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High Density Lipoprotein Level is Negatively Associated With the Increase of Oxidized Low Density Lipoprotein Lipids After a Fatty Meal

  • Original Article
  • Published:
Lipids

Abstract

Recent reports show that a fatty meal can substantially increase the concentration of oxidized lipids in low density lipoprotein (LDL). Knowing the LDL-specific antioxidant effects of high density lipoprotein (HDL), we aimed to investigate whether HDL can modify the postprandial oxidative stress after a fatty meal. Subjects of the study (n = 71) consumed a test meal (a standard hamburger meal) rich in lipid peroxides, and blood samples were taken before, 120, 240, and 360 min after the meal. The study subjects were divided into four subgroups according to the pre-meal HDL cholesterol value (HDL subgroup 1, 0.66–0.91; subgroup 2, 0.93–1.13; subgroup 3, 1.16–1.35; subgroup 4, 1.40–2.65 mmol/L). The test meal induced a marked postprandial increase in the concentration of oxidized LDL lipids in all four subgroups. The pre-meal HDL level was associated with the extent of the postprandial rise in oxidized LDL lipids. From baseline to 6 h after the meal, the concentration of ox-LDL increased by 48, 31, 24, and 16 % in the HDL subgroup 1, 2, 3, and 4, respectively, and the increase was higher in subgroup 1 compared to subgroup 3 (p = 0.028) and subgroup 4 (p = 0.0081), respectively. The pre-meal HDL correlated with both the amount and the rate of increase of oxidized LDL lipids. Results of the present study show that HDL is associated with the postprandial appearance of lipid peroxides in LDL. It is therefore likely that the sequestration and transport of atherogenic lipid peroxides is another significant mechanism contributing to cardioprotection by HDL.

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Abbreviations

apo A-1:

Apolipoprotein A-1

BMI:

Body mass index

CV:

Coefficient of variation

CVD:

Cardiovascular diseases

HDL:

High density lipoprotein

HPLC:

High-performance liquid chromatography

LDL:

Low density lipoprotein

MS:

Mass spectrometry

SPSS:

Statistical Package for Social Sciences

TAG:

Triacylglycerol

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Author information

Authors and Affiliations

  1. Department of Health and Exercise and Paavo Nurmi Center, University of Turku, Turku, Finland

    Sanna Tiainen & Petteri Ylinen

  2. Department of Sports and Exercise Medicine, Sports Institute of Finland, 19120, Vierumäki, Finland

    Sanna Tiainen

  3. MCA Research Laboratory, Department of Physiology, University of Turku, Turku, Finland

    Markku Ahotupa

  4. UKK Institute for Health Promotion Research, Tampere, Finland

    Tommi Vasankari

Authors
  1. Sanna Tiainen
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  2. Markku Ahotupa
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  3. Petteri Ylinen
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  4. Tommi Vasankari
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Correspondence to Sanna Tiainen.

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Tiainen, S., Ahotupa, M., Ylinen, P. et al. High Density Lipoprotein Level is Negatively Associated With the Increase of Oxidized Low Density Lipoprotein Lipids After a Fatty Meal. Lipids 49, 1225–1232 (2014). https://doi.org/10.1007/s11745-014-3963-y

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  • DOI: https://doi.org/10.1007/s11745-014-3963-y

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