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Role of heat shock proteins in aging and chronic inflammatory diseases

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Abstract

Advanced age is associated with a decline in response to stress. This contributes to the establishment of chronic inflammation, one of the hallmarks of aging and age-related disease. Heat shock proteins (HSP) are determinants of life span, and their progressive malfunction leads to age-related pathology. To discuss the function of HSP on age-related chronic inflammation and illness. An updated review of literature and discussion of relevant work on the topic of HSP in normal aging and chronic inflammatory pathology was performed. HSP contribute to inflamm-aging. They also play a key role in age-associated pathology linked to chronic inflammation such as autoimmune disorders, neurological disease, cardiovascular disorder, and cancer. HSP may be targeted for control of their effects related to age and chronic inflammation. Research on HSP functions in age-linked chronic inflammatory disorders provides an opportunity to improve health span and delay age-related chronic disorders.

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Abbreviations

AD:

Alzheimer’s disease

CVD:

Cardiovascular disease

DAMP:

Danger-associated molecular pattern

HSF1:

Heat shock transcription factor

HSP:

Heat shock proteins

HSPB5:

αB-crystallin

IL:

Interleukin

MS:

Multiple sclerosis

NF-κB:

Nuclear factor kappa-light-chain-enhancer of activated B cells

PD:

Parkinson’s disease

ROS:

Reactive oxygen species

SASP:

Senescence-associated secretory phenotype

STAT3:

Signal transducer and activator of transcription 3

TLR:

Toll-like receptors

TME:

Tumor microenvironment

TNF:

Tumor necrosis factor

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Acknowledgements

The author thanks Drs. Venkat Mannam, Ingrid Espinoza, Amit Reddy, and Ms. Isabella Gomez-Espinoza for valuable discussions and critical reading of the manuscript.

Funding

This study was supported in part by Grant DOD PC094680 and PCF Creativity Award.

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Author notes

  1. Christian R. Gomez

    Present address: Division of Lung Diseases, National Institutes of Health (NIH), National Heart, Lung and Blood Institute (NHLBI), Bethesda, MD, USA

Authors and Affiliations

  1. Department of Pathology, University of Mississippi Medical Cent, er, 2500 N. State St, Jackson, MS, 39216, USA

    Christian R. Gomez

  2. Department of Radiation Oncology, University of Mississippi Medical Center, 2500 N. State St, Jackson, MS, 39216, USA

    Christian R. Gomez

  3. Preclinical Research Unit, Center for Clinical and Translational Science, University of Mississippi, 2500 N. State St, Jackson, MS, 39216, USA

    Christian R. Gomez

  4. Cancer Center and Research Institute, University of Mississippi Medical Center, 2500 N. State St, Jackson, MS, 39216, USA

    Christian R. Gomez

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  1. Christian R. Gomez
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CRG had the idea for the article, performed the literature search and data analysis, and drafted the work.

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Correspondence to Christian R. Gomez.

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Dr. Gomez contributed to this article as an employee of the University of Mississippi Medical Center. The views expressed are his own and do not necessarily represent the views of the National Institutes of Health or the US Government.

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Gomez, C.R. Role of heat shock proteins in aging and chronic inflammatory diseases. GeroScience 43, 2515–2532 (2021). https://doi.org/10.1007/s11357-021-00394-2

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