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Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart Failure Rats via Inhibiting P38 MAPK Pathway

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Summary

Paeoniforin (Pae) is a monoterpenoid glycoside compound and has many biological activities, such as immunosuppression, anti-inflammation and anti-cell proliferation. However, the effects and mechanisms of Pae on chronic heart failure (CHF) remain unclear. This study was conducted to assess the effects and mechanisms of Pae on myocardial fbrosis in isoprenaline (Iso)-induced CHF rats. Pae (20 mg/kg) was intragastrically administrated to CHF rats for 6 weeks. Cardiac structure and function were assessed. The protein and mRNA levels of transforming growth factor β1 (TGF-β1) and p38 were detected. Compared to Iso group, Pae could alleviate myocardial fibrosis and improve cardiac function in CHF rats. The levels of collagen volume fraction (13.75%±3.77% vs. 30.97%±4.22%, P<0.001) and perivascular collagen volume area (14.32%±2.50% vs. 28.31%±3.16%, P<0.001) were signifcantly reduced in Pae group as compared with those in Iso group. The expression of TGF-β1 protein (0.30±0.07 vs. 0.66±0.07, P<0.05) and mRNA (3.51±0.44 vs. 7.58±0.58, P<0.05) decreased signifcantly in Pae group as compared with that in Iso group. The expression of p38 protein (0.36±0.12 vs. 0.81±0.38, P<0.05) and mRNA (3.84±0.05 vs. 4.40±0.17, P<0.05) also decreased markedly in Pae group as compared with that in Iso group. Pae could attenuate myocardial fbrosis and improve cardiac function in CHF rats by down-regulating the p38 MAPK signaling pathway.

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Authors and Affiliations

  1. Department of Cardiology, Cardiovascular Research Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China

    Mao Liu, Jie Feng, Qian Du, Jiao Ai & Zhan Lv

  2. Department of Clinical Medicine, North Sichuan Medical College, Nanchong, 637000, China

    Mao Liu, Jie Feng, Jiao Ai & Zhan Lv

Authors
  1. Mao Liu
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  2. Jie Feng
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  3. Qian Du
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  4. Jiao Ai
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  5. Zhan Lv
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Correspondence to Mao Liu.

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The authors report no conflicts of interest in this work.

Additional information

This study was supported by grants from Scientific Research Development Program of North Sichuan Medical College (No. CBY16-A-ZD10) and Nanchong Government-University Strategic Cooperation Project in Science and Technology (No. 18SXHZ0505).

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Liu, M., Feng, J., Du, Q. et al. Paeoniflorin Attenuates Myocardial Fibrosis in Isoprenaline-induced Chronic Heart Failure Rats via Inhibiting P38 MAPK Pathway. CURR MED SCI 40, 307–312 (2020). https://doi.org/10.1007/s11596-020-2178-0

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  • DOI: https://doi.org/10.1007/s11596-020-2178-0

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