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Progress in the development of techniques based on light scattering for single nanoparticle detection

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Abstract

Nanoparticles have recently attracted extensive attention in view of their great potential in biomedicine and bioanalytical applications. Single particle detection via light scattering offers a simple and efficient approach for the size, size distribution, and concentration analysis of nanoparticles. In particular, intrinsic heterogeneity or rare events masked by ensemble averaging can be revealed. However, the sixth power dependence of Rayleigh scattering on particle size makes it very challenging to detect individual nanoparticles of small sizes. This article is intended to provide an overview of recent progress in the development of techniques based on light scattering for the detection of single nanoparticles.

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  1. Department of Chemical Biology, College of Chemistry and Chemical Engineering; Key Laboratory for Chemical Biology of Fujian Province; Key Laboratory of Analytical Science, Xiamen University, Xiamen, 361005, China

    ShaoBin Zhu, Shuo Wang, LingLing Yang, TianXun Huang & XiaoMei Yan

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  1. ShaoBin Zhu
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Zhu, S., Wang, S., Yang, L. et al. Progress in the development of techniques based on light scattering for single nanoparticle detection. Sci. China Chem. 54, 1244–1253 (2011). https://doi.org/10.1007/s11426-011-4313-z

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