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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

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Abstract

Sensory hair cells in the inner ear are responsible for sound recognition. Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannot regenerate. By contrast, newborn mammals possess limited regenerative capacity because of the active participation of various signaling pathways, including Wnt and Notch signaling. The Wnt and Notch pathways are highly sophisticated and conserved signaling pathways that control multiple cellular events necessary for the formation of sensory hair cells. Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochlea. In this regard, Wnt and Notch signaling has gained increased research attention in hair cell regeneration. This review presents the current understanding of the Wnt and Notch signaling pathways in the auditory portion of the inner ear and discusses the possibilities of controlling these pathways with the hair cell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.

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Authors and Affiliations

  1. Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, 210096, China

    Muhammad Waqas, Shasha Zhang, Zuhong He, Mingliang Tang & Renjie Chai

  2. Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China

    Muhammad Waqas, Shasha Zhang, Zuhong He, Mingliang Tang & Renjie Chai

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  1. Muhammad Waqas
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  2. Shasha Zhang
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  3. Zuhong He
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  4. Mingliang Tang
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  5. Renjie Chai
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Correspondence to Mingliang Tang or Renjie Chai.

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These authors contributed equally to this work.

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Waqas, M., Zhang, S., He, Z. et al. Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea. Front. Med. 10, 237–249 (2016). https://doi.org/10.1007/s11684-016-0464-9

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  • DOI: https://doi.org/10.1007/s11684-016-0464-9

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