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Synthesis, characterization, DNA binding and cleavage properties of a ternary copper(II) Schiff base complex

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Abstract

A ternary coordination complex 2Cu(C14H8NO3Cl)(C12H8N2)·3CH3OH of a Schiff base (C14H8NO3Cl: 4-chloroanthranilic acid–salicylaldehyde) was synthesized from 4-chloroanthranilic acid, salicylaldehyde, copper acetate and 1,10-phenanthroline and characterized by physicochemical and spectroscopic methods. X-ray crystallography shows that the copper atom is five coordinated by the imine nitrogen, two nitrogen atoms from 1,10-phenanthroline, the hydroxyl oxygen and the carboxylate oxygen atom. The interaction of the complex with calf-thymus DNA was investigated by UV absorption spectroscopy, fluorescence emission spectroscopy and viscosity. In addition, the cleavage reaction with pBR322 supercoiled plasmid DNA was investigated. The complex binds to DNA and also exhibits significant DNA cleavage activity.

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Acknowledgments

This research was supported by the National Natural Science Foundation of China to C. F. Bi (Nos. 21371161 and 21071134), the Specialized Research Fund for the Doctoral Program of Higher Education of China to Y. H. Fan (No. 20120132110015), the Natural Science Foundation of Shandong Province to X. Zhang (No. ZR2012BQ026), the Special Foundation for Young Teachers of Ocean University of China to X. Zhang (No. 201113025).

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Authors and Affiliations

  1. Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, 266100, Shandong, People’s Republic of China

    Xin Li, Cai-Feng Bi, Yu-Hua Fan, Xia Zhang, Xiao-Dan Wei & Xiang-Min Meng

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  1. Xin Li
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  2. Cai-Feng Bi
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  3. Yu-Hua Fan
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  4. Xia Zhang
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Correspondence to Cai-Feng Bi or Yu-Hua Fan.

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Li, X., Bi, CF., Fan, YH. et al. Synthesis, characterization, DNA binding and cleavage properties of a ternary copper(II) Schiff base complex. Transition Met Chem 39, 577–584 (2014). https://doi.org/10.1007/s11243-014-9836-7

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  • DOI: https://doi.org/10.1007/s11243-014-9836-7

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