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Mechanisms Controlling Mast Cell and Basophil Lineage Decisions

  • BASIC AND APPLIED SCIENCE (M FRIERI AND PJ BRYCE, SECTION EDITORS)
  • Published:
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Abstract

Basophils and mast cells have long been known to play critical roles in allergic disease and host defense against parasitic infections. Recent recognition of these effector cells in immune regulations, host defense against bacteria and virus, and autoimmune diseases entices increased interest in studying these cells. However, origin and molecular regulation of basophil and mast cell differentiation remain incompletely understood. In this review, we focus on recent advances of the understanding the origin and molecular regulation of mouse basophil and mast cell development. We also summarize progress in the understanding of the origin and molecular regulation of human basophil and mast cell development. A more complete understanding of molecular regulation of basophils and mast cells will lead to the development of interventions that are more effective in achieving long-term success.

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Acknowledgments

This work is supported by grant from the National Institutes of Health (RO1AI083986).

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Hua Huang and Yapeng Li declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Biomedical Research, National Jewish Health, 1400 Jackson Street, K613e, Denver, CO, 80206, USA

    Hua Huang & Yapeng Li

  2. Department of Immunology and Microbiology, University of Colorado School of Medicine, 1400 Jackson Street, K613e, Denver, CO, 80206, USA

    Hua Huang & Yapeng Li

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Correspondence to Hua Huang.

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Huang, H., Li, Y. Mechanisms Controlling Mast Cell and Basophil Lineage Decisions. Curr Allergy Asthma Rep 14, 457 (2014). https://doi.org/10.1007/s11882-014-0457-1

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