Abstract
Colorectal cancer (CRC) is a highly prevalent gastrointestinal cancer worldwide. Recent research has shown that the gut microbiota plays a significant role in the development of CRC. There is mounting evidence supporting the crucial contributions of bacteria-derived toxins and metabolites to cancer-related inflammation, immune imbalances, and the response to therapy. Besides, some gut microbiota and microbiota-derived metabolites have protective effects against CRC. This review aims to summarize the current studies on the effects and mechanisms of gut microbiota and microbiota-produced metabolites in the initiation, progression, and drug sensitivity/resistance of CRC. Additionally, we explore the clinical implications and future prospects of utilizing gut microbiota as innovative approaches for preventing and treating CRC.
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This work was supported by the National Natural Science Foundation, China [82003042, 82201925] and Natural Science Foundation, Shandong Province [ZR2019QH012, ZR2022QH203].
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Xinyi Wang prepared and wrote the original draft; Xicai Sun, Jinjin Chu, Wenchang Sun, Shushan Yan and Yaowen Wang reviewed and edited the manuscript. All authors read and approved the final manuscript.
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Wang, X., Sun, X., Chu, J. et al. Gut microbiota and microbiota-derived metabolites in colorectal cancer: enemy or friend. World J Microbiol Biotechnol 39, 291 (2023). https://doi.org/10.1007/s11274-023-03742-w
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DOI: https://doi.org/10.1007/s11274-023-03742-w