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Short Term Dietary Fish Oil Supplementation Improves Motor Deficiencies Related to Reserpine-Induced Parkinsonism in Rats

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Lipids

Abstract

Fish oil (FO) supplementation could cause an increase in the concentration of plasmatic free fatty acids and, consequently, could compete with pro-inflammatory arachidonic acid (ARA) derived from brain biomembranes metabolism in the cerebrospinal fluid. Essential fatty acids (EFA) (n-3) have been reported by their antioxidant and neuroprotective properties, and therefore the influence of the FO supplementation on the reserpine-induced motor disorders was studied. Wistar rats were orally treated with FO solution for 5 days, and co-treated with reserpine (R; 1 mg/kg/mL) or its vehicle for 3 days (every other day). Reserpine-induced orofacial dyskinesia and catalepsy (P < 0.05) were prevented by FO (P < 0.05). Biochemical evaluations showed that reserpine treatment increased the lipid peroxidation in the cortex and striatum (P < 0.05), while the FO supplementation prevented this oxidative effect in both brain regions (P < 0.05). Our results showed the protective role of FO in the brain lipid membranes, reinforcing the beneficial effect of n-3 fatty acids in the prevention of degenerative and motor disorders.

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Abbreviations

ALA:

α-Linolenic acid

ARA:

Arachidonic acid

DA:

Dopamine

DHA:

Docosahexaenoic acid

DPA:

Docosapentaenoic acid

EFA:

Essential fatty acid(s)

EPA:

Eicosapentaenoic acid

FO:

Fish oil

FT:

Facial twitching

LNA:

Linoleic acid

MAO:

Monoamine oxidase

NF-κB:

Nuclear factor kappa-light-chain-enhancer of activated B cells

PUFA:

Polyunsaturated fatty acids

SO:

Soybean oil

TBARS:

Thiobarbituric acid reactive substances

VCM:

Vacuous chewing movements

VMAT:

Vesicular monoamine transporter

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The authors report no conflicts of interest.

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Authors and Affiliations

  1. Departamento de Fisiologia e Farmacologia, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil

    Nardeli Boufleur & Camila Pase

  2. Programa de Pós-Graduação em Farmacologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil

    Raquel Cristine Silva Barcelos, Dalila Moter Benvegnú, Angélica Martelli Teixeira, Patrícia Reckziegel, Tatiana Emanuelli & Marilise Escobar Bürger

  3. Programa de Pós-Graduação em Bioquímica Toxicológica, UFSM, Santa Maria, RS, Brazil

    Tatiana Emanuelli, João Batista T. da Rocha & Marilise Escobar Bürger

  4. Programa de Pós Graduação em Ciência e Tecnologia dos Alimentos, Centro de ciências Rurais, UFSM, Santa Maria, Brazil

    Tatiana Emanuelli

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  1. Raquel Cristine Silva Barcelos
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  2. Dalila Moter Benvegnú
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Correspondence to Marilise Escobar Bürger.

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Barcelos, R.C.S., Benvegnú, D.M., Boufleur, N. et al. Short Term Dietary Fish Oil Supplementation Improves Motor Deficiencies Related to Reserpine-Induced Parkinsonism in Rats. Lipids 46, 143–149 (2011). https://doi.org/10.1007/s11745-010-3514-0

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