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Process synthesis and optimization for the isolation and purification of paclitaxel from Taxus chinensis

  • Biotechnology
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Abstract

Cavitation extraction, water/hexane washing, and cavitation precipitation-based process synthesis and optimization were performed for the isolation and purification of biomass-derived paclitaxel. The final purity, overall yield, and operating time were significantly improved when negative pressure cavitation extraction was followed by sequential washing with water and hexane, adsorbent treatment, and negative pressure cavitation fractional precipitation using acetone-pentane and methanol-water. This procedure showed a purity and yield increase of 11.0–45.6% and 2.2–29.6%, respectively, and an operating time reduction of 56.2–98.3% compared to the traditional methods.

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Acknowledgements

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Government of Korea (MSIT) (Grant Number: 2021R1A2C1003186).

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Authors and Affiliations

  1. Center for Future Sustainable Technology, Department of Chemical Engineering, Kongju National University, Cheonan, 31080, Korea

    Hye-Su Min & Jin-Hyun Kim

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  1. Hye-Su Min
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  2. Jin-Hyun Kim
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Correspondence to Jin-Hyun Kim.

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Min, HS., Kim, JH. Process synthesis and optimization for the isolation and purification of paclitaxel from Taxus chinensis. Korean J. Chem. Eng. 39, 3389–3398 (2022). https://doi.org/10.1007/s11814-022-1261-6

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  • DOI: https://doi.org/10.1007/s11814-022-1261-6

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