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Synthesis, Crystal Structure and DNA Interaction of a Novel Three-Nuclear Cobalt(II) Complex with Schiff Base Derived from 4-Chloroanthranilic Acid and 2,4-Dihydroxybenzaldehyde

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Abstract

A novel transition metal coordination polymer [Co3(C14H8NO4Cl)4(CH3OH)4·4CH3OH]n with Schiff base (C14H8NO4Cl: 4-chloroanthranilic acid- 2,4-dihydroxybenzaldehyde) was synthesized using 4-chloroanthranilic acid, 2,4-dihydroxybenzaldehyde and cobalt(II) acetate as source, and its structure was characterized by IR spectroscopy, elemental analysis, 1H NMR and single crystal X-ray diffraction. X-ray crystallography shows that every cobalt atom is six-coordinated. Two cobalt atoms on the two sides are respective coordinated with two nitrogen atoms from –C=N–, two carboxylic oxygen atoms and two hydroxyl oxygen atoms in different ligands, while the cobalt atom in the middle links two ligands on the side through two carboxylic oxygen atoms and coordinates with four oxygen atoms of methanol, forming a three-nuclear Co(II) complex. The complex forms a two-dimensional layer structure through O–H···O intermolecular hydrogen bonds. The interaction of the Co(II) complex with calf-thymus DNA (CT-DNA) was investigated by UV absorption spectroscopy, fluorescence emission spectroscopy, viscosity and cyclic voltammetry. All measurements revealed that the Co(II) complex binds to DNA via a intercalative mode.

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Acknowledgments

This research was supported by the National Natural Science Foundation of China to C.F. Bi (No. 21371161 and No. 21071134), the Specialized Research Fund for the Doctoral Program of Higher Education of China to Y.H. Fan (No. 20120132110015), the Natural Science Foundation of Shandong Province to X. Zhang (No. ZR2012BQ026), the Special Foundation for Young Teachers of Ocean University of China to X. Zhang (No. 201113025).

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Authors and Affiliations

  1. Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Ocean University of China, Qingdao, 266100, Shandong, People’s Republic of China

    Xin Li, Cai-Feng Bi, Yu-Hua Fan, Xia Zhang, Nan Zhang & Xing-Chen Yan

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  1. Xin Li
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  2. Cai-Feng Bi
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  3. Yu-Hua Fan
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  4. Xia Zhang
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  5. Nan Zhang
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Correspondence to Cai-Feng Bi or Yu-Hua Fan.

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Li, X., Bi, CF., Fan, YH. et al. Synthesis, Crystal Structure and DNA Interaction of a Novel Three-Nuclear Cobalt(II) Complex with Schiff Base Derived from 4-Chloroanthranilic Acid and 2,4-Dihydroxybenzaldehyde. J Inorg Organomet Polym 24, 582–590 (2014). https://doi.org/10.1007/s10904-013-0010-z

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  • DOI: https://doi.org/10.1007/s10904-013-0010-z

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