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Physical decline and its implications in the management of oesophageal and gastric cancer: a systematic review

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Abstract

Purpose

The management of oesophageal and gastric cancer can cause significant physical decline, impacting on completion rates and outcomes. This systematic review aimed to (i) determine the impact of chemotherapy, chemoradiotherapy and surgery on physical function; (ii) identify associations between physical function and post-operative outcomes; and (iii) examine the effects of rehabilitation on physical function.

Methods

We included randomised controlled trials (RCT), non-RCTs of interventions and cohort studies that measured physical function by objective means in patients with oesophageal or gastric cancer. EMBASE, PubMed, CINAHL, Cochrane Library, SCOPUS, PEDro and the WHO Trial Registry were searched up to June 2016. Risk of bias assessment was performed using a suite of validated tools.

Results

Twenty-five studies involving 1897 participants were included. A meta-analysis was not indicated due to the heterogeneity of the literature. Significant reductions in physical function occur in patients undergoing neoadjuvant treatment and in the first 3 months post-resection. Lower pre-operative exercise capacity is associated with an increased risk of post-operative pulmonary complications (PPCs). Evidence to support exercise prehabilitation and rehabilitation in these treatment pathways is currently lacking.

Conclusions

Chemotherapy, chemoradiation and surgery lead to reduced physical function in patients with oesophageal and gastric cancer. High quality evidence is lacking to prove the benefit of interventions that improve physical function through the treatment pathway and in recovery, and well-designed studies are required. This review was limited due to the heterogeneity of the literature, high risk of bias in some articles and the lack of high quality research encompassing sufficient time points in the patient journey.

Implications for Cancer Survivors

Curative treatment for oesophago-gastric cancer can negatively impact on physical function. Rehabilitation programmes have considerable potential to enhance physical function across the oesophago-gastric cancer journey.

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References

  1. Barbour AP, Lagergren P, Hughes R, Alderson D, Barham CP, Blazeby JM. Health-related quality of life among patients with adenocarcinoma of the gastro-oesophageal junction treated by gastrectomy or oesophagectomy. Br J Surg. 2008;95(1):80–4. https://doi.org/10.1002/bjs.5912.

    Article  PubMed  CAS  Google Scholar 

  2. Kidane B, Coughlin S, Vogt K, Malthaner R. Preoperative chemotherapy for resectable thoracic esophageal cancer. Cochrane Database Syst Rev. 2015(5):Cd001556. doi:https://doi.org/10.1002/14651858.CD001556.pub3.

  3. van Meerten E, van der Gaast A, Looman CW, Tilanus HW, Muller K, Essink-Bot ML. Quality of life during neoadjuvant treatment and after surgery for resectable esophageal carcinoma. Int J Radiat Oncol Biol Phys. 2008;71(1):160–6. https://doi.org/10.1016/j.ijrobp.2007.09.038.

    Article  PubMed  Google Scholar 

  4. Ronellenfitsch U, Schwarzbach M, Hofheinz R, Kienle P, Kieser M, Slanger TE et al. Perioperative chemo(radio)therapy versus primary surgery for resectable adenocarcinoma of the stomach, gastroesophageal junction, and lower esophagus. Cochrane Database of Syst Rev. 2013(5):Cd008107. doi:https://doi.org/10.1002/14651858.CD008107.pub2.

  5. Carcas LP. Gastric cancer review. J Carcinogenesis. 2014;13:14. https://doi.org/10.4103/1477-3163.146506.

    Article  CAS  Google Scholar 

  6. Chang YL, Tsai YF, Wu YC, Hsieh MJ. Factors relating to quality of life after esophagectomy for cancer patients in Taiwan. Cancer Nurs. 2014;37(1):4–13. https://doi.org/10.1097/NCC.0b013e318277dc53.

    Article  PubMed  Google Scholar 

  7. Sato T, Aoyama T, Hayashi T, Segami K, Kawabe T, Fujikawa H, et al. Impact of preoperative hand grip strength on morbidity following gastric cancer surgery. Gastric Cancer : Off J Int Gastric Cancer Assoc Jpn Gastric Cancer Assoc. 2016;19(3):1008–15. https://doi.org/10.1007/s10120-015-0554-4.

    Article  Google Scholar 

  8. Heneghan HM, Zaborowski A, Fanning M, McHugh A, Doyle S, Moore J, et al. Prospective study of malabsorption and malnutrition after esophageal and gastric cancer surgery. Ann Surg. 2015;262(5):803–7; discussion 7–8. https://doi.org/10.1097/sla.0000000000001445.

    Article  PubMed  Google Scholar 

  9. Chasen MR, Bhargava R. A Rehabilitation program for patients with gastroesophageal cancer—a pilot study. Support Care Cancer: Off J Multinatl Assoc Suppor Care Cancer. 2010;18(Suppl 2):S35–40. https://doi.org/10.1007/s00520-010-0828-7.

    Article  Google Scholar 

  10. Scarpa M, Valente S, Alfieri R, Cagol M, Diamantis G, Ancona E, et al. Systematic review of health-related quality of life after esophagectomy for esophageal cancer. World J Gastroenterol. 2011;17(42):4660–74. https://doi.org/10.3748/wjg.v17.i42.4660.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Forshaw MJ, Strauss DC, Davies AR, Wilson D, Lams B, Pearce A, et al. Is cardiopulmonary exercise testing a useful test before esophagectomy? Ann Thorac Surg. 2008;85(1):294–9. https://doi.org/10.1016/j.athoracsur.2007.05.062.

    Article  PubMed  Google Scholar 

  12. Jack S, West MA, Raw D, Marwood S, Ambler G, Cope TM, et al. The effect of neoadjuvant chemotherapy on physical fitness and survival in patients undergoing oesophagogastric cancer surgery. Eur J Surg Oncol : J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2014;40(10):1313–20. https://doi.org/10.1016/j.ejso.2014.03.010.

    Article  CAS  Google Scholar 

  13. Brach JS. The relation of physical activity to functional status over a seventeen-year time period in community-dwelling older women. PhD Thesis. 2000.

  14. Granger CL, McDonald CF, Parry SM, Oliveira CC, Denehy L. Functional capacity, physical activity and muscle strength assessment of individuals with non-small cell lung cancer: a systematic review of instruments and their measurement properties. BMC Cancer. 2013;13:135. https://doi.org/10.1186/1471-2407-13-135.

    Article  PubMed  PubMed Central  Google Scholar 

  15. van Roekel EH, Bours MJ, de Brouwer CP, Ten Napel H, Sanduleanu S, Beets GL, et al. The applicability of the international classification of functioning, disability, and health to study lifestyle and quality of life of colorectal cancer survivors. Cancer Epidemiol Biomark Prev. 2014;23(7):1394–405. https://doi.org/10.1158/1055-9965.epi-13-1144.

    Article  Google Scholar 

  16. Daster S, Soysal SD, Stoll L, Peterli R, von Flue M, Ackermann C. Long-term quality of life after Ivor Lewis esophagectomy for esophageal cancer. World J Surg. 2014;38(9):2345–51. https://doi.org/10.1007/s00268-014-2576-1.

    Article  PubMed  Google Scholar 

  17. Darling G, Eton DT, Sulman J, Casson AG, Celia D. Validation of the functional assessment of cancer therapy esophageal cancer subscale. Cancer. 2006;107(4):854–63. https://doi.org/10.1002/cncr.22055.

    Article  PubMed  Google Scholar 

  18. Munene G, Francis W, Garland SN, Pelletier G, Mack LA, Bathe OF. The quality of life trajectory of resected gastric cancer. J Surg Oncol. 2012;105(4):337–41. https://doi.org/10.1002/jso.22139.

    Article  PubMed  Google Scholar 

  19. Maas KW, Cuesta MA, van Berge Henegouwen MI, Roig J, Bonavina L, Rosman C, et al. Quality of life and late complications after minimally invasive compared to open esophagectomy: results of a randomized trial. World J Surg. 2015;39(8):1986–93. https://doi.org/10.1007/s00268-015-3100-y.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  20. Malmstrom M, Ivarsson B, Johansson J, Klefsgard R. Long-term experiences after oesophagectomy/gastrectomy for cancer—a focus group study. Int J Nurs Stud. 2013;50(1):44–52. https://doi.org/10.1016/j.ijnurstu.2012.08.011.

    Article  PubMed  Google Scholar 

  21. Thorsen L, Nystad W, Stigum H, Hjermstad M, Oldervoll L, Martinsen EW, et al. Fosså SD Cardiorespiratory fitness in relation to self-reported physical function in cancer patients after chemotherapy. J Sports Med Phys Fit. 2006;46(1):122–7.

    CAS  Google Scholar 

  22. Boyle T, Lynch BM, Courneya KS, Vallance JK. Agreement between accelerometer-assessed and self-reported physical activity and sedentary time in colon cancer survivors. Support Care in Cancer: Off J the Multinatl Assoc Support Care in Cancer. 2015;23(4):1121–6. https://doi.org/10.1007/s00520-014-2453-3.

    Article  Google Scholar 

  23. Steins Bisschop CN, Velthuis MJ, Wittink H, Kuiper K, Takken T, van der Meulen WJ, et al. Cardiopulmonary exercise testing in cancer rehabilitation: a systematic review. Sports Med (Auckland, NZ). 2012;42(5):367–79. https://doi.org/10.2165/11598480-000000000-00000.

    Article  Google Scholar 

  24. Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, Pinto BM, et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc. 2010;42(7):1409–26. https://doi.org/10.1249/MSS.0b013e3181e0c112.

    Article  PubMed  Google Scholar 

  25. Leitzmann M, Powers H, Anderson AS, Scoccianti C, Berrino F, Boutron-Ruault MC et al. European code against cancer 4th edition: physical activity and cancer. Cancer Epidemiol 2015;39 Suppl 1:S46–55 doi:https://doi.org/10.1016/jcanep201503.009.

  26. Moran J, Wilson F, Guinan E, McCormick P, Hussey J, Moriarty J. Role of cardiopulmonary exercise testing as a risk-assessment method in patients undergoing intra-abdominal surgery: a systematic review. Br J Anaesth. 2016;116(2):177–91. https://doi.org/10.1093/bja/aev454.

    Article  PubMed  CAS  Google Scholar 

  27. Schmidt K, Vogt L, Thiel C, Jager E, Banzer W. Validity of the six-minute walk test in cancer patients. Int J Sports Med. 2013;34(7):631–6. https://doi.org/10.1055/s-0032-1323746.

    Article  PubMed  CAS  Google Scholar 

  28. Feeney C, Reynolds JV, Hussey J. Preoperative physical activity levels and postoperative pulmonary complications post-esophagectomy. Dis Esophagus. 2011;24(7):489–94. https://doi.org/10.1111/j.1442-2050.2010.01171.x.

    Article  PubMed  CAS  Google Scholar 

  29. Chen C-H, Ho-Chang, Huang Y-Z, Hung T-T. Hand-grip strength is a simple and effective outcome predictor in esophageal cancer following esophagectomy with reconstruction: a prospective study. J Cardiothorac Surg. 2011;6(1):98. https://doi.org/10.1186/1749-8090-6-98.

    Article  PubMed  PubMed Central  Google Scholar 

  30. Jones LW, Liang Y, Pituskin EN, Battaglini CL, Scott JM, Hornsby WE, et al. Effect of exercise training on peak oxygen consumption in patients with cancer: a meta-analysis. Oncologist. 2011;16(1):112–20. https://doi.org/10.1634/theoncologist.2010-0197.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Xu Y-J, Cheng JC-H, Lee J-M, Huang P-M, Huang G-H, Chen CC-H. A walk-and-eat intervention improves outcomes for patients with esophageal cancer undergoing neoadjuvant chemoradiotherapy. Oncologist. 2015;20(10):1216–22. https://doi.org/10.1634/theoncologist.2015-0178.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  32. Lococo F, Cesario A, Sterzi S, Magrone G, Dall’Armi V, Mattei F, et al. Rationale and clinical benefits of an intensive long-term pulmonary rehabilitation program after oesophagectomy: preliminary report. Multidiscip Respir Med. 2012;7(1):21. https://doi.org/10.1186/2049-6958-7-21.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–9. w64

    Article  PubMed  Google Scholar 

  34. Hayden JA, van der Windt DA, Cartwright JL, Cote P, Bombardier C. Assessing bias in studies of prognostic factors. Ann Intern Med. 2013;158(4):280–6. https://doi.org/10.7326/0003-4819-158-4-201302190-00009.

    Article  PubMed  Google Scholar 

  35. Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928. https://doi.org/10.1136/bmj.d5928.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Sterne, JAC, Higgins J, Reeves BC on behalf of the development group for ACROBAT-NRSI. A Cochrane Risk of Bias Assessment Tool: for Non-Randomized Studies of Interventions (ACROBAT-NRSI), Version 1.0.0. 2014. http://www.riskofbias.info

  37. Inouez Y, Kimura T, Fujita S, Noro H, Nishikawa K, Yumiba T, et al. A new parameter for assessing postoperative recovery of physical activity using an accelerometer. Surg Today. 2003;33(9):645–50. https://doi.org/10.1007/s00595-003-2582-7.

    Article  PubMed  Google Scholar 

  38. Taguchi S, Osugi H, Higashino M, Tokuhara T, Takada N, Takemura M, et al. Comparison of three-field esophagectomy for esophageal cancer incorporating open or thoracoscopic thoracotomy. Surg Endosc. 2003;17(9):1445–50. https://doi.org/10.1007/s00464-002-9232-9.

    Article  PubMed  CAS  Google Scholar 

  39. Fagevik Olsen M, Larsson M, Hammerlid E, Lundell L. Physical function and quality of life after thoracoabdominal oesophageal resection. Results of a follow-up study. Dig Surg. 2005;22(1–2):63–8. https://doi.org/10.1159/000085348.

    Article  PubMed  Google Scholar 

  40. Tatematsu N, Ezoe Y, Tanaka E, Muto M, Sakai Y, Tsuboyama T. Impact of neoadjuvant chemotherapy on physical fitness, physical activity, and health-related quality of life of patients with resectable esophageal cancer. Am J Clin Oncol. 2013;36(1):53–6. https://doi.org/10.1097/COC.0b013e3182354bf4.

    Article  PubMed  CAS  Google Scholar 

  41. Bowrey DJ, Baker M, Halliday V, Thomas AL, Pulikottil-Jacob R, Smith K, et al. A randomised controlled trial of six weeks of home enteral nutrition versus standard care after oesophagectomy or total gastrectomy for cancer: report on a pilot and feasibility study. Trials. 2015;16:531. https://doi.org/10.1186/s13063-015-1053-y.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  42. Lund M, Alexandersson von Döbeln G, Nilsson M, Winter R, Lundell L, Tsai JA, et al. Effects on heart function of neoadjuvant chemotherapy and chemoradiotherapy in patients with cancer in the esophagus or gastroesophageal junction—a prospective cohort pilot study within a randomized clinical trial. Radiat Oncol. 2015;10(1):16. https://doi.org/10.1186/s13014-014-0310-7.

    Article  PubMed  PubMed Central  Google Scholar 

  43. von Dobeln GA, Nilsson M, Adell G, Johnsen G, Hatlevoll I, Tsai J, et al. Pulmonary function and cardiac stress test after multimodality treatment of esophageal cancer. Pract Radiat Oncol. 2016;6(3):e53–9. https://doi.org/10.1016/j.prro.2015.10.015.

    Article  Google Scholar 

  44. Liedman BL, Bennegard K, Olbe LC, Lundell LR. Predictors of postoperative morbidity and mortality after surgery for gastro-oesophageal carcinomas. Eur J Surg = Acta Chirurgica. 1995;161(3):173–80.

    PubMed  CAS  Google Scholar 

  45. Liedman B, Johnsson E, Merke C, Ruth M, Lundell L. Preoperative adjuvant radiochemotherapy may increase the risk in patients undergoing thoracoabdominal esophageal resections. Dig Surg. 2001;18(3):169–75.

    Article  PubMed  CAS  Google Scholar 

  46. Nagamatsu Y, Shima I, Yamana H, Fujita H, Shirouzu K, Ishitake T. Preoperative evaluation of cardiopulmonary reserve with the use of expired gas analysis during exercise testing in patients with squamous cell carcinoma of the thoracic esophagus. J Thorac Cardiovasc Surg. 2001;121(6):1064–8. https://doi.org/10.1067/mtc.2001.113596.

    Article  PubMed  CAS  Google Scholar 

  47. Murray P, Whiting P, Hutchinson SP, Ackroyd R, Stoddard CJ, Billings C. Preoperative shuttle walking testing and outcome after oesophagogastrectomy. Br J Anaesth. 2007;99(6):809–11. https://doi.org/10.1093/bja/aem305.

    Article  PubMed  CAS  Google Scholar 

  48. Rawat S, Kumar G, Puri A, Sharma MK, Kakria A, Kumar P. Correlation of six-minute walk test, pulmonary function test and radiation pneumonitis in the management of carcinoma of oesophagus: a prospective pilot study. J Radiother Pract. 2011;10(3):191–9. https://doi.org/10.1017/S146039691000035X.

    Article  Google Scholar 

  49. Moyes LH, McCaffer CJ, Carter RC, Fullarton GM, Mackay CK, Forshaw MJ. Cardiopulmonary exercise testing as a predictor of complications in oesophagogastric cancer surgery. Ann R Coll Surg Engl. 2013;95(2):125–30. https://doi.org/10.1308/003588413x13511609954897.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  50. van Egmond MA, van der Schaaf M, Klinkenbijl JHG, Engelbert RHH, van Berge Henegouwen MI. Preoperative functional status is not associated with postoperative surgical complications in low risk patients undergoing esophagectomy. Diseases of the Esophagus. 2016:n/a-n/a. doi:https://doi.org/10.1111/dote.12469.

  51. Wang SL, Zhuang CL, Huang DD, Pang WY, Lou N, Chen FF, et al. Sarcopenia adversely impacts postoperative clinical outcomes following gastrectomy in patients with gastric cancer: a prospective study. Ann Surg Oncol. 2016;23(2):556–64. https://doi.org/10.1245/s10434-015-4887-3.

    Article  PubMed  Google Scholar 

  52. Timmerman H, de Groot JF, Hulzebos HJ, de Knikker R, Kerkkamp HEM, van Meeteren NLU. Feasibility and preliminary effectiveness of preoperative therapeutic exercise in patients with cancer: a pragmatic study. Physiother Theory and Pract. 2011;27(2):117–24. https://doi.org/10.3109/09593981003761509.

    Article  CAS  Google Scholar 

  53. Tatematsu N, Hasegawa S, Tanaka E, Sakai Y, Tsuboyama T. Impact of oesophagectomy on physical fitness and health-related quality of life in patients with oesophageal cancer. Eur J Cancer Care. 2013;22(3):308–13. https://doi.org/10.1111/ecc.12030.

    Article  CAS  Google Scholar 

  54. Heldens AF, Bongers BC, de Vos-Geelen J, van Meeteren NL, Lenssen AF. Feasibility and preliminary effectiveness of a physical exercise training program during neoadjuvant chemoradiotherapy in individual patients with rectal cancer prior to major elective surgery. Eur J Surg Oncol : J Eur Soc Surg Oncol Br Assoc Surg Oncol. 2016;42(9):1322–30. https://doi.org/10.1016/j.ejso.2016.03.021.

    Article  CAS  Google Scholar 

  55. Morielli AR, Usmani N, Boule NG, Tankel K, Severin D, Nijjar T, et al. A phase I study examining the feasibility and safety of an aerobic exercise intervention in patients with rectal cancer during and after neoadjuvant chemoradiotherapy. Oncol Nurs Forum. 2016;43(3):352–62. https://doi.org/10.1188/16.onf.352-362.

    Article  PubMed  Google Scholar 

  56. Awad S, Tan BH, Cui H, Bhalla A, Fearon KC, Parsons SL, et al. Marked changes in body composition following neoadjuvant chemotherapy for oesophagogastric cancer. Clin Nutr (Edinburgh, Scotland). 2012;31(1):74–7. https://doi.org/10.1016/j.clnu.2011.08.008.

    Article  Google Scholar 

  57. Yip C, Goh V, Davies A, Gossage J, Mitchell-Hay R, Hynes O, et al. Assessment of sarcopenia and changes in body composition after neoadjuvant chemotherapy and associations with clinical outcomes in oesophageal cancer. Eur Radiol. 2014;24(5):998–1005. https://doi.org/10.1007/s00330-014-3110-4.

    Article  PubMed  Google Scholar 

  58. Mayo NE, Feldman L, Scott S, Zavorsky G, Kim DJ, Charlebois P, et al. Impact of preoperative change in physical function on postoperative recovery: argument supporting prehabilitation for colorectal surgery. Surgery. 2011;150(3):505–14. https://doi.org/10.1016/j.surg.2011.07.045.

    Article  PubMed  Google Scholar 

  59. Silver JK. Cancer prehabilitation and its role in improving health outcomes and reducing health care costs. Semin Oncol Nurs. 2015;31(1):13–30. https://doi.org/10.1016/j.soncn.2014.11.003.

    Article  PubMed  Google Scholar 

  60. West MA, Loughney L, Lythgoe D, Barben CP, Sripadam R, Kemp GJ, et al. Effect of prehabilitation on objectively measured physical fitness after neoadjuvant treatment in preoperative rectal cancer patients: a blinded interventional pilot study. Br J Anaesth. 2015;114(2):244–51. https://doi.org/10.1093/bja/aeu318.

    Article  PubMed  CAS  Google Scholar 

  61. Silver JK, Baima J. Cancer prehabilitation: an opportunity to decrease treatment-related morbidity, increase cancer treatment options, and improve physical and psychological health outcomes. Am J Phys Med Rehabil. 2013;92(8):715–27. https://doi.org/10.1097/PHM.0b013e31829b4afe.

    Article  PubMed  Google Scholar 

  62. Gillis C, Li C, Lee L, Awasthi R, Augustin B, Gamsa A, et al. Prehabilitation versus rehabilitation: a randomized control trial in patients undergoing colorectal resection for cancer. Anesthesiology. 2014;121(5):937–47. https://doi.org/10.1097/ALN.0000000000000393.

    Article  PubMed  Google Scholar 

  63. Valkenet K, Trappenburg JC, Gosselink R, Sosef MN, Willms J, Rosman C, et al. Preoperative inspiratory muscle training to prevent postoperative pulmonary complications in patients undergoing esophageal resection (PREPARE study): study protocol for a randomized controlled trial. Trials. 2014;15:144. https://doi.org/10.1186/1745-6215-15-144.

    Article  PubMed  PubMed Central  Google Scholar 

  64. Geddes EL, O'Brien K, Reid WD, Brooks D, Crowe J. Inspiratory muscle training in adults with chronic obstructive pulmonary disease: an update of a systematic review. Respir Med. 2008;102(12):1715–29. https://doi.org/10.1016/j.rmed.2008.07.005.

    Article  PubMed  Google Scholar 

  65. Findlay JM, Gillies RS, Millo J, Sgromo B, Marshall RE, Maynard ND. Enhanced recovery for esophagectomy: a systematic review and evidence-based guidelines. Ann Surg. 2014;259(3):413–31. https://doi.org/10.1097/sla.0000000000000349.

    Article  PubMed  Google Scholar 

  66. Markar SR, Karthikesalingam A, Low DE. Enhanced recovery pathways lead to an improvement in postoperative outcomes following esophagectomy: systematic review and pooled analysis. Dis Esophagus : Off J Int Soc Dis Esophagus. 2015;28(5):468–75. https://doi.org/10.1111/dote.12214.

    Article  CAS  Google Scholar 

  67. Mortensen K, Nilsson M, Slim K, Schafer M, Mariette C, Braga M, et al. Consensus guidelines for enhanced recovery after gastrectomy: Enhanced Recovery After Surgery (ERAS(R)) Society recommendations. Br J Surg. 2014;101(10):1209–29. https://doi.org/10.1002/bjs.9582.

    Article  PubMed  CAS  Google Scholar 

  68. Miller KR, Bozeman MC. Nutrition therapy issues in esophageal cancer. Curr Gastroenterol Rep. 2012;14(4):356–66. https://doi.org/10.1007/s11894-012-0272-6.

    Article  PubMed  Google Scholar 

  69. Gannon J, Guinan E, Doyle SL, Beddy P, Reynolds J, Hussey J. Reduced fitness and physical functioning are long-term sequalae after curative treatment for esophageal cancer; a matched control study. Dis Esophagus. 2017;30:1, 7. https://doi.org/10.1093/dote/dox018.

    Article  Google Scholar 

  70. Pekmezi DW, Demark-Wahnefried W. Updated evidence in support of diet and exercise interventions in cancer survivors. Acta Oncologica (Stockholm, Sweden). 2011;50(2):167–78. https://doi.org/10.3109/0284186X.2010.529822.

    Article  Google Scholar 

  71. Guinan EM, Doyle SL, O'Neill L, Dunne MR, Foley EK, O'Sullivan J, et al. Effects of a multimodal rehabilitation programme on inflammation and oxidative stress in oesophageal cancer survivors: the ReStOre feasibility study. Support Care in Cancer: Off J Multinatl Assoc Support Care in Cancer. 2017;25(3):749–56. https://doi.org/10.1007/s00520-016-3455-0.

    Article  Google Scholar 

  72. O'Neill L, Guinan E, Doyle S, Elliot J, O'Sullivan J, Reynolds JV, et al. Rehabilitation strategies following esophageal cancer (the ReStOre trial); a feasibility study. Dis Esophagus. 2017;30(5):1–8. https://doi.org/10.1093/dote/dow012.

    Article  PubMed Central  Google Scholar 

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Acknowledgements

We would like to thank Mr. David Mockler (John Stearne Library, Trinity College Dublin) for his assistance in preparation of the search strategy for this systematic review.

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Authors and Affiliations

  1. Discipline of Physiotherapy, Trinity College Dublin, Dublin, Ireland

    Linda O’Neill, Jonathan Moran & Juliette Hussey

  2. School of Medicine, Trinity College Dublin, Dublin, Ireland

    Emer M. Guinan

  3. Trinity Translational Medicine Institute, Department of Surgery, Trinity College Dublin and St. James’s Hospital, Dublin 8, Ireland

    John V. Reynolds

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  1. Linda O’Neill
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Correspondence to Linda O’Neill.

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O’Neill, L., Moran, J., Guinan, E.M. et al. Physical decline and its implications in the management of oesophageal and gastric cancer: a systematic review. J Cancer Surviv 12, 601–618 (2018). https://doi.org/10.1007/s11764-018-0696-6

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