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Removal of residual chloroform from amorphous paclitaxel pretreated by alcohol

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Abstract

A drying method that can effectively remove residual solvents from chloroform-induced amorphous paclitaxel was developed. Simple rotary evaporation with alcohol (methanol or ethanol) pretreatment was sufficient to remove residual chloroform and alcohol concentrations below the ICH limits (60 ppm for chloroform, 3,000 ppm for methanol, and 5,000 ppm for ethanol). In addition, SEM analysis and ultrasonic treatment showed that residual solvent removal is related to the porous structure of the sample due to the high vapor pressure of the chloroform-alcohol mixture and the hydrogen bonding between chloroform and alcohol.

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Acknowledgements

This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (Grant Number: 2018R1D1A3A03000683).

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Authors and Affiliations

  1. Department of Chemical Engineering, Kongju National University, Cheonan, 31080, Korea

    Hoe-Jong Kang & Jin-Hyun Kim

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  1. Hoe-Jong Kang
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  2. Jin-Hyun Kim
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Correspondence to Jin-Hyun Kim.

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Kang, HJ., Kim, JH. Removal of residual chloroform from amorphous paclitaxel pretreated by alcohol. Korean J. Chem. Eng. 36, 1965–1970 (2019). https://doi.org/10.1007/s11814-019-0413-9

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  • DOI: https://doi.org/10.1007/s11814-019-0413-9

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