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Synthesis, Characterization, and Biological Activity of the Schiff Base and Its Ni(II), Cu(II), and Zn(II) Complexes Derived from 4-(Dimethylamino)benzaldehyde and S-Benzyldithiocarbazate

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Abstract

A Schiff base containing the nitrogen-sulfur donor chain [(CH3)2N-C6H4-CH=N-NH-C(S)-SCH2C6H5] was prepared by the condensation of 4-(dimethylamino)benzaldehyde and S-benzyldithiocarbazate and coordinated with Ni(II), Cu(II), and Zn(II). The Schiff base and its metal complexes were characterized by elemental analysis, IR, 1H and 13C NMR, electronic absorption spectroscopy and some of their physicochemical properties were determined. The Schiff bases behaved as a bidentate uninegative ligand in all the complexes, giving square-planar geometrical structures with Ni(II) and Cu(II) and a tetrahedral structure with Zn(II). The Schiff base and its complexes were screened for antibacterial activity. The biological activity testing results showed that the complexes were more potent antibiotics than the free ligand. The Cu(II) and Ni(II) complexes displayed high antibacterial potency and Zn(II) was moderately active against bacteria.

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Authors and Affiliations

  1. Department of Chemistry, Faculty of Science, Begum Rokeya University, Rangpur, 5400, Bangladesh

    M. A. Latif, Tania Tofaz, B. M. Chaki, H. M. Tariqul Islam & Md. Saddam Hossain

  2. Department of Chemistry, Faculty of Science, Rajshahi University, Rajshahi, 6500, Bangladesh

    Md. Kudrat-E-Zahan

Authors
  1. M. A. Latif
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  2. Tania Tofaz
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  3. B. M. Chaki
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  4. H. M. Tariqul Islam
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  5. Md. Saddam Hossain
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  6. Md. Kudrat-E-Zahan
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Corresponding author

Correspondence to Md. Kudrat-E-Zahan.

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Funding

This work was partially supported by the Ministry of Science and Technology, Bangladesh, through a research & development fund. Biological activities were evaluated at the Department of Pharmacy, University of Rajshahi.

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No conflict of interest was declared by the authors.

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Synthesis, Characterization, and Biological Activity of the Schiff Base and Its Ni(II), Cu(II), and Zn(II) Complexes Derived from 4-(Dimethylamino)benzaldehyde and S-Benzyldithiocarbazate

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Latif, M.A., Tofaz, T., Chaki, B.M. et al. Synthesis, Characterization, and Biological Activity of the Schiff Base and Its Ni(II), Cu(II), and Zn(II) Complexes Derived from 4-(Dimethylamino)benzaldehyde and S-Benzyldithiocarbazate. Russ J Gen Chem 89, 1197–1201 (2019). https://doi.org/10.1134/S107036321906015X

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  • DOI: https://doi.org/10.1134/S107036321906015X

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