalf PA, Scragg RK, Jackson R. Light to moderate alcohol consumption is protective for type 2 diabetes mellitus in normal weight and overweight individuals but not the obese. J Obes. 2014;2014:634587. https://doi.org/10.1155/2014/634587.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  69. Roh WG, Shin HC, Choi JH, Lee YJ, Kim K. Alcohol consumption and higher incidence of impaired fasting glucose or type 2 diabetes in obese Korean men. Alcohol (Fayetteville, NY). 2009;43(8):643–8. https://doi.org/10.1016/j.alcohol.2009.10.005.

    Article  CAS  Google Scholar 

  70. Watanabe M, Barzi F, Neal B, Ueshima H, Miyoshi Y, Okayama A, et al. Alcohol consumption and the risk of diabetes by body mass index levels in a cohort of 5,636 Japanese. Diabetes Res Clin Pract. 2002;57(3):191–7.

    Article  PubMed  Google Scholar 

  71. Tsumura K, Hayashi T, Suematsu C, Endo G, Fujii S, Okada K. Daily alcohol consumption and the risk of type 2 diabetes in Japanese men: the Osaka Health Survey. Diabetes Care. 1999;22(9):1432–7.

    Article  CAS  PubMed  Google Scholar 

  72. Kawamoto R, Kohara K, Tabara Y, Miki T, Ohtsuka N, Kusunoki T, et al. Alcohol consumption is associated with decreased insulin resistance independent of body mass index in Japanese community-dwelling men. Tohoku J Exp Med. 2009;218(4):331–7.

    Article  CAS  PubMed  Google Scholar 

  73. Beulens JW, van der Schouw YT, Moons KG, Boshuizen HC, van der A D, Groenwold RH. Estimating the mediating effect of different biomarkers on the relation of alcohol consumption with the risk of type 2 diabetes. Ann Epidemiol. 2013;23(4):193–7. https://doi.org/10.1016/j.annepidem.2012.12.014.

    Article  PubMed  Google Scholar 

  74. Rohwer RD, Liu S, You NC, Buring JE, Manson JE, Song Y. Interrelationship between alcohol intake and endogenous sex-steroid hormones on diabetes risk in postmenopausal women. J Am Coll Nutr. 2015;34(4):273–80. https://doi.org/10.1080/07315724.2014.926163.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  75. Beulens JW, Rimm EB, Hu FB, Hendriks HF, Mukamal KJ. Alcohol consumption, mediating biomarkers, and risk of type 2 diabetes among middle-aged women. Diabetes Care. 2008;31(10):2050–5. https://doi.org/10.2337/dc08-0814.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  76. Scragg R, Metcalf P. Do triglycerides explain the U-shaped relation between alcohol and diabetes risk? Results from a cross-sectional survey of alcohol and plasma glucose. Diabetes Res Clin Pract. 2004;66(2):147–56. https://doi.org/10.1016/j.diabres.2004.02.022.

    Article  CAS  PubMed  Google Scholar 

  77. Wakabayashi I. Association between alcohol drinking and metabolic syndrome in Japanese male workers with diabetes mellitus. J Atheroscler Thromb. 2011;18(8):684–92.

    Article  CAS  PubMed  Google Scholar 

  78. Shimomura T, Wakabayashi I. Inverse associations between light-to-moderate alcohol intake and lipid-related indices in patients with diabetes. Cardiovasc Diabetol. 2013;12:104. https://doi.org/10.1186/1475-2840-12-104.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Pitsavos C, Makrilakis K, Panagiotakos DB, Chrysohoou C, Ioannidis I, Dimosthenopoulos C, et al. The J-shape effect of alcohol intake on the risk of developing acute coronary syndromes in diabetic subjects: the CARDIO2000 II Study. Diabet Med. 2005;22(3):243–8. https://doi.org/10.1111/j.1464-5491.2004.01384.x.

    Article  CAS  PubMed  Google Scholar 

  80. Wakabayashi I. Comparison of the relationships of alcohol intake with atherosclerotic risk factors in men with and without diabetes mellitus. Alcohol Alcohol (Oxford, Oxfordshire). 2011;46(3):301–7. https://doi.org/10.1093/alcalc/agr006.

    Article  CAS  Google Scholar 

  81. Tanasescu M, Hu FB, Willett WC, Stampfer MJ, Rimm EB. Alcohol consumption and risk of coronary heart disease among men with type 2 diabetes mellitus. J Am Coll Cardiol. 2001;38(7):1836–42.

    Article  CAS  PubMed  Google Scholar 

  82. Ajani UA, Gaziano JM, Lotufo PA, Liu S, Hennekens CH, Buring JE, et al. Alcohol consumption and risk of coronary heart disease by diabetes status. Circulation. 2000;102(5):500–5.

    Article  CAS  PubMed  Google Scholar 

  83. Solomon CG, Hu FB, Stampfer MJ, Colditz GA, Speizer FE, Rimm EB, et al. Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus. Circulation. 2000;102(5):494–9.

    Article  CAS  PubMed  Google Scholar 

  84. Rajpathak SN, Freiberg MS, Wang C, Wylie-Rosett J, Wildman RP, Rohan TE, et al. Alcohol consumption and the risk of coronary heart disease in postmenopausal women with diabetes: Women’s Health Initiative Observational Study. Eur J Nutr. 2010;49(4):211–8. https://doi.org/10.1007/s00394-009-0065-3.

    Article  CAS  PubMed  Google Scholar 

  85. Regan TJ. Moderate alcohol consumption and risk of coronary heart disease among women with type 2 diabetes mellitus. Circulation. 2000;102(5):487–8.

    Article  CAS  PubMed  Google Scholar 

  86. Wakabayashi I, Kobaba-Wakabayashi R, Masuda H. Relation of drinking alcohol to atherosclerotic risk in type 2 diabetes. Diabetes Care. 2002;25(7):1223–8.

    Article  PubMed  Google Scholar 

  87. Wakabayashi I, Masuda H. Influence of drinking alcohol on atherosclerotic risk in alcohol flushers and non-flushers of Oriental patients with type 2 diabetes mellitus. Alcohol Alcohol (Oxford, Oxfordshire). 2006;41(6):672–7. https://doi.org/10.1093/alcalc/agl067.

    Article  CAS  Google Scholar 

  88. Keilman PA. Alcohol consumption and diabetes mellitus mortality in different countries. Am J Public Health. 1983;73(11):1316–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Sluik D, Boeing H, Bergmann MM, Schutze M, Teucher B, Kaaks R, et al. Alcohol consumption and mortality in individuals with diabetes mellitus. Br J Nutr. 2012;108(7):1307–15. https://doi.org/10.1017/s0007114511006532.

    Article  CAS  PubMed  Google Scholar 

  90. Balkau B, Eschwege E, Fontbonne A, Claude JR, Warnet JM. Cardiovascular and alcohol-related deaths in abnormal glucose tolerant and diabetic subjects. Diabetologia. 1992;35(1):39–44.

    Article  CAS  PubMed  Google Scholar 

  91. Diem P, Deplazes M, Fajfr R, Bearth A, Muller B, Christ ER, et al. Effects of alcohol consumption on mortality in patients with type 2 diabetes mellitus. Diabetologia. 2003;46(11):1581–5. https://doi.org/10.1007/s00125-003-1209-2.

    Article  CAS  PubMed  Google Scholar 

  92. Valmadrid CT, Klein R, Moss SE, Klein BE, Cruickshanks KJ. Alcohol intake and the risk of coronary heart disease mortality in persons with older-onset diabetes mellitus. JAMA. 1999;282(3):239–46.

    Article  CAS  PubMed  Google Scholar 

  93. Nakamura Y, Ueshima H, Kadota A, Hozawa A, Okamura T, Kadowaki S, et al. Alcohol intake and 19-year mortality in diabetic men: NIPPON DATA80. Alcohol (Fayetteville, NY). 2009;43(8):635–41. https://doi.org/10.1016/j.alcohol.2009.06.005.

    Article  CAS  Google Scholar 

  94. Onat A, Hergenc G, Kucukdurmaz Z, Ugur M, Kaya Z, Can G, et al. Moderate and heavy alcohol consumption among Turks: long-term impact on mortality and cardiometabolic risk. Turk Kardiyoloji Dernegi Arsivi. 2009;37(2):83–90.

    PubMed  Google Scholar 

  95. Fukui M, Kitagawa Y, Nakamura N, Kadono M, Hasegawa G, Yoshikawa T. Association between alcohol consumption and serum dehydroepiandrosterone sulphate concentration in men with type 2 diabetes: a link to decreased cardiovascular risk. Diabet Med. 2005;22(10):1446–50. https://doi.org/10.1111/j.1464-5491.2005.01629.x.

    Article  CAS  PubMed  Google Scholar 

  96. Taylor AE, Lu F, Carslake D, Hu Z, Qian Y, Liu S, et al. Exploring causal associations of alcohol with cardiovascular and metabolic risk factors in a Chinese population using Mendelian randomization analysis. Sci Rep. 2015;5:14005. https://doi.org/10.1038/srep14005.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  97. Sakuta H, Suzuki T, Katayama Y, Yasuda H, Ito T. Heavy alcohol intake, homocysteine and type 2 diabetes. Diabet Med. 2005;22(10):1359–63. https://doi.org/10.1111/j.1464-5491.2005.01653.x.

    Article  CAS  PubMed  Google Scholar 

  98. Sakuta H, Suzuki T, Ito T, Yasuda H. Beer ethanol consumption and plasma homocysteine among patients with type 2 diabetes. Diabetes Res Clin Pract. 2007;78(2):202–7. https://doi.org/10.1016/j.diabres.2007.03.016.

    Article  CAS  PubMed  Google Scholar 

  99. Gepner Y, Golan R, Harman-Boehm I, Henkin Y, Schwarzfuchs D, Shelef I, et al. Effects of initiating moderate alcohol intake on cardiometabolic risk in adults with type 2 diabetes: a 2-year randomized, controlled trial. Ann Intern Med. 2015;163(8):569–79. https://doi.org/10.7326/m14-1650.

    Article  PubMed  Google Scholar 

  100. Jain M, Wernick R, ACP Journal Club. In abstinent adults with type 2 diabetes, a daily glass of wine (vs mineral water) improved cardiometabolic factors. Ann Intern Med. 2016;164(4):Jc17. https://doi.org/10.7326/acpjc-2016-164-4-017.

    Article  PubMed  Google Scholar 

  101. Mori TA, Burke V, Zilkens RR, Hodgson JM, Beilin LJ, Puddey IB. The effects of alcohol on ambulatory blood pressure and other cardiovascular risk factors in type 2 diabetes: a randomized intervention. J Hypertens. 2016;34(3):421–428; discussion 8. https://doi.org/10.1097/hjh.0000000000000816.

    Article  CAS  PubMed  Google Scholar 

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  1. Barbara Davis Center for Diabetes, University of Colorado Denver, 1775 Aurora Court, MS A140, Aurora, CO, 80045, USA

    Sarit Polsky & Halis K. Akturk

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  1. Sarit Polsky
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Sarit Polsky and Halis K. Akturk declare that they have no conflict of interest.

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This article does not contain any studies with animal subjects performed by any of the authors. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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This article is part of the Topical Collection on Lifestyle Management to Reduce Diabetes/Cardiovascular Risk

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Polsky, S., Akturk, H.K. Alcohol Consumption, Diabetes Risk, and Cardiovascular Disease Within Diabetes. Curr Diab Rep 17, 136 (2017). https://doi.org/10.1007/s11892-017-0950-8

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