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Apolipoprotein A-I mimetic peptides

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Abstract

Recent publications reveal the mechanism of action of apolipoprotein A-I (apoA-I) mimetic peptides to be the remarkable binding affinity that oxidized lipids have for these peptides compared with apoA-I. There was no difference in the binding affinity of oxidized lipids or in peptide efficacy in reducing inflammation and atherosclerosis in rabbits injected with peptides synthesized from all D- or all L-amino acids. The apoA-I mimetic peptide 4F increased the formation of pre-β high-density lipoprotein, increased cholesterol efflux, and reduced lipoprotein oxidation in vitro; it increased antioxidants and vascular repair in type 1 diabetic rats; it improved vasodilation, oxidative stress, myocardial inflammation, and angiogenic potential in a mouse model of scleroderma; it reduced renal inflammation in low-density lipoprotein receptor-null mice fed a Western diet; it reduced arthritis in a rat model; it reduced adiposity, increased adiponectin levels, and improved insulin sensitivity in obese mice; and it improved high-density lipoprotein inflammatory properties in humans with coronary heart disease.

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Authors and Affiliations

  1. Room BH-307 CHS, Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA

    Brian J. Van Lenten

Authors
  1. Brian J. Van Lenten
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  2. Alan C. Wagner
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  3. G. M. Anantharamaiah
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  4. Mohamad Navab
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  5. Srinivasa T. Reddy
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  6. Georgette M. Buga
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  7. Alan M. Fogelman
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Correspondence to Brian J. Van Lenten.

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Van Lenten, B.J., Wagner, A.C., Anantharamaiah, G.M. et al. Apolipoprotein A-I mimetic peptides. Curr Atheroscler Rep 11, 52–57 (2009). https://doi.org/10.1007/s11883-009-0008-8

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  • DOI: https://doi.org/10.1007/s11883-009-0008-8

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