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Syntheses, characterization, antimicrobial and genotoxic activities of new Schiff bases and their complexes

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Abstract

Two new Schiff base ligands (L1, L2) have been prepared from the reaction of 2,6-diacetylpyridine and 2-pyridinecarboxyaldehyde with 4-amino-2,3-dimethyl-1-phenyl-3-pyrozolin-5-on, and their Co(II), Cu(II), Ni(II), Mn(II), and Cr(III) metal complexes have also been prepared. The complexes are formed by coordination of N and O atoms of the ligands. Their structures were characterized by physico-chemical and spectroscopic methods. The analytical data shows that the metal to ligand ratio in the Schiff base complexes is 1:2. The Schiff base ligands and all complexes were evaluated for their in vitro antibacterial and antifungal activities by the disc diffusion method. In addition, the genotoxic properties of the ligands were studied.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science and Arts, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, 46050-9, Turkey

    E. İspir

  2. Department of Biology, Faculty of Science and Arts, Kahramanmaraş Sütçü İmam University, Kahramanmaras, 46050-9, Turkey

    S. Toroğlu & A. Kayraldız

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  1. E. İspir
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  2. S. Toroğlu
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  3. A. Kayraldız
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Correspondence to E. İspir.

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İspir, E., Toroğlu, S. & Kayraldız, A. Syntheses, characterization, antimicrobial and genotoxic activities of new Schiff bases and their complexes. Transition Met Chem 33, 953–960 (2008). https://doi.org/10.1007/s11243-008-9135-2

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  • DOI: https://doi.org/10.1007/s11243-008-9135-2

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