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Antibacterial Cu-Doped HA/TiO2 Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti

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Abstract

Cu-doped hydroxyapatite (HA)/TiO2 (CuHA/TiO2) bioactive ceramic composite coatings were prepared on Ti surfaces using an electrochemical method to enhance their adhesion and antibacterial properties. The obtained coatings were characterized by scanning electron microscopy, x-ray diffraction, and x-ray photoelectron spectroscopy, while their adhesion was measured using a scratch test. The maximum adhesion between the TiO2 layer and the substrate was 39.8 ± 2.6 N at an anodizing voltage of 180 V. Subsequently, the CuHA coatings were successfully deposited on the TiO2 layers and grown outward along TiO2 pores (during this process, Cu atoms are doped into the HA structure in the form of Cu2+ ions). The CuHA adhesion to the TiO2 layer was 26.3 ± 1.9 N, indicating that the TiO2 interlayer significantly enhanced the bonding of CuHA to the substrate. Furthermore, the fabricated CuHA/TiO2 coatings produced a strong antibacterial effect on Escherichia coli and Staphylococcus aureus species, exhibited high biocompatibility, and promoted the proliferation of MC3T3-E1 cells.

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Acknowledgments

This work was partially supported by the Natural Science Foundation of Shanghai, China (No. 15ZR1428400), Shanghai Engineering Research Center of High-Performance Medical Device Materials (No. 20DZ2255500), and the Grant-in Aid for Scientific Research (C) (No. 20K05139) from JSPS (Japan Society for the Promotion of Science), Tokyo, Japan.

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Authors and Affiliations

  1. School of Mechanical Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, People’s Republic of China

    Jiawei Yang, Qiang Li, Jinshuai Yang, Ran Zhang & Mitsuo Niinomi

  2. Shanghai Engineering Research Center of High-Performance Medical Device Materials, Shanghai, 200093, People’s Republic of China

    Qiang Li

  3. CAS Key Laboratory of Functional Materials and Devices for Special Environments, Xinjiang Technical Institute of Physics and Chemistry, CAS, Xinjiang Key Laboratory of Electronic Information Materials and Devices, 40-1 South Beijing Road, Urumqi, 830011, People’s Republic of China

    Junjie Li

  4. Institute for Materials Research, Tohoku University, 2-1-1, Katahira, Aoba-Ku, Sendai, 980-8577, Japan

    Mitsuo Niinomi

  5. Division of Materials and Manufacturing Science, Graduate School of Engineering, Osaka University, 2-1, Yamada-Oka, Suita, Osaka, 565-0871, Japan

    Mitsuo Niinomi & Takayoshi Nakano

  6. Department of Materials Science and Engineering, Graduate School of Science and Technology, Meijo University, 1-501, Shiogamaguchi, Tempaku-Ku, Nagoya, 468-8502, Japan

    Mitsuo Niinomi

  7. Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, 564-8680, Japan

    Mitsuo Niinomi

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  1. Jiawei Yang
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Yang, J., Li, Q., Li, J. et al. Antibacterial Cu-Doped HA/TiO2 Bioactive Ceramic Composite Coating with Enhanced Adhesion on Pure Ti. J. of Materi Eng and Perform 32, 6151–6159 (2023). https://doi.org/10.1007/s11665-022-07541-6

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