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Relationship between visceral adipose tissue and genetic mutations (VHL and KDM5C) in clear cell renal cell carcinoma

  • Abdominal Radiology
  • Published:
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Abstract

Background

The sequencing of the renal cell carcinoma (RCC) genome has detected several mutations with prognostic meaning. The association between visceral adipose tissue (VAT) and clear cell renal cell carcinoma (ccRCC) is well known. The relationship among abdominal adipose tissue distribution and ccRCC-VHL and KDM5C genetic mutations is, to the knowledge of the authors, not known.

Methods

In this retrospective study, we enrolled 97 Caucasian male patients divided into three groups: the control group (n = 35), the ccRCC-VHL group (n = 52) composed of ccRCC patients with VHL mutations and ccRCC-KDM5C group (n = 10) composed of ccRCC patients with KDM5C mutation. Total adipose tissue (TAT) area, VAT area and subcutaneous adipose tissue (SAT) area were measured in the groups. VAT/SAT ratio was calculated for each subject.

Results

Statistically significant differences between ccRCC-KDM5C group and ccRCC-VHL group were obtained for TAT area (p < 0.05), VAT area (p < 0.05) and VAT/SAT ratio (p < 0.05); between ccRCC-VHL group and control group for TAT area (p < 0.001) and VAT area (p < 0.01); and between ccRCC-KDM5C group and control group for TAT area (p < 0.0001), VAT area (p < 0.0001) and SAT area (p < 0.01).

Conclusions

This study demonstrates for the first time an increased amount of TAT, especially VAT, in the ccRCC-VHL and ccRCC-KDM5C groups. The effect was greater for the ccRCC-KDM5C group.

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Authors and Affiliations

  1. U.O.C. Diagnostica per Immagini Territoriale Aziendale, Cittadella della Salute Azienda Sanitaria Locale di Lecce, Piazza Filippo Bottazzi, 73100, Lecce, Italy

    Federico Greco

  2. Unit of Diagnostic Imaging, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy

    Carlo Augusto Mallio

Authors
  1. Federico Greco
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  2. Carlo Augusto Mallio
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Contributions

All authors contributed to the study conception and design. FG, CAM helped in conception and design, definition of intellectual content, literature search, clinical studies, experimental studies, data analysis, statistical analysis. FG contributed to data acquisition, manuscript preparation. CAM was involved in manuscript editing and manuscript review. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Federico Greco.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical standards

Institutional review board was not required because this is an observational retrospective study, and only existing information collected from human participants are used, and there are not any identifiers linking individual to the data. This article does not contain any studies with animals performed by any of the authors.

Informed consent

The study was performed in accordance with the Declaration of Helsinki. The institutional ethical committee approved the study. All subjects enrolled provided a written informed consent to use their anonymized data for research purposes.

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Greco, F., Mallio, C.A. Relationship between visceral adipose tissue and genetic mutations (VHL and KDM5C) in clear cell renal cell carcinoma. Radiol med 126, 645–651 (2021). https://doi.org/10.1007/s11547-020-01310-y

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  • DOI: https://doi.org/10.1007/s11547-020-01310-y

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