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Increased visceral adipose tissue in male patients with non-clear cell renal cell carcinoma

  • ABDOMINAL RADIOLOGY
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Abstract

Background

It is well known that there is a link between obesity and oncogenesis in many sites, including the kidney. Adiposopathy is characterized by an excessive accumulation of adipose tissue, principally visceral, which can lead to adipocyte and adipose tissue-related disorder, promoting metabolic syndrome. Visceral adipocytes secrete growth factors, proinflammatory cytokines and adipokines, regarded as mediating factors associated with the oncogenesis of obesity-related tumors. In this study, we evaluate the relationship between visceral adipose tissue (VAT) and non-clear cell renal cell carcinoma (nccRCC) in male patients.

Methods

In this retrospective study, two groups were included: nccRCC group and control group. Total adipose tissue (TAT) area, VAT area and subcutaneous adipose tissue (SAT) area were measured in both groups. VAT/SAT ratio was subsequently calculated.

Results

Statistically significant differences between the two groups were found in TAT area (p = 0.05), VAT area (p < 0.01) and VAT/SAT ratio (p < 0.05), while no significant difference was found in SAT area.

Conclusions

This study demonstrates an increased visceral adipose tissue in male patients with nccRCC.

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Author information

Authors and Affiliations

  1. U.O.C. Diagnostica per Immagini Territoriale Aziendale, Cittadella della Salute Azienda Sanitaria Locale di Lecce, Piazza Filippo Bottazzi, 73100, Lecce, Italy

    Federico Greco & Luigi Giuseppe Quarta

  2. Unit of Diagnostic Imaging, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy

    Carlo Augusto Mallio, Raffaele Grippo, Laura Messina, Rosario Francesco Grasso & Bruno Beomonte Zobel

  3. Pathology Unit, Università Campus Bio-Medico di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy

    Silvia Vallese & Carla Rabitti

Authors
  1. Federico Greco
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  2. Carlo Augusto Mallio
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  3. Raffaele Grippo
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  4. Laura Messina
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  5. Silvia Vallese
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  6. Carla Rabitti
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  7. Luigi Giuseppe Quarta
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  8. Rosario Francesco Grasso
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  9. Bruno Beomonte Zobel
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Contributions

All authors contributed to the study conception and design. FG conceived and designed the study, carried out statistical analysis, and prepared the manuscript. FG, BBZ, RFG and LGQ defined the intellectual content. CAM and FG performed the literature search. CAM, BBZ and RFG carried out clinical studies. FG and CAM conducted experimental studies. RG, LM and SV took part in data acquisition. FG and CAM analyzed the data. BBZ, RFG, CAM, LGQ and CR edited and reviewed the manuscript. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Federico Greco.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Approval from the Institutional Review Board was not required because this is an observational retrospective study; only existing information collected from human participants is used; and there are not any identifiers linking individual to the data.

Ethical standards

This article does not contain any studies with animals performed by any of the authors. The study was performed in accordance with the Declaration of Helsinki. The Institutional Ethical Committee approved the study. All subjects enrolled provided a written informed consent to use their anonymized data for research purposes.

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Greco, F., Mallio, C.A., Grippo, R. et al. Increased visceral adipose tissue in male patients with non-clear cell renal cell carcinoma. Radiol med 125, 538–543 (2020). https://doi.org/10.1007/s11547-020-01146-6

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  • DOI: https://doi.org/10.1007/s11547-020-01146-6

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