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Effects of ω-3 Essential Fatty Acids (ω-3 EFAs) on Motor Disorders and Memory Dysfunction Typical Neuroleptic-induced: Behavioral and Biochemical Parameter

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Abstract

The effects of fish oil supplementation on motor disorders, memory dysfunction, and lipid peroxidation (LP) induced by typical neuroleptics were studied. Wistar rats received a suspension prepared with fish oil containing ω-3 fatty acids, water, and Tween 80 (1%) in the place of drinking water (FO group) or vehicle (C group) for 8 weeks. After 4 weeks of treatment, half of the animals of both groups were treated with haloperidol (H and FO + H groups; experiment 1), fluphenazine (F and FO + F groups; experiment 2), or vehicle (C group), administered once a week (12 mg/kg/im) for 4 weeks, maintaining the treatment with FO. Extrapyramidal motor disorders by haloperidol and fluphenazine were observed by an increase in vacuous chewing movements and catalepsy (P < 0.05). These effects were reduced by FO treatment (P < 0.05). Both neuroleptics displayed impairment in memory retention observed by latency time to find the original location of platform in water-maze task, after 4 days of training performed in the last treatment week. This effect was reduced by FO (P < 0.05) to both haloperidol and fluphenazine treatments. Haloperidol increased the LP in plasma and hippocampus, and these effects were decreased by FO treatment (P < 0.05). Fluphenazine increased the LP in plasma and substantia nigra, which were completely decreased by FO treatment (P < 0.05). The FO decreased the motor disorders, memory dysfunction, and oxidative damage typical neuroleptic-induced. Our results indicate that FO exhibits a neuroprotector role useful on diseases related to oxidative damages, and may be considered in the prevention of motor and memory side effects induced by the antipsychotic treatment.

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Authors and Affiliations

  1. Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria , RS, Brazil

    Raquel Cristine Silva Barcelos & Dalila Moter Benvegnú

  2. Departamento de Fisiologia e Farmacologia, CCS, Universidade Federal de Santa Maria, 97105-900, Santa Maria, RS, Brazil

    Nardeli Boufleur, Patrícia Reckziegel, Liz Girardi Müller, Camila Pase & Marilise Escobar Bürger

  3. Departamento de ciência e Tecnologia de alimentos, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil

    Tatiana Emanuelli

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  1. Raquel Cristine Silva Barcelos
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Barcelos, R.C.S., Benvegnú, D.M., Boufleur, N. et al. Effects of ω-3 Essential Fatty Acids (ω-3 EFAs) on Motor Disorders and Memory Dysfunction Typical Neuroleptic-induced: Behavioral and Biochemical Parameter. Neurotox Res 17, 228–237 (2010). https://doi.org/10.1007/s12640-009-9095-0

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