Abstract
Cisplatin, an anticancer drug used in treating various types of cancers, can cause reproductive toxicities during chemotherapy. Keeping this in view, the present study was designed to investigate the possible protective effects of normal vitamin C and E and vitamin C and E nanoparticles (embedded in chitosan) against cisplatin-induced reproductive toxicities. Vitamins C, E, and their nanoparticles in this regard proved to be an effective therapy. The work aimed to treat cisplatin-induced reproductive toxicities through vitamin C and E and their nanoparticles. Cisplatin exposure caused significant reduction in the weight, testosterone level, and changed lipid profile. Similarly, cisplatin induced significant widespread testicular atrophy and testicular lesions as evidenced by the gaps in the epithelium and loss of differentiating germ cells. Vitamin C and E and their nanoparticles rescued the weight, testosterone level, and testicular disturbances, which is associated with improved histological view of testicular tissues. The current study highlights evidence that designing a medication of vitamin C and E nanoparticles is useful in mitigating cisplatin-induced reproductive toxicity in cancerous male patients underlying chemotherapy.
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Acknowledgements
We thank Dr. Junfen Fu, Dr. Sarwat Jahan, Ms. Ayesha Nawaz, Mr. Hizb Ullah, Mr. Rahim Ullah, and all other colleagues for financial, technical, and moral support in conducting this experiment.
Funding
This work was supported by the National Key Research and Development Programme of China (No. 2016YFC1305301), National Natural Science Foundation of China (Nos. 81570759 and 81270938), and Zhejiang Provincial Key Disciplines of Medicine (Innovation discipline, 11-CX24) and in part by Higher Education Commission (HEC) of Pakistan.
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Sarwat Jahan led the design. Naveed Rauf conceived the study and performed the experimental work with the help of Ayesha Nawaz. Ayesha Nawaz also helped in compiling the results. Hizb Ullah contributed in literature review. Rahim Ullah helped in reviewing the paper. Asad Ullah played his role in biochemical analysis. Ghulam Nabi checked the paper for English correction. Fazal Wahab also contributed in reviewing the article. Junfen Fu reviewed the manuscript and provided funding. At the end, Naveed Rauf and Ayesha Nawaz wrote the paper with input from all other authors. All authors read and approved the final manuscript.
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Rauf, N., Nawaz, A., Ullah, H. et al. Therapeutic effects of chitosan-embedded vitamin C, E nanoparticles against cisplatin-induced gametogenic and androgenic toxicity in adult male rats. Environ Sci Pollut Res 28, 56319–56332 (2021). https://doi.org/10.1007/s11356-021-14516-y
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DOI: https://doi.org/10.1007/s11356-021-14516-y