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IRF4 and IRF8: governing the virtues of B lymphocytes

  • Review
  • Published:
Frontiers in Biology

Abstract

Interferon regulatory factor 4 (IRF4) and IRF8 are critical regulators of immune system development and function. In B lymphocytes, IRF4 and IRF8 have been shown to control important events during their development and maturation including pre-B cell differentiation, induction of B cell tolerance pathways, marginal zone B cell development, germinal center reaction and plasma cell differentiation. Mechanistically, IRF4 and IRF8 are found to function redundantly to control certain stages of B cell development, but in other stages, they function nonredundantly to play distinct roles in B cell biology. In line with their essential roles in B cell development, deregulated expressions of IRF4 and IRF8 have been associated to the pathogenesis of several B cell malignancies and diseases. Recent studies have elucidated diverse transcriptional networks regulated by IRF4 and IRF8 at distinct B cell developmental stages and related malignancies. In this review we will discuss the recent advances for the roles of IRF4 and IRF8 during B cell development and associated diseases.

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  1. Department of Genetics, Cell Biology & Anatomy, University of Nebraska Medical Center, Omaha, NE, 68198, USA

    Vipul Shukla & Runqing Lu

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Shukla, V., Lu, R. IRF4 and IRF8: governing the virtues of B lymphocytes. Front. Biol. 9, 269–282 (2014). https://doi.org/10.1007/s11515-014-1318-y

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